Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Abstract: A robotic strong arm (RSA) for assisting in the transfer of a person from a first surface to a second surface, comprising: first and second members, wherein in each member comprises a prismatic joint having first and second ends and comprising inner and outer shells and a motor for powered linear movement of the outer shell with respect to the inner shell; a first powered joint interconnecting the second end of the first member with the first end of the second member, wherein the first powered joint provides movement of the second member with respect to the first member; wherein the first end of the first member is attached to a rotatable base and wherein the rotatable base is movably attached for powered movement along a component associated with, and extending around at least a portion of a periphery about, the first surface; and a computer controller for controlling movements of the outer shells, first powered joint, rotation of the rotatable base and movement of the rotatable base and RSA along the compon

Abstract: A robotic strong arm (RSA) for assisting in the transfer of a person from a first surface to a second surface, comprising: first and second members, wherein in each member comprises a prismatic joint having first and second ends and comprising inner and outer shells and a motor for powered linear movement of the outer shell with respect to the inner shell; a first powered joint interconnecting the second end of the first member with the first end of the second member, wherein the first powered joint provides movement of the second member with respect to the first member; wherein the first end of the first member is attached to a rotatable base and wherein the rotatable base is movably attached for powered movement along a component associated with, and extending around at least a portion of a periphery about, the first surface; and a computer controller for controlling movements of the outer shells, first powered joint, rotation of the rotatable base and movement of the rotatable base and RSA along the compon

Abstract: Caster alignment mechanism having a first component operably connected to a leg of a mobile device and a second component operably connected to a caster of the mobile device. The first and second components are positioned in parallel orientation to each other wherein alignment of the caster with the leg of the mobile device is achieved by the attractive characteristics of the first component with an upper magnet to the second component with a lower magnet. One embodiment of the caster alignment mechanism includes a fixed gap between the upper magnet and the lower magnet for an always engaged or “on” mode. The fixed gap can be adjusted to vary magnetic field strength depending on user specifications for ease of turning. Another embodiment of the caster alignment mechanism includes a switching mechanism to change modes between engaged or “on” mode and disengaged or “off” mode.

Abstract: Caster alignment mechanism having a first component operably connected to a leg of a mobile device and a second component operably connected to a caster of the mobile device. The first and second components are positioned in parallel orientation to each other wherein alignment. of the caster with the leg of the mobile device is achieved by the attractive characteristics of the first component with an upper magnet to the second component with a lower magnet. One embodiment of the caster alignment mechanism includes a fixed gap between the upper magnet and the lower magnet for an always engaged or “on” mode. The fixed gap can be adjusted to vary magnetic field strength depending on user specifications for ease of turning. Another embodiment of the caster alignment mechanism includes a switching mechanism to change modes between engaged or “on” mode and disengaged or “off” mode.

Abstract: An improved caster comprising a caster mount attachable to a frame of a mobile device, caster stem attached to the caster mount and operable to attach to a caster fork and wheel assembly, and a biasing means operable to restrict the rotation of the caster stem and thereby to prevent caster drift and flutter and to promote tracking of the mobile device. The biasing means can be in manner whereby the caster stem has at least one vertical notch defined therein and the biasing means comprises a spring plunger located in the caster mount. The spring plunger has an internal spring and a movable ball member attached to the spring and which faces the caster stem whereby the ball is biased against the caster stem and situated within the caster stem notch when the caster stem is in a desired rotational position. The biasing means can also employ magnets located in the caster stem and caster mount which align at opposite attracting poles when the caster is in a desired position.

Abstract: A shock absorption mechanism for a wheelchair includes a caster fork including a first oblique surface and a second horizontally disposed surface, relative to a horizontal plane of travel of the wheelchair. A portion of the second surface includes a curved profile. A joint is mountable adjacent a first section thereof to a frame of the wheelchair and adjacent a second section thereof to the caster fork. The joint includes a first oblique surface and a second surface for guiding reciprocation of the curved profile portion of the caster fork. A shock absorber is disposed in an oblique orientation between the first oblique surface of the caster fork and the first oblique surface of the joint. The caster fork is pivotable adjacent the second section of the joint. The shock absorber is compressable in a direction generally parallel to the oblique orientation thereof during pivoting of the caster fork.

Abstract: A shock absorption mechanism for a wheelchair includes a caster fork including a first oblique surface and a second horizontally disposed surface, relative to a horizontal plane of travel of the wheelchair. A portion of the second surface includes a curved profile. A joint is mountable adjacent a first section thereof to a frame of the wheelchair and adjacent a second section thereof to the caster fork. The joint includes a first oblique surface and a second surface for guiding reciprocation of the curved profile portion of the caster fork. A shock absorber is disposed in an oblique orientation between the first oblique surface of the caster fork and the first oblique surface of the joint. The caster fork is pivotable adjacent the second section of the joint. The shock absorber is compressable in a direction generally parallel to the oblique orientation thereof during pivoting of the caster fork.