Patents by Inventor Mark Lloyd Stahl

Mark Lloyd Stahl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for identifying agents that interact with beta-site APP cleaving enzyme (BACE)
    Patent number: 7630838
    Abstract: This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: December 8, 2009
    Assignee: American Home Products Corporation
    Inventors: Rajiv Chopra, Kristine Svenson, Bethany Annis Freeman, Tatos N. Akopian, Jonathan Bard, Mark Lloyd Stahl, William S. Somers
  • MAMMALIAN EXPRESSION SYSTEMS
    Publication number: 20090214513
    Abstract: The present invention features mammalian expression systems with improved production yields, and method of using these systems to produce desired proteins. In one embodiment, the expression systems of the present invention comprise genetically-engineered mammalian host cells cultured in a medium that contains an effective amount of heparin or heparin-like molecules. The presence of heparin or heparin-like molecules significantly increases protein production by the cultured cells. The present invention also features the use of constitutively-active components of FGFR-I-mediated signal transduction pathways to improve protein production by cultured mammalian cells. Co-expression of such a component with a protein of interest markedly increases the production yield of the protein of interest.
    Type: Application
    Filed: April 20, 2006
    Publication date: August 27, 2009
    Applicant: Wyeth
    Inventors: Xiaotian Zhong, Ronald William Kriz, Mark Lloyd Stahl
  • Crystals of an acyl carrier protein synthase/acyl carrier protein complex
    Patent number: 7135319
    Abstract: This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: November 14, 2006
    Assignee: Wyeth
    Inventors: Kevin Delos Parris, William Stuart Somers, Amy Szepui Tam, Laura Long Lin, Mark Lloyd Stahl
  • Methods for identifying an agent that interacts with an active site of acyl carrier protein synthase or acyl carrier protein synthase complex
    Patent number: 6957150
    Abstract: This invention is directed to Acyl Carrier Protein Synthase (ACPS) crystals and crystals of Acyl Carrier Protein Synthase-Coenzyme A (ACPS-CoA) complex, and to the use of these crystals to determine the three dimensional structure of ACPS. This invention is further directed to the use of rational drug design methods to identify agents that may interact with active sites of ACPS and ACPS-CoA complex, and to the testing of these agents to identify agents that may inhibit ACPS and/or ACPS-CoA complex activity.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: October 18, 2005
    Assignees: Wyeth, Millennium Pharmaceuticals, Inc.
    Inventors: Kevin Delos Parris, William Stuart Somers, Amy Szepui Tam, Laura Long Lin, Mark Lloyd Stahl
  • Methods for identifying agents that interact with an active site of acyl carrier protein synthase-acyl carrier protein complex
    Patent number: 6684162
    Abstract: This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: January 27, 2004
    Assignees: Wyeth, Millennium Pharmaceuticals, Inc.
    Inventors: Kevin Delos Parris, William Stuart Somers, Amy Szepui Tam, Laura Long Lin, Mark Lloyd Stahl, Robert Powers, Guang-Yi Xu
  • METHODS FOR IDENTIFYING AGENTS THAT INTERACT WITH AN ACTIVE SITE
    Publication number: 20030211588
    Abstract: This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.
    Type: Application
    Filed: January 25, 2001
    Publication date: November 13, 2003
    Inventors: Kevin Delos Parris, William Stuart Somers, Amy Szepui Tam, Laura Long Lin, Mark Lloyd Stahl, Robert Powers, Guang-Yi Xu
  • Crystal structure of acyl carrier protein synthase and acyl carrier protein synthase complex
    Publication number: 20020094562
    Abstract: This invention is directed to Acyl Carrier Protein Synthase (ACPS) crystals and crystals of Acyl Carrier Protein Synthase-Coenzyme A (ACPS-CoA) complex, and to the use of these crystals to determine the three dimensional structure of ACPS. This invention is further directed to the use of rational drug design methods to identify agents that may interact with active sites of ACPS and ACPS-CoA complex, and to the testing of these agents to identify agents that may inhibit ACPS and/or ACPS-CoA complex activity.
    Type: Application
    Filed: January 25, 2001
    Publication date: July 18, 2002
    Inventors: Kevin Delos Parris, William Stuart Somers, Amy Szepui Tam, Laura Long Lin, Mark Lloyd Stahl
  • Crystal structure of bace and uses thereof
    Publication number: 20020055459
    Abstract: This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease.
    Type: Application
    Filed: September 19, 2001
    Publication date: May 9, 2002
    Inventors: Rajiv Chopra, Kristine Svenson, Bethany Annis, Tatos N. Akopian, Jonathan Bard, Mark Lloyd Stahl, William S. Somers