Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.

Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

Abstract: A method for in-service RAM testing in computer systems and networks having a virtual memory. The method involves identifying a number n of physical memory units pi, i=1 . . . n, in the RAM and a number n−1 of virtual memory units vj, j=1 . . . n−1, in the virtual memory, performing a one-to-one mapping to map the physical memory units pi to virtual memory units vj such that a physical memory unit px is left unmapped, and then testing data in the unmapped physical memory unit px by destructive or non-destructive tests. After the test data from another physical memory unit py is copied to physical memory unit px and a one-to-one re-mapping of physical memory units pi to virtual memory units vj is performed such that physical memory unit py is left unmapped. The data in physical memory unit py is then tested and the steps of copying, one-to-one re-mapping and testing can be repeated until all physical memory units pi are tested.

Abstract: A system for managing signal power levels in an optical network. The optical network comprises a plurality of nodes having logic to receive and transmit optical signals over a plurality of network interconnections. The system includes a method wherein each of the nodes is provided configuration parameters, each of the nodes is configured based on the configuration parameters, power parameter information is exchanged between the nodes, at least some of the nodes are re-configured based on the power parameter information and the steps of exchanging power parameter information and re-configuring at least some of the nodes are repeated until the optical network is fully configured so that the optical signals have selected signal power levels.

Abstract: A method for in-service RAM testing in computer systems and networks having a virtual memory. The method involves identifying a number n of physical memory units pi, i=1 . . . n, in the RAM and a number n−1 of virtual memory units vj, j=1 . . . n−1, in the virtual memory, performing a one-to-one mapping to map the physical memory units pi to virtual memory units vj such that a physical memory unit px is left unmapped, and then testing data in the unmapped physical memory unit px by destructive or non-destructive tests. After the test data from another physical memory unit py is copied to physical memory unit px and a one-to-one re-mapping of physical memory units pi to virtual memory units vj is performed such that physical memory unit py is left unmapped. The data in physical memory unit py is then tested and the steps of copying, one-to-one re-mapping and testing can be repeated until all physical memory units pi are tested.

Abstract: A monitoring device for detecting adulteration of an article used in critical use applications such as a surgical glove where the gloves are worn by the surgeon and are exposed to the body fluids of a patient. The device includes the detection of a particular value of electrical condition, preferably resistance or impedance, as well as the first and second derivatives of electrical condition. These values are monitored in a substantially continuous manner and are smoothed and filtered to determine when a hole or thin spot in the glove occurs. In addition, the device includes an autoranging function which maintains the measured voltage in a prescribed range, thus allowing the device to operate at a higher level of accuracy for a greater period of time than a device without the feature. Also, the device warns the health care professional when the electrical properties of the gloves have degraded to a point where the device may no longer reliably detect holes in the gloves.