Abstract: A water diverter device for includes a hitch receiver that is attachable to a rear end of a vehicle. An angled member is releasably matable to the hitch receiver thereby enabling the angled member to extend rearwardly from the rear end of the vehicle. The angled member extends over an open fire hydrant when the vehicle is parked on a roadway adjacent to a location of the open fire hydrant. A terminal member is matable to the angled member and a diverter plate is attached to the terminal member. The diverter plate is positioned over the open fire hydrant to divert water spraying upwardly from the open fire hydrant into a lateral flow. In this way the water spraying upwardly does not rain down upon a service worker.

Abstract: Disclosed herein are methods of determining a tumor fraction of a sample from a subject. The methods can include, for example, acquiring a value for a target variable associated with a subgenomic interval m the sample; determining, from the target variable, a certainty metric: accessing a determined relationship between a stored certainty metric and a stored tumor fraction; and determining, with reference to the certainty metric and the determined relationship, the tumor fraction of the sample. In some instances, the method can further include determining a tumor fraction of the sample using a determination of somatic allele frequency when the estimate of tumor fraction calculated from the certainty metric falls below a cut-off threshold.

Abstract: The present invention provides therapeutic, diagnostic, and prognostic methods for cancer. The invention provides methods of treating a cancer, methods of determining whether an individual having a cancer is likely to respond to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of predicting responsiveness of an individual having a cancer to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of selecting a therapy for an individual having a cancer, methods of providing a prognosis for an individual having a cancer, and methods of monitoring a response of an individual having a cancer, based on a blood tumor mutational burden (bTMB) score or a maximum somatic allele frequency (MSAF) from a sample (e.g., a whole blood sample, a plasma sample, a serum sample, or a combination thereof) from the individual.

Abstract: Methods for determining a variant frequency in a test sample from a subject, and methods for labeling sequencing reads as having or not having a variant are described herein. Exemplary methods include generating a reference match score and a variant match score by aligning sequencing reads to a corresponding variant sequence and a corresponding reference sequence, and labeling the sequencing read as having or not having the variant based on the determined match scores. Also described herein are methods monitoring disease progression and methods of treating a subject having a disease. Further described are devices and systems for implementing such methods.

Abstract: The present invention provides therapeutic, diagnostic, and prognostic methods for cancer. The invention provides methods of treating a cancer, methods of determining whether an individual having a cancer is likely to respond to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of predicting responsiveness of an individual having a cancer to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of selecting a therapy for an individual having a cancer, methods of providing a prognosis for an individual having a cancer, and methods of monitoring a response of an individual having a cancer, based on a blood tumor mutational burden (bTMB) score or a maximum somatic allele frequency (MSAF) from a sample (e.g., a whole blood sample, a plasma sample, a serum sample, or a combination thereof) from the individual.

Abstract: The present invention provides therapeutic, diagnostic, and prognostic methods for cancer. The invention provides methods of treating a cancer, methods of determining whether an individual having a cancer is likely to respond to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of predicting responsiveness of an individual having a cancer to a treatment including an immune checkpoint inhibitor (e.g., a PD-L1 axis binding antagonist), methods of selecting a therapy for an individual having a cancer, methods of providing a prognosis for an individual having a cancer, and methods of monitoring a response of an individual having a cancer, based on a blood tumor mutational burden (bTMB) score or a maximum somatic allele frequency (MSAF) from a sample (e.g., a whole blood sample, a plasma sample, a serum sample, or a combination thereof) from the individual.

Abstract: Thermoplastic compositions useful for sealing longitudinal joints of substrates, for example, roadways and pavement, are provided herein. Formulations including the composition and methods of using the thermoplastic composition to seal longitudinal joints are also disclosed.

Abstract: A selective catalytic reduction (SCR) system for treating exhaust gas from a diesel engine is provided, along with a method of assembling such a system. The system comprises a frame, a SCR catalyst contained within a SCR canister, and an ammonia oxidation catalyst contained within an ammonia oxidation canister. Each of the SCR and ammonia oxidation canisters is removably attached to the frame.

