Abstract: This disclosure provides techniques for pooling and searching network security events reported by multiple sources. As information representing a security event is received from one source, it is searched against a central or distributed database representing events reported from multiple, diverse sources (e.g., different client networks). Either the search or correlated results can be filtered and/or routed according at least one characteristic associated with the networks, for example, to limit correlation to events reported by what are presumed to be similarly situated networks. The disclosed techniques facilitate faster identification of high-relevancy security event information, and thereby help facilitate faster threat identification and mitigation. Various techniques can be implemented as standalone software (e.g., for use by a private network) or for a central pooling and/or query service. This disclosure also provides different examples of actions that can be taken in response to search results.

Abstract: An improved seal disposed at an interface of a main body of an inner drilling riser tie-back connector (ITBC) and a subsea wellhead is provided. The seal comprises a main body portion formed of a pair of opposed inwardly projecting fingers having a saw-cut profile at their ends and an outwardly projecting lever arm disposed adjacent to and at an outward angle to one of the opposed inwardly projecting fingers. Under loading the outwardly projecting lever arm imparts a bending moment to the seal, which enhances the seal created between the ITBC and the subsea wellhead and reduces the torque required to disengage the internal tie-back connector.

Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: In one embodiment, a vertical ratcheting anti-rotation device includes a ratchet mechanism pivotally coupled at a proximal end to a first tubular member in a first recessed area located on a shoulder of the first tubular member. A distal end of the ratchet mechanism includes a first plurality of angled teeth and a spring allowing the ratchet mechanism to pivot in a vertical direction within the first recessed area. The anti-rotation device may also include a toothed insert mechanically coupled to a second tubular member in a second recessed area located on a shoulder of the second tubular member. The toothed insert may include a second plurality of angled teeth positioned to engage the first plurality of angled teeth of the ratchet mechanism. The spring is compressible during coupling of the tubular members to allow the ratchet mechanism to move vertically over the second plurality of angled teeth.

Abstract: This disclosure provides techniques for pooling and searching network security events reported by multiple sources. As information representing a security event is received from one source, it is searched against a central or distributed database representing events reported from multiple, diverse sources (e.g., different client networks). Either the search or correlated results can be filtered and/or routed according at least one characteristic associated with the networks, for example, to limit correlation to events reported by what are presumed to be similarly situated networks. The disclosed techniques facilitate faster identification of high-relevancy security event information, and thereby help facilitate faster threat identification and mitigation. Various techniques can be implemented as standalone software (e.g., for use by a private network) or for a central pooling and/or query service. This disclosure also provides different examples of actions that can be taken in response to search results.

Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: A high capacity universal connector for use in connecting tubular members and a method for sealing the tubular members is provided. First and second tubular members are provided which each have ends that are brought into face-to-face engagement by a connector. A metal sealing element seals against conical surfaces at the ends of the first and second tubular members and enables the entire surface of the end of one tubular member to be bought into engagement with the surface of the end of the other tubular member so as to improve the bending and compression capacity of the assembly comprising the tubular members and the metal sealing element. A metal sealing ring for use in this assembly is also provided, along with a gasket retention assembly.

Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.

Abstract: The present invention is directed to methods for reducing immunogenicity of a drug product, utilizing filling a container wherein the filled container has no headspace. The present invention is further directed to methods for stabilizing an aqueous drug substance solution by filling a container with the aqueous drug substance solution wherein the filled container has no headspace. The present invention is further directed to formulations of drug substances with reduced immunogenicity.

Abstract: The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.