Patents by Inventor Mark L. Nelson

Mark L. Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180258442
    Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
    Type: Application
    Filed: February 20, 2018
    Publication date: September 13, 2018
    Inventors: Mark Scott Abad, Thomas R. Adams, Julie A. Alvarez, Mahindra Anuradha, Alice Clara Augustine, Erin Bell, Kristen A. Bennett, Robert J. Bensen, Paolo Castiglioni, Richard Eric Cerny, Xianfeng Chen, Jaishree M. Chittoor-Vijayanath, Farah Deeba, Jill Dcikman, Molian Deng, Stephen Duff, Bradon J. Fabbri, Jason Fenner, Mary Fernandes, Karen Gabbert, Barry S. Goldman, Deborah J. Hawkins, Jacqueline E. Heard, Balasulojini Karunanandaa, Dangyang Ke, John R. Ledeaux, Garrett J. Lee, Savitha Madappa, Donald E. Nelson, Obed Patty, Badami S. Pratesh, Qungang Qi, Ramachandra Dhanalakshmi, G. Ramamohan, Thomas G. Ruff, Rick A. Sanders, Sangeetha Singh, Thomas J. Savage, Beth Savidge, Char Shobha, Rajani Monnanda Somaiah, Padmini Sudarshana, Sreekanta Suma, Jindong Sun, Rebecca L. Thompson-Mize, Dale L. Val, Srikanth Venkatachalayya, Tymagondlu V. Venkatesh, Kammaradi Vidya, Jingrui Wu, Zhidong Xie, Nanfei Xu, Wei Zheng, Rajani Monnanda Somaiah, Meghan Galligan Donnarummo
  • Publication number: 20180016225
    Abstract: Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.
    Type: Application
    Filed: May 15, 2017
    Publication date: January 18, 2018
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • Publication number: 20170305840
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: December 9, 2016
    Publication date: October 26, 2017
    Inventors: Mark L. Nelson, Kwasi Ohemeng, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Mohamed Y. Ismail, Oak K. Kim, Jude Mathews, Rachid Mechiche
  • Patent number: 9562003
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: February 7, 2017
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • Publication number: 20160324880
    Abstract: The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: December 8, 2015
    Publication date: November 10, 2016
    Inventors: Mark L. Nelson, Kwasi Ohemeng
  • Patent number: 9365500
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: June 14, 2016
    Assignee: PARATEK PHARMACEUTICALS, INC.
    Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
  • Patent number: 9278911
    Abstract: The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: March 8, 2016
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Kwasi Ohemeng
  • Publication number: 20160039749
    Abstract: 11a,12-dehydrotetracycline compounds are described.
    Type: Application
    Filed: May 23, 2013
    Publication date: February 11, 2016
    Inventors: Joel Berniac, Mohamed Y. Ismail, Mark L. Nelson, Farzaneh Seyedi
  • Publication number: 20160031802
    Abstract: The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: July 8, 2013
    Publication date: February 4, 2016
    Inventors: Upul Bandarage, Jackson Chen, Mohamed Y. Ismail, Mark L. Nelson, Kwasi Ohemeng
  • Publication number: 20150321997
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Application
    Filed: July 2, 2015
    Publication date: November 12, 2015
    Applicant: PARATEK PHARMACEUTICALS, INC.
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • Publication number: 20150141381
    Abstract: Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.
    Type: Application
    Filed: May 22, 2014
    Publication date: May 21, 2015
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • Publication number: 20150105355
    Abstract: The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: February 10, 2014
    Publication date: April 16, 2015
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Kwasi Ohemeng
  • Publication number: 20150045329
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: May 19, 2014
    Publication date: February 12, 2015
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Kwasi Ohemeng, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Mohamed Y. Ismail, Oak K. Kim, Jude Mathews, Rachid Mechiche
  • Publication number: 20140343020
    Abstract: A method for modulating RNA with tetracycline compounds is described.
    Type: Application
    Filed: March 7, 2014
    Publication date: November 20, 2014
    Applicant: PARATEK PHARMACEUTICALS, INC
    Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
  • Publication number: 20140309199
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 27, 2014
    Publication date: October 16, 2014
    Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
  • Patent number: 8862438
    Abstract: A method for improving the prediction of polymer properties and a system having improved polymer property prediction capabilities is provided. The method for improving the prediction of polymer properties comprises: (1) providing a polymer; (2) providing a prediction model; (3) utilizing said prediction model to define an average polymer property prediction value; (4) determining a feasible range; (5) measuring one or more properties of said polymer; (6) determining whether said one or measured polymer properties are within said feasible range: (7) validating said one or more measured polymer properties if said one or more measured polymer properties fall within the feasible range or invalidating said one or more measured polymer properties if said one or more measured polymer properties fall outside of the feasible range; (8) optionally updating said prediction model; (9) repeating said previous steps at least one or more times; and (10) thereby improving the prediction of polymer properties.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: October 14, 2014
    Assignee: Dow Global Technologies LLC
    Inventors: Jeffrey B. Drabish, John R. Parrish, Marcel Schaefer, Ivan J. Hartley, Paul K. Samples, Mark L. Nelson
  • Publication number: 20140155357
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 14, 2013
    Publication date: June 5, 2014
    Inventors: Paul Abato, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Mark Grier, Laura Honeyman, Mohamed Y. Ismail, Mark L. Nelson, Kwasi Ohemeng, Jingwen Pan
  • Patent number: 8642348
    Abstract: Provided are efficient, cost-effective and water tolerant methods (e.g., single-vial methods) for preparing fatty acid esters from organic matter, including: obtaining organic matter having at least one fat substituent, contacting the organic matter in a reaction mixture with a basic solution under conditions suitable to provide for hydrolytic release of monomeric fatty acids from the at least one fat substituent to provide a base-treated reaction mixture, and esterifying the monomeric fatty acids of the base-treated reaction mixture by acidification of the reaction mixture and treating in the presence of an organic alcohol to provide fatty acid esters. The methods optionally further include, prior to esterifying, neutralizing the base-treated reaction mixture to provide for neutralized fatty acids, separating the neutralized fatty acids from the neutralized reaction mixture, and dissolving the separated fatty acids in the esterification reaction mixture.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: February 4, 2014
    Assignee: Washington State University
    Inventors: James V. O'Fallon, Charles T. Gaskins, Jan R. Busboom, Mark L. Nelson, Brian J. Kraft
  • Publication number: 20140031275
    Abstract: Disclosed herein are methods and compositions for the eradication of bacterial infections. In particular, methods and compositions are disclosed for the eradication of persister and slow growing bacterial cell populations. In particular embodiments, the methods and compositions disclosed herein are useful for eradication of biofilms.
    Type: Application
    Filed: October 1, 2013
    Publication date: January 30, 2014
    Applicant: NORTHEASTERN UNIVERSITY
    Inventors: Kim LEWIS, Brian CONLON, Mark L. NELSON, Michael P. POLLASTRI, Thomas A. DAHL
  • Patent number: 8492365
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: July 23, 2013
    Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage