Patents by Inventor Mark John Smyth

Mark John Smyth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS, PREPARATION AND USES THEREOF
    Publication number: 20130065897
    Abstract: The present invention provides novel compounds of the Formula I, pharmaceutical compositions comprising such compounds and methods for using such compounds as agents or drugs for inhibiting perforin activity and for treating a subject at risk of or susceptible to a disease or disorder, or having a disease or disorder associated with undesirable perforin activity.
    Type: Application
    Filed: December 22, 2010
    Publication date: March 14, 2013
    Applicant: PETER MACCALLUM CANCER INSTITUTE
    Inventors: Julie Ann Spicer, Kristiina Maria Huttunen, Dani Michelle Lyons, Joseph Albert Trapani, Mark John Smyth, William Alexander Denny
  • RECOMBINANT PERFORIN, EXPRESSION AND USES THEREOF
    Publication number: 20100261180
    Abstract: The present invention relates to retroviral vectors capable of driving the expression of perforin in a cell and a method of expressing recombinant perforin in a cell. The present invention also relates to recombinant perforin polypeptides and nucleic acid molecules derived therefrom and uses thereof. Also encompassed are screening assays employing such recombinant perforin molecules, compounds identified by the screening assays and uses thereof.
    Type: Application
    Filed: February 12, 2010
    Publication date: October 14, 2010
    Applicant: PETER MACCALLUM CANCER INSTITUTE
    Inventors: JOSEPH ALBERT TRAPANI, MARK JOHN SMYTH
  • Immunogobulin conjugates
    Patent number: 5798097
    Abstract: Immunoglobulin conjugates, comprising idarubicin (Ida) conjugated to a monoclonal antibody or fragment thereof comprising at least one of the antigen binding sites of the antigen, are useful for treating a human or other animal suffering from a cancer or for depleting a subset of T lymphocytes from a population of cells.
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: August 25, 1998
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Ian Farquhar Campbell McKenzie, Geoffrey Allan Pietersz, Mark John Smyth