Patents by Inventor Mark L. Nelson

Mark L. Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190015402
    Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
    Type: Application
    Filed: July 23, 2018
    Publication date: January 17, 2019
    Applicant: AbbVie Inc.
    Inventors: Mary E. Bellizzi, David A. Betebenner, Jean-Christophe C. Califano, William A. Carroll, Daniel D. Caspi, David A. DeGoey, Pamela L. Donner, Charles A. Flentge, Yi Gao, Charles W. Hutchins, Douglas K. Hutchinson, Tammie K. Jinkerson, Warren M. Kati, Ryan G. Keddy, Allan C. Krueger, Wenke Li, Dachun Liu, Clarence J. Maring, Mark A. Matulenko, Christopher E. Motter, Lissa T. Nelson, Sachin V. Patel, John K. Pratt, John T. Randolph, Todd W. Rockway, Kathy Sarris, Michael D. Tufano, Seble H. Wagaw, Rolf Wagner, Kevin R. Woller
  • Publication number: 20190012926
    Abstract: A method for enhanced safety and/or training compliance in computer systems is described. In one embodiment, the method includes generating a user interface to enable configuration of an in-person event, selecting a location for the in-person event, selecting a range threshold for the selected location of the in-person event, and determining whether a first attendee attended or is attending the in-person event based at least in part on a location of the first attendee relative to the location of the in-person event.
    Type: Application
    Filed: July 5, 2018
    Publication date: January 10, 2019
    Applicant: TYFOOM, LLC
    Inventors: N. Ryan Moss, Amber Beckstrom, Mark L. Nelson
  • Publication number: 20190012630
    Abstract: A method for improving safety and/or training compliance computer systems is described. In one embodiment, the method includes generating a safety rating of an entity, generating a safety rating of a person associated with the entity, detecting a safety compliance action of the person, updating the safety rating of the person based at least in part on the detected safety compliance action, and updating the safety rating of the entity based at least in part on the updating of the safety rating of the person. In some cases, the entity includes a corporation, a partnership, a company, an organization, an institution, or any group of people, or any combination thereof.
    Type: Application
    Filed: July 5, 2018
    Publication date: January 10, 2019
    Applicant: TYFOOM, LLC
    Inventors: N. Ryan Moss, Amber Beckstrom, Mark L. Nelson
  • Publication number: 20190012619
    Abstract: A method for improving safety and/or training compliance computer systems is described. In one embodiment, the method includes analyzing a plurality of incidents in real time based at least in part on one or more incident criteria; identifying an incident trend among at least one of the one or more incident criteria analyzed; analyzing a training history of at least a first organization that is associated with the incident trend; analyzing a training history of a second organization; and using machine learning to predict a future occurrence of an incident associated with the incident trend based at least in part on the analysis of the training history of the second organization.
    Type: Application
    Filed: July 5, 2018
    Publication date: January 10, 2019
    Applicant: TYFOOM, LLC
    Inventors: N. Ryan Moss, Amber Beckstrom, Mark L. Nelson
  • Publication number: 20190001653
    Abstract: The method of making a laminate (100) includes stretching a thermoplastic layer (102) so that it plastically deforms, relaxing the plastically deformed thermoplastic layer (102) to reduce its tensile strain, and subsequently laminating the thermoplastic layer (102) to a substrate (104) to make the laminate (100). The stretching, relaxing, and laminating are completed in-line. The thermoplastic layer has a first surface and a second surface opposite the first surface, with the first surface of the thermoplastic layer bearing a plurality of male fastening elements. The second surface of the thermoplastic layer (100) is laminated to the substrate (104).
    Type: Application
    Filed: December 19, 2016
    Publication date: January 3, 2019
    Inventors: Thomas J. Gilbert, Neelakandan Chandrasekaran, Todd L. Nelson, Michael R. Gorman, Mark A. Peltier
  • Publication number: 20180016225
    Abstract: Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.
    Type: Application
    Filed: May 15, 2017
    Publication date: January 18, 2018
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • Publication number: 20170305840
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: December 9, 2016
    Publication date: October 26, 2017
    Inventors: Mark L. Nelson, Kwasi Ohemeng, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Mohamed Y. Ismail, Oak K. Kim, Jude Mathews, Rachid Mechiche
  • Patent number: 9562003
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: February 7, 2017
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • Publication number: 20160324880
    Abstract: The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: December 8, 2015
    Publication date: November 10, 2016
    Inventors: Mark L. Nelson, Kwasi Ohemeng
  • Patent number: 9365500
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: June 14, 2016
    Assignee: PARATEK PHARMACEUTICALS, INC.
    Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
  • Patent number: 9278911
    Abstract: The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: March 8, 2016
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Kwasi Ohemeng
  • Publication number: 20160039749
    Abstract: 11a,12-dehydrotetracycline compounds are described.
    Type: Application
    Filed: May 23, 2013
    Publication date: February 11, 2016
    Inventors: Joel Berniac, Mohamed Y. Ismail, Mark L. Nelson, Farzaneh Seyedi
  • Publication number: 20160031802
    Abstract: The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: July 8, 2013
    Publication date: February 4, 2016
    Inventors: Upul Bandarage, Jackson Chen, Mohamed Y. Ismail, Mark L. Nelson, Kwasi Ohemeng
  • Publication number: 20150321997
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Application
    Filed: July 2, 2015
    Publication date: November 12, 2015
    Applicant: PARATEK PHARMACEUTICALS, INC.
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • Publication number: 20150141381
    Abstract: Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.
    Type: Application
    Filed: May 22, 2014
    Publication date: May 21, 2015
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • Publication number: 20150105355
    Abstract: The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: February 10, 2014
    Publication date: April 16, 2015
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Kwasi Ohemeng
  • Publication number: 20150045329
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: May 19, 2014
    Publication date: February 12, 2015
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Kwasi Ohemeng, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Mohamed Y. Ismail, Oak K. Kim, Jude Mathews, Rachid Mechiche
  • Publication number: 20140343020
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Application
    Filed: March 7, 2014
    Publication date: November 20, 2014
    Applicant: PARATEK PHARMACEUTICALS, INC
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • Publication number: 20140309199
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 27, 2014
    Publication date: October 16, 2014
    Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
  • Patent number: 8862438
    Abstract: A method for improving the prediction of polymer properties and a system having improved polymer property prediction capabilities is provided. The method for improving the prediction of polymer properties comprises: (1) providing a polymer; (2) providing a prediction model; (3) utilizing said prediction model to define an average polymer property prediction value; (4) determining a feasible range; (5) measuring one or more properties of said polymer; (6) determining whether said one or measured polymer properties are within said feasible range: (7) validating said one or more measured polymer properties if said one or more measured polymer properties fall within the feasible range or invalidating said one or more measured polymer properties if said one or more measured polymer properties fall outside of the feasible range; (8) optionally updating said prediction model; (9) repeating said previous steps at least one or more times; and (10) thereby improving the prediction of polymer properties.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: October 14, 2014
    Assignee: Dow Global Technologies LLC
    Inventors: Jeffrey B. Drabish, John R. Parrish, Marcel Schaefer, Ivan J. Hartley, Paul K. Samples, Mark L. Nelson