Patents by Inventor Mark K. Mimee

Mark K. Mimee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene expression in Bacteroides
    Patent number: 11591604
    Abstract: Provided herein, in some aspects, are tools (e.g., methods, compositions and nucleic acids) for building genetic circuits in Bacteroides and Parabacteroides bacteria, as well as the bacteria containing the genetic circuits.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: February 28, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Mark K. Mimee, Christopher Voigt, Alex C. Tucker
  • TUNING MICROBIAL POPULATIONS WITH PROGRAMMABLE NUCLEASES
    Publication number: 20210071159
    Abstract: Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and/or destroying pathogenic microbial cells such as, for example, pathogenic bacterial cells. The methods include exposing microbial cells to a delivery vehicle with at least one nucleic acid encoding an engineered autonomously distributed circuit that contains a programmable nuclease targeted to one or multiple genes of interest.
    Type: Application
    Filed: July 23, 2020
    Publication date: March 11, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Robert James Citorik, Mark K. Mimee
  • INGESTIBLE SYSTEM TO MONITOR GASTROINTESTINAL HEALTH IN SITU
    Publication number: 20190313942
    Abstract: Disclosed herein are novel devices comprising small, ultra-low power microelectronic components. In some instances, the microelectronic components is combined with a biosensor component that enables in situ detection of biomolecules. Also disclosed herein are methods of detecting signal analytes and methods of monitoring the health of a patient using these novel devices.
    Type: Application
    Filed: April 17, 2018
    Publication date: October 17, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: TIMOTHY KUAN-TA LU, Mark K. Mimee, Phillip Nadeau, Anantha P. Chandrakasan
  • GENE EXPRESSION IN BACTEROIDES
    Publication number: 20180163216
    Abstract: Provided herein, in some aspects, are tools (e.g., methods, compositions and nucleic acids) for building genetic circuits in Bacteroides and Parabacteroides bacteria, as well as the bacteria containing the genetic circuits.
    Type: Application
    Filed: June 10, 2016
    Publication date: June 14, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Mark K. Mimee, Christopher Voigt, Alex C. Tucker
  • ENGINEERED BACTEROIDES OUTER MEMBRANE VESICLES
    Publication number: 20170145061
    Abstract: The present disclosure provides, in some aspects, versatile intestinal protein delivery systems deploying engineered human gut commensals of the Bacteroides species to secrete heterologous, therapeutic proteins via outer membrane vesicles (OMVs).
    Type: Application
    Filed: November 18, 2016
    Publication date: May 25, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: TIMOTHY KUAN-TA LU, Mark K. Mimee, Juliane Ripka
  • GENETICALLY ENGINEERED SENSORS FOR IN VIVO DETECTION OF BLEEDING
    Publication number: 20170058282
    Abstract: Provided herein are microorganisms engineered with heme-responsive transcription factors and genetic circuits. Also provided are methods for using engineered microorganisms to sense bleeding events and treat bleeding in vivo.
    Type: Application
    Filed: July 8, 2016
    Publication date: March 2, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Mark K. Mimee