Patents by Inventor Mark L. Saxton

Mark L. Saxton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating tumors with CD8.sup.+ -depleted or CD4.sup.+ T cell subpopulations
    Patent number: 5725855
    Abstract: The present invention provides a method for enhancing the immunotherapeutic activity, e.g., antitumor activity, of immune cells by depleting immune cells of a cell subset that down-regulates the immune response, such as either CD4.sup.+ or CD8.sup.+ lymphocytes. The remaining depleted immune cell population or the separated immune cell subsets then are cultured in the presence of an antibody to a lymphocyte surface receptor, preferably an anti-CD3 monoclonal antibody (MoAb), optionally in the presence of a relatively minor amount of interleukin-2 (IL-2). These stimulated cells then are optionally additionally cultured in the presence of IL-2 without an antibody to a lymphocyte surface receptor. The present invention also provides a method of treating a mammal having tumors or immunizing a mammal against tumors by administering the stimulated depleted immune cell population or a stimulated immune cell subset to a mammal, advantageously together with an immunosuppressant, and with liposomal IL-2.
    Type: Grant
    Filed: March 22, 1994
    Date of Patent: March 10, 1998
    Assignees: The United States of America as represented by the Department of Health and Human Services, Regents of the Univ. of Minnesota
    Inventors: Augusto Carlos Ochoa, Mark L. Saxton, Dan L. Longo