Abstract: The invention concerns benzamide derivatives of Formula (I) wherein R1a, R1b, R1c, R2, R3, R4, W, m and n have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of histone deacetylase (HDAC).

Abstract: A process for preparing an optically active compound of formula (II) or a salt thereof where * indicates a stereogenic centre; and R1 and R7 are as defined in the specification, which process comprises the acid hydrolysis of an optically active compound of formula (IV) where R5 and R6 are as defined in the specification, recovering the resultant optically active compound of formula (II) as a salt, and thereafter if desired, converting the salt to a compound of formula (II). The process is suitable for the preparation of; for instance, intermediates for pharmaceutical compounds. Certain novel intermediates are also disclosed and claimed.

Abstract: A system and method are provided that use explicitly and implicitly derived models of user information needs and content and presentation preferences together with relevancy feedback to expand a user's original query to the most related terms in a corpus and/or to allow the user to provide interactive feedback to enhance the relevance of selected news stories and display profile of the selected news stories. By personalizing both the selection of stories and the form in which they are delivered, users are provided with tailored broadcast news.