Abstract: Thermoplastic compositions useful for sealing longitudinal joints of substrates, for example, roadways and pavement, are provided herein. Formulations including the composition and methods of using the thermoplastic composition to seal longitudinal joints are also disclosed.

Abstract: The disclosed computer-implemented method for protecting geolocation information may include (i) receiving, by a computing device, a geolocation security policy that defines an area in which access to geolocation information by applications will be at least partially limited to protect the privacy of a user, (ii) detecting, by the computing device, a geolocation of the computing device, (iii) applying, by the computing device, the geolocation security policy to the detected geolocation to determine whether the detected geolocation matches the area in which access to geolocation information by the applications will be at least partially limited, and (iv) performing, by the computing device, a security action to protect the privacy of the user based on determining that the detected geolocation matches the area. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Thermoplastic compositions useful for sealing longitudinal joints of substrates, for example, roadways and pavement, are provided herein. Formulations including the composition and methods of using the thermoplastic composition to seal longitudinal joints are also disclosed.

Abstract: A method for implementing adaptive policy based computer security is described. In one embodiment, the method may include monitoring a behavior of a user on a computing device associated with the user, determining whether the user triggers one or more policy triggers associated with a broad policy or at least one sub-policy of the broad policy, or both, and upon determining the user triggers at least one policy trigger during the monitoring period, implementing a customized version of the broad policy on the computing device. In some cases, the method may include implementing the broad policy on the computing device upon determining the user does not trigger any of the one or more policy triggers. In other cases, the method may include triggering at least one of the policy triggers based at least in part on a requested action and determining whether the requested action includes a security threat.

Abstract: The disclosed computer-implemented method for protecting a cloud storage against suspected malware may include (1) receiving a backup of one or more encrypted files over a network, (2) determining that the one or more encrypted files match one or more criteria associated with suspected malware, and (3) performing a security action that protects a computing device against the suspected malware. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A vehicular exterior mirror assembly includes a turn signal unit disposed at a mirror casing of the exterior mirror assembly. The turn signal unit includes a housing portion, at least one light source and a lens. With the exterior mirror assembly disposed at a side of an equipped vehicle, light emitted by the at least one light source, when the at least one light source is electrically powered, passes through the lens in the direction of forward travel of the equipped vehicle. With the exterior mirror assembly disposed at the side of the equipped vehicle, the turn signal unit (i) responsive to a charge level signal indicative of a vehicle charge level of a power source of the equipped vehicle, emits light to indicate the vehicle charge level, and (ii) responsive to actuation of a turn signal indicator of the equipped vehicle, emits light to provide a turn signal indication.

Abstract: An exterior rearview mirror assembly for a vehicle includes a turn signal unit having a housing, a light source and a lens disposed in front of the light source and attached at the housing. The turn signal unit includes an aperture element disposed between the light source and the lens, and includes a film disposed between the lens and the housing so as to be in front of the light source. With the exterior rearview mirror assembly disposed at a side of the vehicle, light emitted by the light source, when powered, passes through the film and through an aperture of the aperture element and through the lens in the forward direction of travel of the equipped vehicle. The film includes structured sections such that light emitted by the light source, when powered, passes through the structured sections of the film and forms an illuminated logo.

Abstract: A vehicular exterior mirror assembly includes a turn signal unit disposed at a mirror casing of the exterior mirror assembly. The turn signal unit includes a housing portion, at least one light source and a lens. With the exterior mirror assembly disposed at a side of an equipped vehicle, light emitted by the at least one light source, when the at least one light source is electrically powered, passes through the lens in the direction of forward travel of the equipped vehicle. With the exterior mirror assembly disposed at the side of the equipped vehicle, the turn signal unit (i) responsive to a charge level signal indicative of a vehicle charge level of a power source of the equipped vehicle, emits light to indicate the vehicle charge level, and (ii) responsive to actuation of a turn signal indicator of the equipped vehicle, emits light to provide a turn signal indication.