Abstract: A delivery catheter for implanting a self-expanding implant such as a cardiovascular implant. An outer catheter shaft is formed as an implant capsule for encasing the implant during delivery. A flexible distal support element having a substantially truncated cone-shaped portion, which tapers in the proximal direction, is attached, directly proximally of the implant, in a fixed position to a first, inner catheter shaft, and/or a flexible proximal support element having a substantially truncated cone-shaped portion, which tapers in the proximal direction, is inserted at the proximal end of the implant capsule into the second, outer catheter shaft in a fixed position.

Abstract: A vehicle canopy includes a vehicle body defining a roof opening. A roof is connected to the vehicle body across the roof opening. A headliner is supported by at least one of the vehicle body and the roof. A frame is supported by the vehicle body. A fabric partition is engaged with the frame and extends across the roof opening between the headliner and the roof. The fabric partition may assist in preventing occupant test dummies and/or other objects from moving through the roof opening.

Abstract: A vehicle canopy includes a vehicle body defining a roof opening. A roof is connected to the vehicle body across the roof opening. A headliner is supported by at least one of the vehicle body and the roof. A frame is supported by the vehicle body. A fabric partition is engaged with the frame and extends across the roof opening between the headliner and the roof. The fabric partition may assist in preventing occupant test dummies and/or other objects from moving through the roof opening.

Abstract: A vehicle roof frame includes an adhering structure having an adhesive carrier and an expanding structural adhesive coupled to at least a portion of an outer surface of the adhesive carrier. The expanding structural adhesive includes an installation state and a structural state, and the structural state has a larger volume than the installation state. The vehicle roof frame also includes a plurality of vehicle frame members that cooperate to form a frame joint and a joint cavity defined within the frame joint. The adhering structure is disposed within the joint cavity and the adhesive carrier and the expanding structural adhesive in the structural state substantially occupies the joint cavity and fixably couples the plurality of framing members such that the frame joint is free of supplemental mechanical connections proximate the joint cavity.

Abstract: Provided herein are methods for increasing insulin secretion from beta cells. Also provide herein are methods comprising administering to a subject in need of increased insulin secretion a composition comprising a compound that directly or indirectly activates adenylate cyclase and an E prostanoid 3 (EP3) receptor antagonist that attenuates G alpha-i-subfamily (GSIS)-mediated adenylate cyclase inhibition.

Abstract: The subject disclosure is directed towards detecting malware or possible malware in an input file by allowing the input file to be opened, and by monitoring for one or more behaviors corresponding to the open file that likely indicate malware. Only certain executable files and/or file types opened thereby may be monitored, with various collected event data used for antimalware purposes when improper behavior is observed. Example behaviors include writing of a file to storage, generation of network traffic, injection of a process, running of script, and/or writing system registry data. Telemetry data and/or a sample of the file may be sent to an antimalware service, and malware remediation may be performed. Data (e.g., the collected events) may be distributed to other nodes for use in antimalware detection, e.g., to block execution of a similar file.

Abstract: Provided herein are methods for increasing insulin secretion from beta cells. Also provide herein are methods comprising administering to a subject in need of increased insulin secretion a composition comprising a compound that directly or indirectly activates adenylate cyclase and an E prostanoid 3 (EP3) receptor antagonist that attenuates G alpha-i-subfamily (GSIS)-mediated adenylate cyclase inhibition.

Abstract: Methods of processing an air-quenchable aluminum alloy component are provided. The method may include solution heat treating the component, air-quenching the component, and artificially aging the component to a yield strength of at least 200 MPa. The air-quenching may include cooling at a rate of 6° C./s to 25° C./s. The solution heat treatment may include heat treating the component at a temperature of 520° C. to 540° C. and the artificial aging step may include heat treating the component at 235° C. to 255° C. for 0.5 to 2 hours. The disclosed methods may produce a high strength (e.g., over 200 MPa) and high bendability (e.g., r/t ratio up to 0.3) component that does not significantly distort during the quenching process. The disclosed methods may be used to produce structural components having complex shapes, such as multiple, non-coplanar mating surface, while staying within predetermined tolerances.

Abstract: A vehicle having a roof panel connectedly extending inwardly from a body structure and a tether connectedly extending between the roof panel and body structure. The vehicle may be a pickup truck having a side body structure with an aluminum alloy internal panel and roof panel connected together to make up a portion of a passenger compartment of a cab. The tether assembly may have a mounting component adhesively connected to the roof panel and a tether rope connected to the mounting component and to the internal panel. The mounting component of the tether assembly may be taped to the roof panel. The mounting component may have a heat curing adhesive. The connector of the tether assembly may be fastened to the side body structure using a threaded fastener. The heat curing adhesive may be activated with an oven to secure the mounting component to the roof panel.

