Patents by Inventor Mark McAllister
Mark McAllister has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11020376Abstract: This invention relates to acrystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-5-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h] [2,5,11]benzoxadiazacyclo-tetradecine-3-carbonitrile (lorlatinib) free base (Form 7). This invention also relates to pharmaceutical compositions comprising Form 7, and to methods of using Form 7 and such compositions in the treatment of abnormal cell growth, such as cancer, in a mammal.Type: GrantFiled: August 8, 2019Date of Patent: June 1, 2021Assignee: Pfizer Inc.Inventors: Klimentina Dimitrova Pencheva, Melissa Jane Birch, Stephen Mark McAllister, Martin Gregory Rowland, Ian Leonard Smales
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Publication number: 20190365712Abstract: This invention relates to acrystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-5-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h] [2,5,11]benzoxadiazacyclo-tetradecine-3-carbonitrile (lorlatinib) free base (Form 7). This invention also relates to pharmaceutical compositions comprising Form 7, and to methods of using Form 7 and such compositions in the treatment of abnormal cell growth, such as cancer, in a mammal.Type: ApplicationFiled: August 8, 2019Publication date: December 5, 2019Applicant: Pfizer Inc.Inventors: Klimentina Dimitrova Pencheva, Melissa J. Birch, Mark McAllister, Martin Rowland, Ian Leonard Smales
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Patent number: 8673350Abstract: The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.Type: GrantFiled: July 21, 2004Date of Patent: March 18, 2014Assignee: Capsugel Belgium NVInventors: Stephen Mark McAllister, Ronald K. Raby, Jr., Adrian Brown
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Patent number: 8561783Abstract: The present invention provides an adjustable star wheel provided with at least one interchangeable pocket for receiving a container to be conveyed. The star wheel comprises a larger pocket of fixed shape and size, moveable jaws defining a smaller pocket having a fixed shape and size, an actuator disc rotatable about the central axis, and a cam mechanism linking the jaws to the actuator disc to cause radial movement of the jaws. In an extended position, the jaws move the smaller pocket into coincidence with the larger pocket thereby configuring the star wheel to receive containers in the smaller pocket. In the retracted position, the jaws are clear of the larger pocket thereby configuring the star wheel to receive containers in the larger pocket.Type: GrantFiled: September 24, 2008Date of Patent: October 22, 2013Assignee: Zepf Technologies UK LimitedInventors: Mark McAllister, Ian Spence
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Patent number: 8454992Abstract: Capsule shells for use in multi-part dosage forms have generally cylindrical shell members with a snap fit component on an interior surface adjacent an open end, for connection to a linker part of the dosage form. The shell member also has a plurality of spaced apart integrally formed thin (relative to circumferentially adjacent shell member portions) panels located adjacent a closed shell member end, for preferential dissolution and release of pharmaceutical compositions from the shell member interior. The ratio of the thickness of the panels to the thickness of the shell member ranges from about 0.2 to about 0.6. The panels can be integrally formed together with the shell member as reliefs or depressions on the inner surface of the shell member by injection molding, and panel thicknesses as thin as about 0.1 mm can be achieved.Type: GrantFiled: October 15, 2008Date of Patent: June 4, 2013Assignee: Capsugel Belgium NVInventor: Stephen Mark McAllister
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Patent number: 8367101Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.Type: GrantFiled: January 30, 2002Date of Patent: February 5, 2013Assignee: Capsugel Belgium NVInventors: Stephen Mark McAllister, Ronald K. Raby, Jr., Adrian Brown, Allan J. Clarke, Daniel N. Margetson, Wayne Matthews
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Patent number: 8361498Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.Type: GrantFiled: November 23, 2010Date of Patent: January 29, 2013Assignee: Capsugel Belgium NVInventors: Stephen Mark McAllister, Ronald K. Raby, Jr., Adrian Brown, Allan J. Clarke
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Patent number: 8293159Abstract: A method of manufacturing a linker of the type having an injection molded jacket radially confining a preformed tablet. The method includes grasping the tablet about the outer surface with a plurality of pincers and positioning the grasped tablet and the pincers with respect to a molding apparatus. The method also includes supporting the tablet via the pincers and injecting jacket material to cover the outer tablet surface and the pincers. The method further includes extracting the jacketed tablet from the molding apparatus and removing the pincers from the jacketed tablet. The method may also include supporting and longitudinally positioning the tablet within the mold via a plurality of additional pincers.Type: GrantFiled: October 15, 2008Date of Patent: October 23, 2012Assignee: Capsugel BelgiumInventor: Stephen Mark McAllister
