Patents by Inventor Mark Lovell
Mark Lovell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11911078Abstract: Implants, instruments, and methods for performing surgical procedures on the spine, including one or more of creating an operative corridor to the spine, delivering implants to the spine, fusing one or more segments of the spine, and fixing one or more segments of the spine.Type: GrantFiled: March 5, 2021Date of Patent: February 27, 2024Assignee: Nuvasive, Inc.Inventors: Troy B. Woolley, Nathan Lovell, Michael Serra, Mark Peterson
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Patent number: 9968574Abstract: The present invention provides, among other things, therapeutic compositions and methods that can effectively treat, slow or prevent a neurological disease (e.g., a neurodegenerative disease, e.g., mild cognitive impairment (MCI) or Alzheimer's disease (AD)), in particular, based on therapeutically effective amount of nifedipine, oxidized or nitroso nifedipine derivatives, lactam (e.g., a compound of formula (Ic) or (Ic-i), e.g., NFD-L1), thyroxine (T4), triiodothyronine (T3) and combinations thereof.Type: GrantFiled: November 18, 2010Date of Patent: May 15, 2018Assignee: The University of Kentucky Research FoundationInventors: Mark Lovell, Bert Lynn
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Patent number: 9835621Abstract: Disclosed is a method of detecting a concentration of a biomarker in a human subject having or being at risk of developing Alzheimer's disease or Mild Cognitive Impairment (MCI). Also disclosed is a process for detecting a concentration of a biomarker in a human subject having or being at risk of developing Alzheimer's disease or Mild Cognitive Impairment (MCI) comprising (a) detecting a first concentration of lipocalin-PDS/TTR complex in a blood sample or urine sample from the subject, (b) determining a second concentration of PDS/TTR complex in a blood sample or urine sample from an unaffected individual, and (c) comparing the first and second concentrations, wherein a lower first concentration as compared to the second concentration is indicative of the subject having or being at risk of developing Alzheimer's disease.Type: GrantFiled: July 16, 2012Date of Patent: December 5, 2017Assignee: University of Kentucky Research FoundationInventors: Mark A. Lovell, Bert C. Lynn
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Patent number: 9482675Abstract: The presently-disclosed subject matter includes methods and devices for diagnosing, prognosing, and treating brain damage in a subject, including brain damage caused by stroke or a traumatic brain injury (TBI). The methods can comprise providing a sample obtained from the subject, exposing the sample to an antibody selective for a visinin-like protein, detecting the presence of a complex that includes the antibody and the visinin-like protein, and diagnosing and/or prognosing the subject as having brain damage if there is the presence of the complex. Embodied methods can also comprise administering a treatment for brain damage if the subject includes the presence of the visinin-like protein.Type: GrantFiled: July 31, 2014Date of Patent: November 1, 2016Assignee: University of Kentucky Research FoundationInventors: Mark A. Lovell, Bert C. Lynn, Melissa A. Bradley-Whitman
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Publication number: 20140302535Abstract: Disclosed is a method of detecting a concentration of a biomarker in a human subject having or being at risk of developing Alzheimer's disease or Mild Cognitive Impairment (MCI). Also disclosed is a process for detecting a concentration of a biomarker in a human subject having or being at risk of developing Alzheimer's disease or Mild Cognitive Impairment (MCI) comprising (a) detecting a first concentration of lipocalin-PDS/TTR complex in a blood sample or urine sample from the subject, (b) determining a second concentration of PDS/TTR complex in a blood sample or urine sample from an unaffected individual, and (c) comparing the first and second concentrations, wherein a lower first concentration as compared to the second concentration is indicative of the subject having or being at risk of developing Alzheimer's disease.Type: ApplicationFiled: July 16, 2012Publication date: October 9, 2014Inventors: Mark A. Lovell, Bert C. Lynn
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Publication number: 20110118299Abstract: The present invention provides, among other things, therapeutic compositions and methods that can effectively treat, slow or prevent a neurological disease (e.g., a neurodegenerative disease, e.g., mild cognitive impairment (MCI) or Alzheimer's disease (AD)), in particular, based on therapeutically effective amount of nifedipine, oxidized or nitroso nifedipine derivatives, lactam (e.g., a compound of formula (Ic) or (Ic-i), e.g., NFD-L1), thyroxine (T4), triiodothyronine (T3) and combinations thereof.Type: ApplicationFiled: November 18, 2010Publication date: May 19, 2011Applicant: The University of Kentucky Research FoundationInventors: Mark Lovell, Bert Lynn
