Abstract: Methods for producing and identifying fragments of proteins, and more particularly to methods for generating and identifying soluble protein domains are disclosed based on a method for generating a library of nucleic acid fragments from nucleic acid encoding a desired polypeptide, and more especially a library of essentially, randomly sampled fragments of coding DNA sequence predominantly of defined size range and a method for selecting cloned gene fragments from the library that encode soluble protein domains.

Abstract: Methods for producing and identifying fragments of proteins, and more particularly to methods for generating and identifying soluble protein domains are disclosed based on a method for generating a library of nucleic acid fragments from nucleic acid encoding a desired polypeptide, and more especially a library of essentially, randomly sampled fragments of coding DNA sequence predominantly of defined size range and a method for selecting cloned gene fragments from the library that encode soluble protein domains.

Abstract: This invention relates to conveyor guides comprising conveyor guide rail units, such as those used on automated handling lines where containers of different sizes are processed. One or more guide rails are employed to the sides of the conveyor guide to ensure that articles follow a desired path. This invention provides an adjustable conveyor guide rail unit that comprises a guide member operable to be set in a plurality of discrete positions, thereby allowing the width of a channel through which an article may be conveyed to be varied. The guide rails are adjustable to accommodate containers of differing sizes.

Abstract: This invention relates to conveyor guides comprising conveyor guide rail units, such as those used on automated handling lines where containers of different sizes are processed. One or more guide rails are employed to the sides of the conveyor guide to ensure that articles follow a desired path. This invention provides an adjustable conveyor guide rail unit that comprises a guide member operable to be set in a plurality of discrete positions, thereby allowing the width of a channel through which an article may be conveyed to be varied. The guide rails are adjustable to accommodate containers of differing sizes.

Abstract: This invention relates to conveyor guides comprising conveyor guide rail units, such as those used on automated handling lines where containers of different sizes are processed. One or more guide rails are employed to the sides of the conveyor guide to ensure that articles follow a desired path. This invention provides an adjustable conveyor guide rail unit that comprises a guide member operable to be set in a plurality of discrete positions, thereby allowing the width and/or height of a channel through which an article may be conveyed to be varied. The guide rails are adjustable to accommodate containers of differing sizes.

Abstract: A method for preparing a soluble protein comprising urokinase-type plasminogen activator (uPA) or an active fragment thereof, or a variant of either of these which has uPA activity, which method comprises contacting said protein with a buffer at a pH of from 8.5-10.5, said buffer comprising a reducing agent and an oxidising agent which forms a redox pair, wherein the reducing agent is present in excess compared to the oxidising agent, and wherein the reducing agent is present in a concentration of at least 5 mM. Material obtainable in this way forms a further aspect of the invention. It has been refolded in a “native-like” form and is useful in studies such as N.M.R. analysis to detect ligands.

Abstract: Structural coordinates obtainable by subjecting a crystal comprising a dimethylarginine dimethylaminohydrolase (DDAH) or a fragment thereof or an argininc deliminase (DI) or a fragment thercof to X-ray diffraction measurements and deducing the structural coordinales from the diffraction measurements arc used to identify, screen, characteristic, design or modify a chemical entity. The chemical entities so generated may be used in methods of Therapy or to identify the presence or absence of a DDAH or DI substrate.

Abstract: Methods for producing and identifying fragments of proteins, and more particularly to methods for generating and identifying soluble protein domains are disclosed based on a method for generating a library of nucleic acid fragments from nucleic acid encoding a desired polypeptide, and more especially a library of essentially, randomly sampled fragments of coding DNA sequence predominantly of defined size range and a method for selecting cloned gene fragments from the library that encode soluble protein domains.