Abstract: The present invention relates to the field of methods of manufacturing of surface enhanced Raman spectroscopy (SERS) tags. The manufacturing method according to the present invention is reproducible and versatile and enables the production in an expedient manner of high quantities of SERS tags characterized by a narrow size distribution and a high ratio of low-number aggregates. SERS tags manufactured by the inventive manufacturing method described herein provide increased ensemble SERS responses.

Abstract: This disclosure provides methods of using a checkpoint kinase 1 (Chk1) inhibitor in the treatment of cancer in a subject having at least an intermediate tumor mutational burden (TMB), or a genetic abnormality in one or more particular genes associated with replicative stress. Accordingly, methods of treating cancer in a subject having at least an intermediate tumor mutational burden (TMB-I) are provided. Also provided are methods of treating cancer in a subject having a genetic abnormality in one or more particular genes selected from cell cycle regulation genes, replication stress genes, oncogenic driver mutations and DNA damage response and repair network genes. Methods of selecting subjects for Chk1 inhibition therapy are provided. The methods can include administering to the subject an effective amount of a SRA737 compound, in some cases in combination with low dose gemcitabine.

Abstract: A three-dimensional printing kit can include a particulate build material including from about 80 wt % to about 100 wt % metal particles, a binder fluid including water and latex particles in an amount of from about 5 wt % to about 30 wt % based on a total weight of the binder fluid, and an amine-bearing phosphonic adhesion promoter included in the binder fluid in an amount of from about 0.05 wt % to about 3.5 wt % based on a total amount of the binder fluid, or a separate adhesion promoter fluid in an amount of from about 0.1 wt % to about 5 wt % based on a total amount of the adhesion promoter fluid.

Abstract: Herein disclosed are methods of treatment administering SRA737 as a monotherapy or in a combination therapy useful for treating patients with cancer.

Abstract: A vehicle seat having a seat back pivotably coupled to a seat base by a seat recliner mechanism such that the seat back can be pivoted in a forward and rearward direction relative the seat base. The seat includes a track assembly coupled to the vehicle and the seat, such that the seat can be moved in the forward and rearward directions relative to the vehicle interior. The seat further includes an actuator mechanism having a first actuator that includes a push button located on the seat and an actuator in electrical communication with the push button, A force transmitting device has one end connected to the actuator and a second end connected to the seat recliner mechanism, such that energizing the actuator actuates the force transmitting device to release the seat recliner mechanism and move the seat between a use and a tipped and forward position.

Abstract: A vehicle seat having a seat back pivotably coupled to a seat base by a seat recliner mechanism such that the seat back can be pivoted in a forward and rearward direction relative the seat base. The seat includes a track assembly coupled to the vehicle and the seat, such that the seat can be moved in the forward and rearward directions relative to the vehicle interior. The seat further includes an actuator mechanism having a first actuator that includes a push button located on the seat and an actuator in electrical communication with the push button, A force transmitting device has one end connected to the actuator and a second end connected to the seat recliner mechanism, such that energizing the actuator actuates the force transmitting device to release the seat recliner mechanism and move the seat between a use and a tipped and forward position.

Abstract: The invention is to processes for producing a nanoglass powder batches and to powder batches formed by such processes. In one embodiment, the process comprises the steps of providing a precursor medium comprising a first metal oxide precursor to a first metal oxide, a second metal oxide precursor to a second metal oxide, and a liquid vehicle; and flame spraying the precursor medium under conditions effective to form aggregated nanoglass particles comprising the first and second metal oxides, wherein the aggregated nanoglass particles have an average primary particle size of from 25 nm to 500 nm. The aggregated nanoglass particles preferably have an average aggregate particle size of from 50 nm to 1000 nm and may be amorphous or crystalline.

Abstract: A coherency manager provides coherent access to shared data by receiving a copy of updated database data from a host computer through RDMA, the copy including updates to a given database data; storing the copy of the updated database data as a valid copy of the given database data in local memory; invalidating local copies of the given database data on other host computers through RDMA; receiving acknowledgements from the other host computers through RDMA that the local copies of the given database data have been invalidated; and sending an acknowledgement of receipt of the copy of the updated database data to the host computer through RDMA. When the coherency manager receives a request for the valid copy of the given database data from a host computer through RDMA, it retrieves the valid copy of the given database data from the local memory and returns the valid copy through RDMA.

Abstract: The invention is to processes for producing a nanoglass powder batches and to powder batches formed by such processes. In one embodiment, the process comprises the steps of providing a precursor medium comprising a first metal oxide precursor to a first metal oxide, a second metal oxide precursor to a second metal oxide, and a liquid vehicle; and flame spraying the precursor medium under conditions effective to form aggregated nanoglass particles comprising the first and second metal oxides, wherein the aggregated nanoglass particles have an average primary particle size of from 25 nm to 500 nm. The aggregated nanoglass particles preferably have an average aggregate particle size of from 50 nm to 1000 nm and may be amorphous or crystalline.

