Abstract: This invention relates to acrystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-5-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h] [2,5,11]benzoxadiazacyclo-tetradecine-3-carbonitrile (lorlatinib) free base (Form 7). This invention also relates to pharmaceutical compositions comprising Form 7, and to methods of using Form 7 and such compositions in the treatment of abnormal cell growth, such as cancer, in a mammal.

Abstract: The present invention provides an adjustable star wheel provided with at least one interchangeable pocket for receiving a container to be conveyed. The star wheel comprises a larger pocket of fixed shape and size, moveable jaws defining a smaller pocket having a fixed shape and size, an actuator disc rotatable about the central axis, and a cam mechanism linking the jaws to the actuator disc to cause radial movement of the jaws. In an extended position, the jaws move the smaller pocket into coincidence with the larger pocket thereby configuring the star wheel to receive containers in the smaller pocket. In the retracted position, the jaws are clear of the larger pocket thereby configuring the star wheel to receive containers in the larger pocket.

Abstract: The present invention provides an adjustable star wheel provided with at least one interchangeable pocket for receiving a container to be conveyed. The star wheel comprises a larger pocket of fixed shape and size, moveable jaws defining a smaller pocket having a fixed shape and size, an actuator disc rotatable about the central axis, and a cam mechanism linking the jaws to the actuator disc to cause radial movement of the jaws. In an extended position, the jaws move the smaller pocket into coincidence with the larger pocket thereby configuring the star wheel to receive containers in the smaller pocket. In the retracted position, the jaws are clear of the larger pocket thereby configuring the star wheel to receive containers in the larger pocket.