Patents by Inventor Mark K. Doeven

Mark K. Doeven has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SINGLE UNIT CHROMATOGRAPHY ANTIBODY PURIFICATION
    Publication number: 20140187749
    Abstract: The present invention relates to a method for the purification of antibodies from a protein mixture produced in a bioreactor, at least comprising the steps of intermediate purification and polishing, wherein the intermediate and polishing step comprises in-line anion exchange chromatography (AEX) treatment and mixed mode chromatography (MiMo) treatment in flow through mode. The present invention further relates to a single operational unit comprising both an anion exchange chromatography part and a mixed mode chromatography part, which are serially connected, wherein the unit comprises an inlet at the upstream end of the anion exchange chromatography part and an outlet at the downstream end of the mixed mode chromatography part and wherein the unit also comprises an inlet between the anion exchange chromatography part and the mixed mode chromatography part.
    Type: Application
    Filed: June 8, 2012
    Publication date: July 3, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Maria Perlasca Islas, Diderik Reinder Kremer, Mark K. Doeven, Henderik E. Veenstra