Patents by Inventor Mark L. Lang

Mark L. Lang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Clostridium difficile immunogenic compositions and methods of use
    Patent number: 10933126
    Abstract: An immunogenic composition containing a Clostridium difficile (C. difficile) surface polysaccharide II (PSII) or an immunogenic portion thereof; and an ?-galactosylceramide (?-GC) or analog or derivative thereof, which is able to bind to a CD1d glycoprotein, optionally containing a C. difficile TcdB C-terminal domain (CTD), or an immunogenic portion thereof, and/or an adjuvant. A method of treating, ameliorating, or inhibiting a C. difficile infection or a C. difficile-associated diarrhea in a subject by administering the immunogenic composition, particularly in subjects at risk for a C. difficile infection. A method of protecting a subject's gut microflora by administering the immunogenic composition or a composition containing ?-GC and an alum adjuvant.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: March 2, 2021
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Mark L. Lang, Jimmy D. Ballard
  • CLOSTRIDIUM DIFFICILE IMMUNOGENIC COMPOSITIONS AND METHODS OF USE
    Publication number: 20190336593
    Abstract: An immunogenic composition containing a Clostridium difficile (C. difficile) surface polysaccharide II (PSII) or an immunogenic portion thereof; and an ?-galactosylceramide (?-GC) or analog or derivative thereof, which is able to bind to a CD1d glycoprotein, optionally containing a C. difficile TcdB C-terminal domain (CTD), or an immunogenic portion thereof, and/or an adjuvant. A method of treating, ameliorating, or inhibiting a C. difficile infection or a C. difficile-associated diarrhea in a subject by administering the immunogenic composition, particularly in subjects at risk for a C. difficile infection. A method of protecting a subject's gut microflora by administering the immunogenic composition or a composition containing ?-GC and an alum adjuvant.
    Type: Application
    Filed: May 2, 2019
    Publication date: November 7, 2019
    Inventors: Mark L. Lang, Jimmy D. Ballard