Abstract: An endpoint for trusted fabrication, the endpoint including at least one secure controller configured for connection to a wide area network; and at least one untrusted controller configured for local communication, wherein the endpoint is configured for connection to a fabricator and further configured to receive digitally-signed data specifying at least one item for manufacture; verify the digitally-signed data; and direct the fabricator to manufacture the at least one item after verifying the digitally signed data. A method for trusted on-demand manufacturing, the method including receiving, at an endpoint connected to a fabricator, digitally signed data describing at least one item for manufacture; verifying, at the endpoint, the digitally signed data; and manufacturing the at least one item using the digitally signed data after verifying the digitally signed data, wherein the endpoint comprises at least one secure controller and at least one untrusted controller.

Abstract: An endpoint for trusted fabrication, the endpoint including at least one secure controller configured for connection to a wide area network; and at least one untrusted controller configured for local communication, wherein the endpoint is configured for connection to a fabricator and further configured to receive digitally-signed data specifying at least one item for manufacture; verify the digitally-signed data; and direct the fabricator to manufacture the at least one item after verifying the digitally signed data. A method for trusted on-demand manufacturing, the method including receiving, at an endpoint connected to a fabricator, digitally signed data describing at least one item for manufacture; verifying, at the endpoint, the digitally signed data; and manufacturing the at least one item using the digitally signed data after verifying the digitally signed data, wherein the endpoint comprises at least one secure controller and at least one untrusted controller.

Abstract: An endpoint for trusted fabrication, the endpoint including at least one secure controller configured for connection to a wide area network; and at least one untrusted controller configured for local communication, wherein the endpoint is configured for connection to a fabricator and further configured to receive digitally-signed data specifying at least one item for manufacture; verify the digitally-signed data; and direct the fabricator to manufacture the at least one item after verifying the digitally signed data. A method for trusted on-demand manufacturing, the method including receiving, at an endpoint connected to a fabricator, digitally signed data describing at least one item for manufacture; verifying, at the endpoint, the digitally signed data; and manufacturing the at least one item using the digitally signed data after verifying the digitally signed data, wherein the endpoint comprises at least one secure controller and at least one untrusted controller.

Abstract: An endpoint for trusted fabrication, the endpoint including at least one secure controller configured for connection to a wide area network; and at least one untrusted controller configured for local communication, wherein the endpoint is configured for connection to a fabricator and further configured to receive digitally-signed data specifying at least one item for manufacture; verify the digitally-signed data; and direct the fabricator to manufacture the at least one item after verifying the digitally signed data. A method for trusted on-demand manufacturing, the method including receiving, at an endpoint connected to a fabricator, digitally signed data describing at least one item for manufacture; verifying, at the endpoint, the digitally signed data; and manufacturing the at least one item using the digitally signed data after verifying the digitally signed data, wherein the endpoint comprises at least one secure controller and at least one untrusted controller.

Abstract: An endpoint for trusted fabrication, the endpoint including at least one secure controller configured for connection to a wide area network; and at least one untrusted controller configured for local communication, wherein the endpoint is configured for connection to a fabricator and further configured to receive digitally-signed data specifying at least one item for manufacture; verify the digitally-signed data; and direct the fabricator to manufacture the at least one item after verifying the digitally signed data. A method for trusted on-demand manufacturing, the method including receiving, at an endpoint connected to a fabricator, digitally signed data describing at least one item for manufacture; verifying, at the endpoint, the digitally signed data; and manufacturing the at least one item using the digitally signed data after verifying the digitally signed data, wherein the endpoint comprises at least one secure controller and at least one untrusted controller.

Abstract: Human CDK9 genes are identified as modulators of the IGF pathway, and thus are therapeutic targets for disorders associated with defective IGF function. Methods for identifying modulators of IGF, comprising screening for agents that modulate the activity of CDK9 are provided.

Abstract: Human RAB genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of RAB are provided.

Abstract: An apparatus for installation of a transmission fluid pan drain provides upper and lower deformation plates attachable to opposed sides of the transmission fluid pan by a threaded stud. The upper and lower deformation plates are sized and shaped so that when torque is applied to nuts carried on the threaded stud the plates are forced together, thereby deforming the transmission fluid pan, causing a depression or dimple in the fluid pan. After removing the deformation plates and stud, a hollow bolt is attachable in a fluid-tight manner to the transmission fluid pan in a manner wherein an upper end is carried above the pan and a lower threaded end is carried below the pan. An end cap is attachable to the threaded lower end of the hollow bolt, allowing transmission fluid to be drained by removing the end cap.