Patents by Inventor Mark L. Collins

Mark L. Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reduction of nonspecific hybridization by using novel base-pairing schemes
    Patent number: 5681702
    Abstract: Methods are provided for substantially reducing background signals encountered in nucleic acid hybridization assays. The method is premised on the elimination or significant reduction of the phenomenon of nonspecific hybridization, so as to provide a detectable signal which is produced only in the presence the target polynucleotide of interest. In addition, a novel method for the chemical synthesis of isoguanosine or 2'-deoxy-isoguanosine is provided. The invention also has applications in antisense and aptamer therapeutics and drug discovery.
    Type: Grant
    Filed: August 30, 1994
    Date of Patent: October 28, 1997
    Assignee: Chiron Corporation
    Inventors: Mark L. Collins, Thomas Horn, Patrick J. Sheridan, Brian D. Warner, Michael S. Urdea
  • Detection of campylobacter
    Patent number: 5663049
    Abstract: The invention relates to methods of using nucleic acid probes capable of specifically hybridizing to rRNA of Campylobacter jejuni, C. coli and C. laridis and not to rRNA or rRNA genes of Pseudomonas aeuroginosa, E. coli or Salmonella typhimunium for the detection of Campylobacter in clinical, food and other samples.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: September 2, 1997
    Assignee: Amoco Corporation
    Inventors: Susan M. Barns, Ray A. McMillian, David J. Lane, Mark L. Collins, James E. Awell, Ayoub Rashtchian
  • Hybridization promotion reagents
    Patent number: 5589335
    Abstract: Novel reagents are provided along with methods for their use in nucleic acid hybridization assays for detecting target nucleic acids in samples. The most preferred reagent is a mixture of guanidinium thiocyanate and tetramethylammonium:Trifluoracetate and possesses many properties for facilitating hybridization between target nucleic acid and nucleic acid probes capable of binding thereto and surprisingly results in the phenomenon of superstoichiometric labeling.
    Type: Grant
    Filed: August 11, 1994
    Date of Patent: December 31, 1996
    Assignee: Amoco Corporation
    Inventors: Kevin R. Kearney, Mark L. Collins, John K. Eldredge, David V. Morrissey
  • Methods and compositions for preventing interference with affinity capture schemes
    Patent number: 5457025
    Abstract: Methods and kits are described that allow the efficient capture and detection of targets employing the dA-dT and related affinity pairs from samples potentially containing large amounts of poly(rA) and/or poly(dA).
    Type: Grant
    Filed: November 16, 1992
    Date of Patent: October 10, 1995
    Assignee: Amoco Corporation
    Inventors: Mark L. Collins, David Gillespie, David V. Morrissey
  • Detection of campylobacter with nucleic acid probes
    Patent number: 5447848
    Abstract: Nucleic acid probes capable of specifically hybridizing to rRNA of Campylobacter jejuni, C. coli and C. laridis and not to rRNA or rRNA genes of Pseudomonas aeuroginosa, E. coli or Salmonella typhimunium are described along with methods utilizing such probes for the detection of Campylobacter in clinical, food and other samples.
    Type: Grant
    Filed: July 7, 1988
    Date of Patent: September 5, 1995
    Assignee: AMOCO Corporation
    Inventors: Susan M. Barns, Ray A. McMillian, David J. Lane, Mark L. Collins, James E. Awell, Ayoub Rashtchian