Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, X1, X2, X3, X4, integer a and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: One embodiment provides a system, including: an inspection platform configured to move through underground infrastructure; an imaging device coupled to the inspection platform; the imaging device comprising a camera housing that arranges an array of four or more cameras in a predetermined configuration; the camera housing comprising a plurality of apertures, wherein each aperture houses a respective camera therein with a viewing axis offset about 30 degrees to about 120 degrees from a viewing axis of an adjacent camera within the array; and circuitry that operates the imaging device to capture a plurality of images using the four or more cameras; where the circuitry captures the plurality of images for a composite image of an interior region of the underground infrastructure, and where the region is larger than a single viewing field of any of the four or more cameras. Other embodiments are described and claimed.

Abstract: Users of personalized messaging systems can encounter message fatigue, thereby reducing the efficacy of a message on its intended recipient. Message fatigue can result in wasted computational resources and bandwidth as messages transmitted over a network to the user's client device are not acted upon at the client device. For applications involving desired user interactions and responses, personalized messaging can be a tool to achieve user engagement targets. The systems and methods presented herein may address several of the technical challenges with personalized messaging.

Abstract: Dynamically generating data tests includes: receiving test templates and metadata for a plurality of data objects and, on a trigger condition: based on at least the metadata and the test templates, determining a current set of templated data tests, wherein determining the current set of templated data tests comprises: determining at least one templated data test, from a prior set of templated data tests, to cease using; determining at least one templated data test to add to the current set of templated data tests; and determining, within the current set of templated data tests, at least one templated data tests to regenerate; generating the at least one templated data test to add to the current set of templated data tests; regenerating the least one templated data test to regenerate; and executing templated data tests, within the set of current templated data tests, on the plurality of data objects.

Abstract: An interactive toy, system, and method of controlling the same. The interactive toy includes a toy housing comprising therein a function device performing user-perceptible, controllable functions; a control circuit controlling the function device; a rechargeable power source providing operating power to the function device and the control circuit; and a charging circuit for contactless receipt of electrical energy and for charging the rechargeable power source when the interactive toy is positioned in a charging zone of a contactless charging device. The control circuit receives a primary signal indicative of an interaction stimulus; a secondary signal indicative of a position of the interactive toy with respect to the charging zone; and, responsive to the primary signal, controls the function device to perform a user-perceptible function selected based on the secondary signal. The interactive toy system includes an interactive toy and a contactless charging device defining one or more charging zones.

Abstract: One aspect provides a method, including: obtaining sensor data from a ground penetrating radar (GPR) unit; analyzing, using a processor, the sensor data to detect a first object and a second object, the second object being associated with the first object based on location; identifying, with the processor, an underground pipe feature based on the analyzing; associating a position of the underground pipe feature with a location in a pipe network; selecting a subset of the pipe network including a pipe segment associated with the position of the underground pipe feature; and providing the subset of the pipe network as displayable data to a display device. Other aspects are described and claimed.

Abstract: Apparatus and installation methods for sampling ports are disclosed. Sampling ports include a port housing and a lid assembly. The lid assembly is configured to sealably close against the port housing. Additionally, the lid assembly can be secured, such as with a lock, to the port housing. In one aspect, the port housing includes a sample mount arrangement configured to receive a sampling assembly. The sample mount arrangement defines a sampling channel and the port housing defines a sampling opening and a first securing mount. The lid assembly includes a latch arrangement and defines a second securing mount.

Abstract: A toy system comprising a plurality of toy construction elements, having detachably interconnecting coupling members for creating coherent spatial structures. The plurality of toy construction elements include: an energy source device comprising a housing and an energy transfer circuit therein; and energy distribution devices to provide respective external conductive loops extending outside the housing and defining a respective external energy transfer zone in a proximity of the respective external conductive loops. The energy source device is configured to be brought into operational connection with the energy distribution devices.

Abstract: An interactive toy, system, and method of controlling the same. The interactive toy includes a toy housing comprising therein a function device performing user-perceptible, controllable functions; a control circuit controlling the function device; a rechargeable power source providing operating power to the function device and the control circuit; and a charging circuit for contactless receipt of electrical energy and for charging the rechargeable power source when the interactive toy is positioned in a charging zone of a contactless charging device. The control circuit receives a primary signal indicative of an interaction stimulus; a secondary signal indicative of a position of the interactive toy with respect to the charging zone; and, responsive to the primary signal, controls the function device to perform a user-perceptible function selected based on the secondary signal. The interactive toy system includes an interactive toy and a contactless charging device defining one or more charging zones.

Abstract: Users of personalized messaging systems can encounter message fatigue, thereby reducing the efficacy of a message on its intended recipient. Message fatigue can result in wasted computational resources and bandwidth as messages transmitted over a network to the user's client device are not acted upon at the client device. For applications involving desired user interactions and responses, personalized messaging can be a tool to achieve user engagement targets. The systems and methods presented herein may address several of the technical challenges with personalized messaging.

