Abstract: A medicament carrier (10) having a first and a second spaced apart screen (12, 14) each of which has surfaces (12B, 14B) defining a plurality of interstices (12A, 14A). The carrier (10) contains powdered agglomerated medicament particles (SM) loaded onto the first screen surface (12B) such that the interstices (12A) of the first screen (12) are at least partially open and free of the agglomerated medicament particles (SM). When an air stream is provided to the carrier to entrain the agglomerated powdered medicament particles (SM) and move them from the first screen (12) through the interstices (14A) of the second screen (14), the agglomerated powdered medicament particles (SM) are sheared by air flow gradients created by the first and second screens (12, 14) and by contact with the surface (14B) of the second screen (14) to create particles of respirable particle size range. The carrier (10) can be used in a dry powder inhalator device.

Abstract: An apparatus (100) adapted for applying to a carrier (C) a suspension (S) comprising a suspending agent and a powdered medicament. The apparatus (110) includes a reservoir (110), a junction container (120) adapted to contain a liquid, an outlet line (130) extending from the reservoir (110) and through the junction container (120) to a pump (P), a nozzle (160) connected to the pump (P) and a sonicator (150) operatively connected to the junction container (120). The reservoir (110) is adapted to maintain the agent and the medicament admixed in suspension. The nozzle (160) is formed from an inner cylinder (161) disposed within an outer cylinder (162), thereby defining a space (X) therebetween, and includes a purge line (165) fluidly connected with the outer cylinder (162) for providing a gas jet to the space (X).