Abstract: Processes for the production of metal nanoparticles. In one aspect, the invention is to a process comprising the steps of mixing a heated first solution comprising a base and/or a reducing agent (e.g., a non-polyol reducing agent), a polyol, and a polymer of vinyl pyrrolidone with a second solution comprising a metal precursor that is capable of being reduced to a metal by the polyol. In another aspect, the invention is to a process that includes the steps of heating a powder of a polymer of vinyl pyrrolidone; forming a first solution comprising the powder and a polyol; and mixing the first solution with a second solution comprising a metal precursor capable of being reduced to a metal by the polyol.

Abstract: Processes for controlling ink migration during the formation of printable electronic features. In a preferred aspect, the invention is to a process for forming at least a portion of an electronic feature. The process includes the steps of: (a) providing a first substrate having a first surface; (b) modifying the first surface to form a modified surface; and (c) applying an ink to at least a portion of the modified surface, wherein the modified surface interacts with the ink to inhibit lateral and/or longitudinal migration of the applied ink, and wherein the applied ink forms at least a portion of the electronic feature. In another aspect, the invention is to a process for encouraging electronic ink spreading with a surfactant.

Abstract: An apparatus and a method for manufacturing electrical and optical materials by ink-jet printing of electronic ink(s) onto a flexible substrate are provided. The apparatus includes a flexible substrate, a first roll and a second roll, a printing head for depositing a electronic ink onto the substrate according to a predetermined pattern, and a drying station for drying an amount of deposited electronic ink. Each roll is reversibly configured for feed or takeup of the substrate. When dry, the deposited electronic ink forms one of an electronic material, an optical material, a display, and a fuel cell electrode. The apparatus may also include a second printing head configured for depositing a second electronic ink onto the substrate after the first ink has dried. The apparatus may be configured to rewind the substrate prior to deposition of the second ink, or to reverse the feed/takeup direction of the rolls.

Abstract: A process for the production of metal nanoparticles. The process comprises a rapid mixing of a solution of at least about 0.1 mole of a metal compound that is capable of being reduced to a metal by a polyol with a heated solution of a polyol and a substance that is capable of being adsorbed on the nanoparticles.

Abstract: The present invention relates to oxidized modified pigments and dispersions as well as methods of preparing them. Also disclosed are aqueous inkjet ink compositions comprising oxidized modified pigments.

Abstract: A metal nanoparticle composition for the fabrication of conductive features. The metal nanoparticle composition advantageously has a low viscosity permitting deposition of the composition by direct-write tools. The metal nanoparticle composition advantageously also has a low conversion temperature, permitting its deposition and conversion to an electrical feature on polymeric substrates.

Abstract: An electrical conductor formed from one or more metallic inks. The electrical conductor comprises a network of interconnected metallic nodes. Each node comprises a metallic composition, e.g., one or more metals or alloys. The network defines a plurality of pores having an average pore volume of less than about 10,000,000 nm3. The electrical conductors advantageously have a high degree of conductivity, e.g., a resistivity of not greater than about 10× the resistivity of the (bulk) metallic composition, which forms the individual nodes.

Abstract: A process for the production of metal nanoparticles. Nanoparticles are formed by combining a metal compound with a solution that comprises a polyol and a substance that is capable of being adsorbed on the nanoparticles. The nanoparticles are precipitated by adding a nanoparticle-precipitating liquid in a sufficient amount to precipitate at least a substantial portion of the nanoparticles and of a protic solvent in a sufficient amount to improve the separation of the nanoparticles from the liquid phase.

Abstract: Processes for planarizing a substrate, for encapsulating a printed electronic feature and for forming a ramp feature. In various embodiments, the processes include the steps of: (a) applying a planarizing agent, an encapsulating agent or a ramping feature to a substrate or to an electronic feature disposed thereon, preferably through a direct write printing process, e.g., ink-jet printing, and (b) treating the applied agent under conditions effective to form a planarizing feature, an encapsulation layer or a ramping feature.

Abstract: Processes for controlling ink migration during the formation of printable electronic features. In a preferred aspect, the invention is to a process for forming at least a portion of an electronic feature. The process includes the steps of: (a) providing a first substrate having a first surface; (b) modifying the first surface to form a modified surface; and (c) applying an ink to at least a portion of the modified surface, wherein the modified surface interacts with the ink to inhibit lateral and/or longitudinal migration of the applied ink, and wherein the applied ink forms at least a portion of the electronic feature. In another aspect, the invention is to a process for encouraging electronic ink spreading with a surfactant.

Abstract: Processes for forming conductive features from one or more inks and conductive features formed from the processes. In one aspect, the process includes a step of applying a first ink comprising a metal precursor to at least a portion of a first substrate to form an at least partially coated substrate. In a second step, the first ink is contacted with a reducing agent, optionally derived from a second ink, under conditions effective to reduce the metal in the metal precursor to its elemental form.