Patents by Inventor Mark Leo

Mark Leo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120213779
    Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
    Type: Application
    Filed: May 3, 2012
    Publication date: August 23, 2012
    Applicant: Amgen Inc.
    Inventors: Edward John Belouski, Murielle Marie Ellison, Agnes Eva Hamburger, Randy Ira Hecht, Yue-Sheng Li, Mark Leo Michaels, Jeonghoon Sun, Jing Xu
  • Publication number: 20120179155
    Abstract: An apparatus and method for use in performing ablation of organs and other tissues includes a radio frequency generator which provides a radio frequency signal to ablation electrodes. The power level of the radio frequency signal is determined based on the subject area of ablation. The radio frequency signal is coupled with the ablation electrodes through a transformation circuit. The transformation circuit includes a high impedance transformation circuit and a low impedance transformation circuit. The high or low impedance transformation circuit is selected based on the impedance of the ablation electrodes in contact with the subject tissue. Vacuum level, impedance level, resistance level, and time are measured during ablation. If these parameters exceed determinable limits the ablation procedure is terminated.
    Type: Application
    Filed: March 19, 2012
    Publication date: July 12, 2012
    Applicant: Cytyc Corporation
    Inventors: Bruno Strul, Csaba Truckai, Russel Mahlon Sampson, Mark Leo Kane
  • Publication number: 20120178685
    Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 12, 2012
    Applicant: Amgen Inc.
    Inventors: EDWARD JOHN BELOUSKI, Murielle Marie Ellison, Agnes Eva Hamburger, Randy Ira Hecht, Yue-Sheng Li, Mark Leo Michaels, Jeonghoon Sun, Jing Xu
  • Publication number: 20120177646
    Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
    Type: Application
    Filed: March 21, 2012
    Publication date: July 12, 2012
    Applicant: Amgen Inc.
    Inventors: Edward John Belouski, Murielle Marie Ellison, Agnes Eva Hamburger, Randy Ira Hecht, Yue-Sheng Li, Mark Leo Michaels, Jeonghoon Sun, Jing Xu
  • Patent number: 8188040
    Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: May 29, 2012
    Assignee: Amgen Inc.
    Inventors: Edward John Belouski, Murielle Marie Ellison, Agnes Eva Hamburger, Randy Ira Hecht, Yue-Sheng Li, Mark Leo Michaels, Jeonghoon Sun, Jing Xu
  • Patent number: 8184563
    Abstract: Different types of position fixes may be used to determine the location of a mobile station in a wireless communication system. The position fixes include terrestrial, or network, based techniques, and non-network based techniques, such as satellite, based techniques. An apparatus and method are presented by which different position fixes may be selected, based on the performance of a particular position fix in a particular mobile remote unit.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: May 22, 2012
    Assignee: QUALCOMM Incorporated
    Inventors: Wyatt Thomas Riley, Mark Leo Moeglein, Zoltan F. Biacs
  • Publication number: 20120093815
    Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
    Type: Application
    Filed: December 16, 2011
    Publication date: April 19, 2012
    Applicant: Amgen Inc.
    Inventors: EDWARD JOHN BELOUSKI, MURIELLE MARIE ELLISON, AGNES EVA HAMBURGER, RANDY IRA HECHT, YUE-SHENG LI, MARK LEO MICHAELS, JEONGHOON SUN, JING XU
  • Publication number: 20120087920
    Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
    Type: Application
    Filed: December 15, 2011
    Publication date: April 12, 2012
    Applicant: Amgen Inc.
    Inventors: Edward John Belouski, Murielle Marie Ellison, Agnes Eva Hamburger, Randy Ira Hecht, Yue-Sheng Li, Mark Leo Michaels, Jeonghoon Sun, Jing Xu
  • Publication number: 20120052069
    Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
    Type: Application
    Filed: May 4, 2010
    Publication date: March 1, 2012
    Applicant: AMGEN INC
    Inventors: Edward John Belouski, Murielle Marie Ellison, Agnes Eva Hamburger, Randy Ira Hecht, Yue-Sheng Li, Mark Leo Michaels, Jeonghoon Sun, Jing Xu
  • Publication number: 20120003216
    Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
    Type: Application
    Filed: August 2, 2011
    Publication date: January 5, 2012
    Applicant: AMGEN INC.
    Inventors: EDWARD JOHN BELOUSKI, MURIELLE MARIE ELLISON, AGNES EVA HAMBURGER, RANDY IRA HECHT, YUE-SHENG LI, MARK LEO MICHAELS, JEONGHOON SUN, JING XU
  • Publication number: 20110312320
    Abstract: Mobile device positioning includes a mobile device receiving a prompt to discover its position. In response to this prompt, the mobile device searches for communication signals between the mobile device and one of the communication satellites of the hybrid terrestrial-satellite communication system. If such signals are found, the mobile device accesses a communication satellite almanac to retrieve a location associated with the coverage area of the satellite spot beam in which the mobile device is currently located. Using this coverage area location information, the mobile device may access a satellite positioning system to obtain more accurate position data.
