Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

Abstract: The present invention provides tools and techniques for distinguishing a file from any or all copies of the file that may exist. One method ascertains (204) the actual physical location of the file (512) and associates (214) that physical location with the file as the claimed physical location (516) of the file. The file's originality status may then be determined (104) by finding (304) the location claim, reading (306) from it the claimed physical location associated with the file, ascertaining (308) the actual physical location of the file, and comparing (310) the locations. If the claimed and actual locations are identical, then the file is the original file it claims to be. If there is disparity between the claimed physical location recited for or by the file and the actual physical location of the file, then it is not the original file it claims to be.

Abstract: The present invention provides tools and techniques for distinguishing a file from any or all copies of the file that may exist. One method ascertains (204) the actual physical location of the file (512) and associates (214) that physical location with the file as the claimed physical location (516) of the file. The file's originality status may then be determined (104) by finding (304) the location claim, reading (306) from it the claimed physical location associated with the file, ascertaining (308) the actual physical location of the file, and comparing (310) the locations. If the claimed and actual locations are identical, then the file is the original file it claims to be. If there is disparity between the claimed physical location recited for or by the file and the actual physical location of the file, then it is not the original file it claims to be.

Abstract: The present invention provides tools and techniques for distinguishing a file from any or all copies of the file that may exist. One method ascertains (204) the actual physical location of the file (512) and associates (214) that physical location with the file as the claimed physical location (516) of the file. The file's originality status may then be determined (104) by finding (304) the location claim, reading (306) from it the claimed physical location associated with the file, ascertaining (308) the actual physical location of the file, and comparing (310) the locations. If the claimed and actual locations are identical, then the file is the original file it claims to be. If there is disparity between the claimed physical location recited for or by the file and the actual physical location of the file, then it is not the original file it claims to be.

Abstract: The present invention provides tools and techniques for distinguishing a file from any or all copies of the file that may exist. One method ascertains (204) the actual physical location of the file (512) and associates (214) that physical location with the file as the claimed physical location (516) of the file. The file's originality status may then be determined (104) by finding (304) the location claim, reading (306) from it the claimed physical location associated with the file, ascertaining (308) the actual physical location of the file, and comparing (310) the locations. If the claimed and actual locations are identical, then the file is the original file it claims to be. If there is disparity between the claimed physical location recited for or by the file and the actual physical location of the file, then it is not the original file it claims to be.

Abstract: A method and system are provided for managing digital documents by using links to allow navigation between documents and to create associations based on bridges between various combinations of document elements and software. Each bridge includes at least one coupling. Each coupling includes a target token identifier and a supplementary token identifier which allow software users to navigate between target and supplementary documents or to invoke supplementary software routines. Linked elements, such as text or graphics tokens, can overlap partially or entirely. Embedded links are allowed, but are not required.

Abstract: This invention relates to a method and apparatus for communication between an operator or agent position and a switching system and databases. The position includes a display screen and keyboard. Data for controlling a plurality of displays for the screen is stored in the switching system. In response to an operator's logging into the system, the position is connected to a plurality of databases by switched virtual channels, carried over the data channel of an ISDN connection from the position to the switch, and via switched virtual channels to the databases. A special section of the screen is devoted to parameters which are automatically transferred from one display to another whenever a new display is requested. When an operator wishes to set up a call, the call will be set up in accordance with the latest version of the parameters, whether or not the operator requests a display of a call control screen.