Abstract: Systems and methods are disclosed for manually and programmatically remediating websites to thereby facilitate website navigation by people with diverse abilities. For example, an administrator portal is provided for simplified, form-based creation and deployment of remediation code, and a machine learning system is utilized to create and suggest remediations based on past remediation history. Voice command systems and portable document format (PDF) remediation techniques are also provided for improving the accessibility of such websites.

Abstract: Cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. The cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.

Abstract: A wearable electronic device comprises a housing, a feedback device, a depth sensor, and a processing element. The feedback device is located in the housing and configured to generate a vibration. The depth sensor is configured to generate a signal indicative of a current depth of the housing. The processing element is in electronic communication with the feedback device and the depth sensor. The processing element is configured to determine the current depth based on the signal indicative of a current depth and control the feedback device to generate the vibration in a pattern indicative of a rate of change in depth based at least in part on the current depth.

Abstract: A method for functionalizing a hollow-fiber membrane for cell expansion of targeted cells (e.g., natural killer cells) includes contacting a biotinylating molecule to a surface of the hollow-fiber membrane including an extracellular matrix component, the biotinylating molecule binding to the extracellular matrix component and having an affinity for the targeted cells. The biotinylated molecule may be selected from the group consisting of: cytokine, epitope, ligand, monoclonal antibody, stains, aptamer, and combinations thereof. The extracellular matrix component may be selected from the group consisting of: fibronectin, vitronectin, fibrinogen, collagen, laminin, and combinations thereof.

Abstract: Nephrotoxicity of anti-tumor platinum coordination compounds (e.g., cisplatin) is reduced by administering a dithiocarbamate chelator (e.g., diethyldithiocarbamate) at least 12 hours before as well as immediately after the administration of the anti-tumor compound.