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Publication number: 20120196940Abstract: The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.Type: ApplicationFiled: January 31, 2012Publication date: August 2, 2012Inventors: Adrian Brown, Wayne M. Matthews, Daniel M. Margetson, Stephen Mark McAllister, Ronald K. Raby
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Patent number: 8147871Abstract: The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.Type: GrantFiled: March 11, 2005Date of Patent: April 3, 2012Assignee: Capsugel Belgium BVBAInventors: Adrian Brown, Wayne M. Matthews, Daniel M. Margetson, Stephen Mark McAllister, Ronald K. Raby
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Publication number: 20110300212Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.Type: ApplicationFiled: July 25, 2011Publication date: December 8, 2011Inventors: Stephen Mark McAllister, Ronald K. Raby, JR., Adrian Brown, Allan J. Clarke, Daniel N. Margetson, Wayne Matthews
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Publication number: 20110123608Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.Type: ApplicationFiled: November 23, 2010Publication date: May 26, 2011Applicant: SmithKline Beecham LimitedInventors: Stephen Mark McAllister, Ronald K. Raby, JR., Adrian Brown, Allan J. Clarke
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Publication number: 20110117190Abstract: The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.Type: ApplicationFiled: November 7, 2008Publication date: May 19, 2011Inventors: Adrian Brown, Lee J. Gorringe, Stephen Mark McAllister, Wayne M. Matthews, Danielle Genevieve Rebecca Russell
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Patent number: 7883721Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.Type: GrantFiled: January 30, 2002Date of Patent: February 8, 2011Assignee: SmithKline Beecham LimitedInventors: Stephen Mark McAllister, Ronald K. Raby, Jr., Adrian Brown, Allan J. Clarke, Wayne Matthews, Daniel N. Margetson
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Patent number: 7842308Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.Type: GrantFiled: January 30, 2002Date of Patent: November 30, 2010Assignee: SmithKline Beecham LimitedInventors: Stephen Mark McAllister, Ronald K. Raby, Jr., Adrian Brown, Allan J. Clarke
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Publication number: 20100193331Abstract: The present invention provides an adjustable star wheel provided with at least one interchangeable pocket for receiving a container to be conveyed. The star wheel comprises a larger pocket of fixed shape and size, moveable jaws defining a smaller pocket having a fixed shape and size, an actuator disc rotatable about the central axis, and a cam mechanism linking the jaws to the actuator disc to cause radial movement of the jaws. In an extended position, the jaws move the smaller pocket into coincidence with the larger pocket thereby configuring the star wheel to receive containers in the smaller pocket. In the retracted position, the jaws are clear of the larger pocket thereby configuring the star wheel to receive containers in the larger pocket.Type: ApplicationFiled: September 24, 2008Publication date: August 5, 2010Inventors: Mark McAllister, Ian Spence
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Publication number: 20100074947Abstract: The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.Type: ApplicationFiled: June 12, 2009Publication date: March 25, 2010Inventors: Adrian Brown, Wayne M. Matthews, Daniel N. Margetson, Stephen Mark McAllister, Danielle Genevieve Rebecca Russell
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Publication number: 20090148514Abstract: A multipart capsule, e.g., a dosage form, is provided which includes a plurality of capsule portions, at least one of which contains a substance to be released into a gastro-intestinal environment and at least one link component interconnecting two adjacent capsule portions. At least one capsule portion is formed from a polymer that is a transitional polymer, for example, a polymer that changes shape, form, or structure within a gastro-intestinal environment, e.g., dispersible, dissolvable, disintegrable, fracturable, breachable, swellable, partially or completely soluble, or otherwise changeable when exposed to stomach pH and/or in intestine pH to thereby release the substance. The capsule portions are connected together in an assembled dosage form. The link component includes at least one aperture in flow communication with interiors of two adjacent capsule portions to control the release of the substance.Type: ApplicationFiled: October 15, 2008Publication date: June 11, 2009Inventors: Wayne M. Matthews, Stephen Mark McAllister
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Publication number: 20090148518Abstract: The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.Type: ApplicationFiled: November 7, 2008Publication date: June 11, 2009Inventors: Adrian Brown, Lee J. Gorringe, Stephen Mark McAllister, Wayne M. Matthews, Danielle G. R. Russell
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Patent number: D735135Type: GrantFiled: August 2, 2013Date of Patent: July 28, 2015Assignee: Caterpillar (NI) LimitedInventors: James Todd, Mark McAllister