    Type: Application
    Filed: June 15, 2011
    Publication date: December 22, 2011
    Applicant: QUALCOMM Incorporated
    Inventor: Mark Leo Moeglein
  • Publication number: 20110291885
    Abstract: An almanac data management system at a location remote from a cell phone (20) has an almanac memory (44) for containing at least a current version of almanac data (52). A mobile device information memory (48) contains an identification of a version of almanac data held by the cell phone (20). A downloading system (56) selectively downloads at least a subset of the current version of almanac data (52) to the cell phone (20) if the current version of almanac data (52) is later than the version of almanac data held by the cell phone (20).
    Type: Application
    Filed: May 28, 2010
    Publication date: December 1, 2011
    Applicant: QUALCOMM Incorporated
    Inventors: Grant Alexander Marshall, Mark Leo Moeglein
  • Publication number: 20110279324
    Abstract: Methods, apparatuses, and systems are provided for processing positioning signals to obtain navigation information by applying compressed sensing.
    Type: Application
    Filed: May 14, 2010
    Publication date: November 17, 2011
    Applicant: QUALCOMM Incorporated
    Inventors: Josephine A. Bolotski, Douglas Neal Rowitch, Mark Leo Moeglein
  • Patent number: 8034770
    Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: October 11, 2011
    Assignee: Amgen Inc.
    Inventors: Edward John Belouski, Murielle Marie Ellison, Agnes Eva Hamburger, Randy Ira Hecht, Yue-Sheng Li, Mark Leo Michaels, Jeonghoon Sun, Jing Xu
  • Publication number: 20110105149
    Abstract: Different types of position fixes may be used to determine the location of a mobile station in a wireless communication system. The position fixes include terrestrial, or network, based techniques, and non-network based techniques, such as satellite, based techniques. An apparatus and method are presented by which different position fixes may be selected, based on the performance of a particular position fix in a particular mobile remote unit.
    Type: Application
    Filed: December 15, 2010
    Publication date: May 5, 2011
    Applicant: QUALCOMM Incorporated
    Inventors: Wyatt Thomas Riley, Mark Leo Moeglein, Zoltan F. Blacs
  • Publication number: 20110065457
    Abstract: The subject matter disclosed herein relates to determining whether a reported position of a wireless transmitter is sufficiently accurate in accordance with an accuracy metric based at least in part on a calculated range between an estimated position of a mobile station and the reported position and also based at least in part on one or more measurements taken from one or more signals transmitted by the wireless transmitter.
    Type: Application
    Filed: September 15, 2009
    Publication date: March 17, 2011
    Applicant: QUALCOMM Incorporated
    Inventors: Mark Leo Moeglein, Douglas Neal Rowitch, Ashok Bhatia, Kin Fai Wong
  • Publication number: 20110059756
    Abstract: The subject matter disclosed herein relates to creation, maintenance, communication, and/or use of sparse network almanac information that may be located in a mobile station.
    Type: Application
    Filed: September 8, 2010
    Publication date: March 10, 2011
    Applicant: QUALCOMM Incorporated
    Inventors: Mark Leo Moeglein, Zoltan F. Biacs
  • Publication number: 20110004367
    Abstract: The technical disclosure herein describes an autonomous water-borne vehicle having a segmented non-planing hull with free flood fore and aft sections and a sealed center section. The disclosure also described such a vehicle having a fixed longitudinal thruster and a fixed lateral thruster for changing the heading of the vehicle. The disclosure also described such a vehicle having an autonomous mission system, an autonomous navigation system, and a web-based command and control system. The disclosure also describes such a vehicle having a submersible winch. The disclosure also describes such a vehicle wherein the sealed center section is of substantially rectangular cross section. The disclosure also describes such a vehicle having a wheeled battery tray.
    Type: Application
    Filed: September 10, 2010
    Publication date: January 6, 2011
    Inventors: Jimmy Dale Saunders, Timothy Daniel Raymund, Jason Christopher Splawn, Scott William White, Debbie Lee Campbell, Cynthia Gaye Huyser, Petre Rusu, Mark Leo Brucks
  • Publication number: 20100285131
    Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
    Type: Application
    Filed: May 4, 2010
    Publication date: November 11, 2010
    Applicant: AMGEN INC.
    Inventors: Edward John Belouski, Murielle Marie Ellison, Agnes Eva Hamburger, Randy Ira Hecht, Yue-Sheng Li, Mark Leo Michaels, Jeonghoon Sun, Jing Xu
  • Publication number: 20100217256
    Abstract: An apparatus and method for use in performing ablation of organs and other tissues includes a radio frequency generator which provides a radio frequency signal to ablation electrodes. The power level of the radio frequency signal is determined based on the subject area of ablation. The radio frequency signal is coupled with the ablation electrodes through a transformation circuit. The transformation circuit includes a high impedance transformation circuit and a low impedance transformation circuit. The high or low impedance transformation circuit is selected based on the impedance of the ablation electrodes in contact with the subject tissue. Vacuum level, impedance level, resistance level, and time are measured during ablation. If these parameters exceed determinable limits the ablation procedure is terminated.
    Type: Application
    Filed: May 7, 2010
    Publication date: August 26, 2010
    Inventors: Bruno Strul, Csaba Truckai, Russel Mahlon Sampson, Mark Leo Kane