Abstract: In an embodiment, a novel DNA-interactive compound is formed by coupling an alkali metal ion binding moiety with a DNA interactive moiety. An alkali metal ion binding moiety is any group capable of binding alkali metal ions (e.g., lithium, sodium, potassium, etc.). The DNA-interactive moiety is a group of atoms or functionality capable of covalently modifying DNA, through, for example, alkylation, cleavage, metalation, hydrolysis, or crosslinking.

Abstract: The present invention provides a gas generating engine for driving a beneficial agent dispensing device. The engine comprising (a) a solid composition comprising an acidic compound or a basic compound, or a combination thereof, and (b) a means for maintaining substantially constant the surface area of the solid composition exposed to a reservoir fluid comprising water, or water and an acidic compound, or water and a basic compound, wherein in operation, the solid composition is exposed to the reservoir fluid which dissolves the solid composition and causes it to generate a gas, the gas being a driving fluid to dispense a beneficial agent. The present invention further provides a fluid driven dispensing device for delivering an agent into an environment of use, the device be driven by the gas generating engine.