Abstract: One of more cross members of a pickup bed structure include a hole in a flange in a location that is advantageous for installation of aftermarket accessories. The hole does not extend through the floorpan itself. When customers install aftermarket accessories that require holes through the floorpan, the customers are encouraged to align the new holes with the holes in the cross members. Consequently, loads applied by the aftermarket accessories are efficiently transferred to the frame rails.

Abstract: A vehicle having a roof panel connectedly extending inwardly from a body structure and a tether connectedly extending between the roof panel and body structure. The vehicle may be a pickup truck having a side body structure with an aluminium alloy internal panel and roof panel connected together to make up a portion of a passenger compartment of a cab. The tether assembly may have a mounting component adhesively connected to the roof panel and a tether rope connected to the mounting component and to the internal panel. The mounting component of the tether assembly may be taped to the roof panel. The mounting component may have a heat curing adhesive. The connector of the tether assembly may be fastened to the side body structure using a threaded fastener. The heat curing adhesive may be activated with an oven to secure the mounting component to the roof panel.

Abstract: A vehicle canopy includes a vehicle body defining a roof opening. A roof is connected to the vehicle body across the roof opening. A headliner is supported by at least one of the vehicle body and the roof. A frame is supported by the vehicle body. A fabric partition is engaged with the frame and extends across the roof opening between the headliner and the roof. The fabric partition may assist in preventing occupant test dummies and/or other objects from moving through the roof opening.

Abstract: One of more cross members of a pickup bed structure include a hole in a flange in a location that is advantageous for installation of aftermarket accessories. The hole does not extend through the floorpan itself. When customers install aftermarket accessories that require holes through the floorpan, the customers are encouraged to align the new holes with the holes in the cross members. Consequently, loads applied by the aftermarket accessories are efficiently transferred to the frame rails.

Abstract: A vehicle roof frame includes an adhering structure having an adhesive carrier and an expanding structural adhesive coupled to at least a portion of an outer surface of the adhesive carrier. The expanding structural adhesive includes an installation state and a structural state, and the structural state has a larger volume than the installation state. The vehicle roof frame also includes a plurality of vehicle frame members that cooperate to form a frame joint and a joint cavity defined within the frame joint. The adhering structure is disposed within the joint cavity and the adhesive carrier and the expanding structural adhesive in the structural state substantially occupies the joint cavity and fixably couples the plurality of framing members such that the frame joint is free of supplemental mechanical connections proximate the joint cavity.

Abstract: A vehicle roof frame includes an adhering structure having an adhesive carrier and an expanding structural adhesive coupled to at least a portion of an outer surface of the adhesive carrier. The expanding structural adhesive includes an installation state and a structural state, and the structural state has a larger volume than the installation state. The vehicle roof frame also includes a plurality of vehicle frame members that cooperate to form a frame joint and a joint cavity defined within the frame joint. The adhering structure is disposed within the joint cavity and the adhesive carrier and the expanding structural adhesive in the structural state substantially occupies the joint cavity and fixably couples the plurality of framing members such that the frame joint is free of supplemental mechanical connections proximate the joint cavity.

Abstract: A vehicle front end structure including a fender support rail that includes a plurality of slots defined by an outer wall of the rail that facilitates bending the rail in a transverse vehicle direction. A plurality of circular holes may be provided that are defined in the rail adjacent a bend in the rail to facilitate fracturing the rail in a collision event. A bracket is attached to the rail adjacent the circular holes to inhibit the rail in that area from bending in an outboard direction.

Abstract: A vehicle roof frame includes an adhering structure having an adhesive carrier and an expanding structural adhesive coupled to at least a portion of an outer surface of the adhesive carrier. The expanding structural adhesive includes an installation state and a structural state, and the structural state has a larger volume than the installation state. The vehicle roof frame also includes a plurality of vehicle frame members that cooperate to form a frame joint and a joint cavity defined within the frame joint. The adhering structure is disposed within the joint cavity and the adhesive carrier and the expanding structural adhesive in the structural state substantially occupies the joint cavity and fixably couples the plurality of framing members such that the frame joint is free of supplemental mechanical connections proximate the joint cavity.

Abstract: A vehicle front end structure including a fender support rail that includes a plurality of slots defined by an outer wall of the rail that facilitates bending the rail in a transverse vehicle direction. A plurality of circular holes may be provided that are defined in the rail adjacent a bend in the rail to facilitate fracturing the rail in a collision event. A bracket is attached to the rail adjacent the circular holes to inhibit the rail in that area from bending in an outboard direction.