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Publication number: 20110104724Abstract: A method for quantifying a neurodegenerative disorder in a patient that includes obtaining a fluid sample from the subject; measuring a protein biomarker complex in said fluid sample and correlating the measurement with mild cognitive impairment or Alzheimer's disease status.Type: ApplicationFiled: November 8, 2010Publication date: May 5, 2011Applicant: University of Kentucky Research FoundationInventors: Mark A. Lovell, Bert C. Lynn
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Patent number: 7851172Abstract: A method for quantifying a neurodegenerative disorder in a patient that includes obtaining a fluid sample from the subject; measuring a protein biomarker complex in said fluid sample and correlating the measurement with mild cognitive impairment or Alzheimer's disease status. The biomarkers include those that comprise at least one of a transthyretin protein and/or a prostaglandin-H2 D-isomerase protein, and at least one second, different protein selected from a transthyretin, prostaglandin-H2 D-isomerase, beta-2-microglobulin, cystatin C, superoxide dismutase [Cu—Zn], plasma retinol-binding protein, phosphatidylethanolamine-binding protein, carbonic anhydrase 2, prostaglandin-H2 D-isomerase, and/or serotransferrin protein.Type: GrantFiled: July 25, 2006Date of Patent: December 14, 2010Assignee: University of Kentucky Research FoundationInventors: Mark A. Lovell, Bert C. Lynn
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Publication number: 20100292281Abstract: The present invention provides, among other things, therapeutic compositions and methods that can effectively treat, slow or prevent mild cognitive impairment (MCI) or Alzheimer's disease (AD), in particular, based on therapeutically effective amount of nifedipine, oxidized or nitroso nifedipine derivatives, thyroxine (T4), triiodothyronine (T3) and combinations thereof.Type: ApplicationFiled: May 13, 2010Publication date: November 18, 2010Applicant: The University of Kentucky Research FoundationInventors: Mark Lovell, Bert Lynn
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Publication number: 20080026405Abstract: A method for quantifying a neurodegenerative disorder in a patient that includes obtaining a fluid sample from the subject; measuring a protein biomarker complex in said fluid sample and correlating the measurement with mild cognitive impairment or Alzheimer's disease status.Type: ApplicationFiled: July 25, 2006Publication date: January 31, 2008Inventors: Mark A Lovell, Bert C. Lynn
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Patent number: 6783149Abstract: The invention relates to a gas bag module of several components, which comprise a least a carrier element, a gas generator and a gas bag. At least one elastic element is provided and at least one of the components is mounted in the gas bag module so as to be neutralized with regard to vibration by means of the at least one elastic element consisting of silicone.Type: GrantFiled: March 28, 2002Date of Patent: August 31, 2004Assignee: TRW Automotive Safety Systems GmbH & Co. KGInventors: Mark Lovell, Thorsten Nottebaum
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Publication number: 20020140210Abstract: The invention relates to a gas bag module of several components, which comprise a least a carrier element, a gas generator and a gas bag. At least one elastic element is provided and at least one of the components is mounted in the gas bag module so as to be neutralized with regard to vibration by means of the at least one elastic element consisting of silicone.Type: ApplicationFiled: March 28, 2002Publication date: October 3, 2002Applicant: TRW Automotive Safety Systems GmbH & Co. KGInventors: Mark Lovell, Thorsten Nottebaum
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Patent number: 5515403Abstract: In a telecommunication system having multiple timing subsystems receiving and distributing redundant timing signals, there is provided a circuitry for aligning first and second redundant timing signals and switching therebetween. The circuitry includes a selecting and switching circuitry for receiving the first and second redundant timing signals and designating one of the redundant timing signals as ACTIVE and the other as INACTIVE, and providing the ACTIVE timing signal as an output timing reference signal. The selecting and switching circuitry further switching the ACTIVE and INACTIVE timing signal designation and output timing reference signal in response to detecting fault or a clock switching command. The ACTIVE timing signal is provided to a first delay path having a programmable delay value, which delays it and produces a first output timing signal. A second delay path receives the INACTIVE redundant timing signal and produces a second output timing signal.Type: GrantFiled: June 21, 1994Date of Patent: May 7, 1996Assignee: DSC Communications CorporationInventors: Keith A. Sloan, Mark A. Lovell