Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

Abstract: A crossbow includes two rotatable cam assemblies mounted on a rigid cam support structure, the rotation axes of which are fixed relative to and arranged at a forward end of a stock. Limbs are coupled to provide limb tips rearward from the cam support structure. The limbs couple to the cam assemblies via power cables arranged generally parallel to the stock. The cam assemblies provide travel distance multiplication to a bowstring relative to the travel distance of the limb tips.

Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

Abstract: A business method for a primary nonprofit entity (PNE) to raise capital to finance a money-making project that benefits humanity by publicly raising funds from investors without involving a “security” and hence without invoking the jurisdiction of federal or state securities regulators. In lieu of securities, investors purchase “hearts” from the PNE. Hearts entitle their owner to direct the distribution of a proportionate amount of grant funds paid by the PNE to secondary nonprofit entities (SNEs). When and if the PNE's project is financially successful, it pays investment returns as grants to the SNEs as directed by each heart holder, respectively, in proportion to his or her hearts.

Abstract: A crossbow includes two rotatable cam assemblies mounted on a rigid cam support structure, the rotation axes of which are fixed relative to and arranged at a forward end of a stock. Limbs are coupled to the stock at positions rearward from the front of the stock. The limbs couple to the cam assemblies via power cables arranged generally parallel to the stock. The cam assemblies provide travel distance multiplication to a bowstring relative to the travel distance of the limb tips.

Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

Abstract: A crossbow includes two rotatable cam assemblies mounted on a rigid cam support structure, the rotation axes of which are fixed relative to and arranged at a forward end of a stock. Limbs are coupled to the stock at positions rearward from the front of the stock. The limbs couple to the cam assemblies via power cables arranged generally parallel to the stock. The cam assemblies provide travel distance multiplication to a bowstring relative to the travel distance of the limb tips.

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

Abstract: Compounds useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

Abstract: An apparatus for peeling in the production of three-dimensional objects is provided. The apparatus, disposed underneath a transparent bottom separation layer of a tank of a stereolithography apparatus allowing light from a light source to pass through the tank to solidify the liquid photopolymer contained in the tank, includes a tilt plate, a pivot connector, and a tilt actuator to move the tilt plate to separate an underneath support for the transparent bottom separation layer from the transparent bottom separation layer to create a slack of the transparent bottom separation layer of the tank to ease the peeling process in producing 3D objects.

Abstract: Compounds useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

Abstract: A plant wall and module for growing plants is disclosed in which the plant wall and module provide for the controlled delivery of water and nutrients to plants located on the plant wall and module. The plant wall may include a matrix of modules, each module filled with an inert growing medium. The inert growing medium preferably includes openings in which plants are secured and from which plants can grow from the growing medium. An irrigation system delivers water and nutrients to each module and may be removed and replaced from the plant wall without removal of the irrigation system. In addition, a drainage channel, such as a rear drainage channel, is formed so that excess water may exit from the modules. Capillary breaks may also be provided within the growing medium of each module to aid in the distribution of water and nutrients throughout the growing medium.

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, R7, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

Abstract: Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4 and R5 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases and pain.

Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

Abstract: Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, R7, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.