Abstract: A modular toy system comprising a plurality of separate electronic toy modules, each electronic toy module comprising a function device operable to perform a user-perceptible function and a control circuit for controlling the function device; wherein at least a first electronic toy module of the plurality of electronic toy modules comprises a first control circuit, a first function device and a sensor system configured for contactless detection of respective coordinate values of at least two coordinates, each coordinate being indicative of a position or an orientation of at least a second electronic toy module of the plurality of electronic toy modules relative to the first electronic toy module; and wherein the first control circuit is configured to control operation of the first function device based on one or more of the detected coordinate values.

Abstract: Users of personalized messaging systems can encounter message fatigue, thereby reducing the efficacy of a message on its intended recipient. Message fatigue can result in wasted computational resources and bandwidth as messages transmitted over a network to the user's client device are not acted upon at the client device. For applications involving desired user interactions and responses, personalized messaging can be a tool to achieve user engagement targets. The systems and methods presented herein may address several of the technical challenges with personalized messaging.

Abstract: One aspect provides a method, including: obtaining sensor data from a ground penetrating radar (GPR) unit; analyzing, using a processor, the sensor data to detect a first object and a second object, the second object being associated with the first object based on location; identifying, with the processor, an underground pipe feature based on the analyzing; associating a position of the underground pipe feature with a location in a pipe network; selecting a subset of the pipe network including a pipe segment associated with the position of the underground pipe feature; and providing the subset of the pipe network as displayable data to a display device. Other aspects are described and claimed.

Abstract: An embodiment provides a method of controlling a pipe inspection robot, including: detecting, from a headset, brain activity of a user wearing the headset; binning the brain activity of the user into one of a plurality of different bins; the binning comprising accumulating brain activity values for a period of time to establish a brain activity value for the period of time; determining, using the brain activity value, if a threshold level of brain activity has accumulated over the period of time; after the threshold level has been accumulated, identifying a control action to be sent to the pipe inspection robot based on the brain activity value; and controlling the movement of the pipe inspection robot using a control signal associated with the control action. Other embodiments are described and claimed.

Abstract: One aspect provides a method, including: obtaining sensor data from an unmanned aerial vehicle (UAV); the sensor data comprising data obtained by one or more sensors of the UAV; analyzing, using a processor, the sensor data to detect underground water associated with a pipe; and identifying, with the processor, an underground feature based on the analyzing. Other aspects are described and claimed.

Abstract: One aspect provides operating a mobile pipe inspection platform to obtain two or more types of sensor data for the interior of a pipe; analyzing, using a processor, the two or more types of sensor data using a trained model, where the trained model is trained using a dataset including training sensor data of pipe interiors; the analyzing including performing: identifying, using a processor, a pipe feature location using a first type of the two or more types of sensor data; and classifying, using a processor, an identified pipe feature using a second type of the two or more types of sensor data; and thereafter producing, using a processor, an output including an indication of the classified pipe feature. Other aspects are described and claimed.

Abstract: Apparatus and installation methods for sampling ports are disclosed. Sampling ports include a port housing and a lid assembly. The lid assembly is configured to sealably close against the port housing. Additionally, the lid assembly can be secured, such as with a lock, to the port housing. In one aspect, the port housing includes a sample mount arrangement configured to receive a sampling assembly. The sample mount arrangement defines a sampling channel and the port housing defines a sampling opening and a first securing mount. The lid assembly includes a latch arrangement and defines a second securing mount.

Abstract: One aspect provides a method, including: displaying, at a display screen, an image of an interior of a pipe, the image being obtained using a pipe inspection robot; accessing, using a processor, calibration data associated with the image; receiving, via an input device, user input marking at least a portion of the image; determining, using a processor, quantitative pipe feature data for at least one feature of the pipe using the marking and the calibration data; and providing, based on the determining, data associated with the at least one feature. Other aspects are described and claimed.

Abstract: One aspect provides a method, including: operating a mobile pipe inspection platform to obtain sensor data for the interior of a pipe; analyzing, using a processor, the sensor data using a trained model, where the trained model is trained using a dataset including sensor data of pipe interiors and one or more of: metadata identifying pipe feature locations contained within the sensor data of the dataset and metadata classifying pipe features contained within the sensor data of the dataset; performing one or more of: identifying, using a processor, a pipe feature location within the sensor data; and classifying, using a processor, a pipe feature of the sensor data; and thereafter producing, using a processor, an output including one or more of an indication of the identifying and an indication of the classifying. Other aspects are described and claimed.

Abstract: Users of personalized messaging systems can encounter message fatigue, thereby reducing the efficacy of a message on its intended recipient. Message fatigue can result in wasted computational resources and bandwidth as messages transmitted over a network to the user's client device are not acted upon at the client device. For applications involving desired user interactions and responses, personalized messaging can be a tool to achieve user engagement targets. The systems and methods presented herein may address several of the technical challenges with personalized messaging.