Abstract: An air bearing assembly is provided that includes a bearing sleeve that has two slots side-by-side having rectangular profiles for engaging the ends of first and second bearing foils for supporting a shaft of a dual-stage compressor. The first rectangular-profile slot, which may be made using a broaching process, is designed to receive first ends of the first bearing foil and the second bearing foil. The second rectangular-profile slot, which may also be made using a broaching process, is designed to receive a second end of the second bearing foil. This dual-slot design replaces the complex “L” shaped single slot design of conventional bearing sleeves, allowing for high-volume, low-cost manufacturing of the bearing sleeves. The dual-slot design also provides for robust engagement of the bearing foils with the bearing sleeves, while allowing easy assembly and installation of the air bearing assemblies.

Abstract: An air bearing assembly is provided that includes a bearing sleeve that has two slots side-by-side having rectangular profiles for engaging the ends of first and second bearing foils for supporting a shaft of a dual-stage compressor. The first rectangular-profile slot, which may be made using a broaching process, is designed to receive first ends of the first bearing foil and the second bearing foil. The second rectangular-profile slot, which may also be made using a broaching process, is designed to receive a second end of the second bearing foil. This dual-slot design replaces the complex “L” shaped single slot design of conventional bearing sleeves, allowing for high-volume, low-cost manufacturing of the bearing sleeves. The dual-slot design also provides for robust engagement of the bearing foils with the bearing sleeves, while allowing easy assembly and installation of the air bearing assemblies.

Abstract: The present invention relates to methods and systems for de novo iterative synthesis, an automated iterative drug discovery method and system providing for rapid identification and synthesis of novel compounds.

Abstract: The present invention is an oro-fiberscopic biteblock. The biteblock is utilized during oral fiberscopic procedures. The biteblock includes a main structure having an orifice sized to accommodate entry of a fiberscope, such as an endoscope, through the orifice. The biteblock includes an extension extending inward from the main structure when positioned within the mouth of a patient. On each side of the orifice is a loop for handling and positioning the biteblock within the patient's mouth. The biteblock includes an exhalation tube running from the extension to a monitoring device which allows monitoring of the patient's expelled gases. In addition, an inhalation tube may be used to provide supplemental oxygen to the patient. The biteblock is positioned in the mouth of the patient with the mouth of the patient surrounding the extension. The tubes include openings which are located on the extension and lie in the interior of the mouth to provide monitoring of uncontaminated gasses expelled by the patient.

Abstract: A method of comparing two conformers in which any score is obtained by determining the field value for molecule A at the coordinates of molecule B's field point. Molecule B's field point does not have to be very close to molecule A's field point to get a good overlay score: it just needs to be in a region where molecule A's field is large. This overcomes a limitation of conventional pseudo-Coulombic scoring in which a low score is achieved when extrema of large extent overlap but have their minimum points widely separated. The method can be applied to molecular mechanics modelling using atom centred charges (ACCs) and extended electron distributions (XEDs) as well as to quantum mechanics models.

Abstract: A computer system comprising a database (100) having a plurality of records, is provided. Each record comprises a filed point representation representing field extrema for a conformation of a chemical structure. The database may include records for multiple conformations of the same chemical structure. Each record can have a searchable index of the filed point representation. In one embodiment the index is bit string. An indexing mechanism for generating an index, a searching mechanism for searching the database and a graphical user interface to enable a user to interface with the database (100) are also provided.