Abstract: A container can be used for growing a plant having roots. The container can comprise a rectangular sheet having an upper edge, a lower edge, a first side edge and a second side edge. The first side edge and the second side edge are joined forming a cylinder. The upper edge is configured to rest above a ground surface such that vertical root growth is substantially uninhibited by the container above the ground surface. An inward contoured lip can be formed into the lower edge. The rectangular sheet from the upper edge to the inward contoured lip constrains lateral growth of the roots of the plant above the ground surface while vertical root growth is completely uninhibited by the container below the inward contoured lip.

Abstract: A foldable lighted tree assembly includes an assembly frame with a plurality of elongated assembly frame legs each having a first leg end and a second leg end. The plurality of assembly frame legs converges at the second leg end. The plurality of assembly frame legs are selectively deployable between an extended, functional configuration wherein the assembly frame is generally pyramid-shaped and a folded, non-functional transport and storage configuration wherein the plurality of assembly frame legs are generally parallel and adjacent to each other. At least one light string having a plurality of lights is supported by the assembly frame.

Abstract: A downhole tool, a retrievable bridge plug system, and a method. The downhole tool includes a release mandrel, a plurality of slips disposed at least partially around the release mandrel, an upper cone disposed at least partially around the release mandrel and on a first axial side of the plurality of slips, a lower cone disposed at least partially around the outer mandrel and on a second axial side of the plurality of slips, and a collet positioned axially and radially between the release mandrel and the lower cone. The collet is configured to prevent downward movement of the lower cone relative to the release mandrel at least when the downhole tool is in a run-in configuration and when the downhole tool is in a set configuration.

Abstract: A downhole tool, a retrievable bridge plug system, and a method. The downhole tool includes a release mandrel, a plurality of slips disposed at least partially around the release mandrel, an upper cone disposed at least partially around the release mandrel and on a first axial side of the plurality of slips, a lower cone disposed at least partially around the outer mandrel and on a second axial side of the plurality of slips, and a collet positioned axially and radially between the release mandrel and the lower cone. The collet is configured to prevent downward movement of the lower cone relative to the release mandrel at least when the downhole tool is in a run-in configuration and when the downhole tool is in a set configuration.

Abstract: A system and method for producing thermal spray coatings on a substrate from a liquid suspension is disclosed. The disclosed system and method include a thermal spray torch for generating a plasma and a liquid suspension delivery subsystem for delivering a flow of liquid suspension with sub-micron particles to the plasma to produce a plasma effluent. The liquid suspension delivery subsystem comprises an injector or nozzle which can produce an inert or reactive gas sheath partially or fully surrounding the plasma effluent. A sheath can also be used to isolate injection of the liquid suspension. A gas assist stream can also be employed at or near the suspension injection point. The shroud, sheath or gas assist technique can retain the sub-micron particles entrained within the plasma effluent and substantially prevent entrainment of ambient gases into the plasma effluent.

Abstract: Methods and systems for processing signals to minimize the effects of dye crosstalk. Deconvolution of multiplexed dye signals can include corrections for residual error determined from experimental measurements. Residual error corrections can account for reaction or assay specific factors and modify the subsequent filtering of signals. Correction values can be determined for specific dye-probe conjugates to minimize dye crosstalk and may be combined with residual error correction to further minimize errors in spectral deconvolution. Apparatus, systems, and computer-readable media can process signals and modify filters based on values obtained using the methods.

Abstract: Disclosed is a compound of the formula: and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating protein kinase mediated diseases using the compound of formula 1.0. Also disclosed are methods of treating cancer using a compound of formula 1.0. The disclosed methods also include combination therapies wherein the compound of formula 1.0 is administered in combination with at least one addition pharmaceutically active ingredient.

Abstract: A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, are useful in treating diseases, disorders, or conditions such as immunodeficiencies, cancers, cardiovascular diseases, endocrine disorders, Parkinson's disease, metabolic diseases, tumorigenesis, Alzheimer's disease, heart disease, diabetes, neurodegeneration, inflammation, kidney disease, atherosclerosis and airway disease.

Abstract: In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.

Abstract: Disclosed are methods and compositions that may be used for purifying antibodies.

Abstract: An improved bridge circuit for connecting a disk drive with an ATA interface to a computer via a USB bus. After the bridge receives the first data from the ATA interface, the bridge makes the assumption that the next read command will probably be for the next sequential data word and the interface issues a read command for the next sequential data word. After an accessing delay, the second data word is received by the bridge. When the bridge does in fact receive the next read command from the host, a check is made to see if the second read command is for the next sequential location from the first read command. If it is, the already fetched data is provided to the host without delay. If it is not, the process is handled as was the first read command.

Abstract: A device capable of operating at both a low power mode and at a high power mode which is connected to a host by a USB connection. The device includes a non-volatile memory which stores the operating state of the device when the host goes into hibernate mode and a flag which indicates that the host has entered the “hibernate” mode. When the device powers up, the previous state of the device is read from the memory. If the previous state was high power and the hibernate flag is set, the device restarts in high power mode without the need of any initialization to determine if the host will allow operation at high power speed mode. The device determines that the host is going into suspend mode (rather than power down mode) by determining if a suspend signal on the USB bus is followed by a power down operation.

Abstract: A method for manufacturing encoded microclustered liquids comprising: providing a starting liquid; shielding said liquid from unintentional vibrational and electromagnetic sources; mechanically vortexing said liquid until desired surface tension and zeta-potential are achieved; encoding said liquid with desired vibrational and electromagnetic sources; and bottling said liquid.

Abstract: An intra-convertible thermal vapor extraction and delivery system comprising: an ergonomically-shaped casing comprising a heating element, a fan, an output nozzle thermally coupled to the heating element and having a nozzle base and a tapered nozzle end, and a nozzle sleeve; and a cradle having a bottom surface and a top surface, wherein bottom surface is substantially planar, and top surface is substantially concave so as to accept and securely hold the casing, wherein the fan is positioned substantially behind the heating element so as to blow ambient air through the element, heating it to a desired temperature, and forcing it through the output nozzle, and wherein the nozzle base is positioned to receive the air before the tapered nozzle end, and the nozzle base has a greater outer diameter than the tapered nozzle end, creating a step at the transition between the nozzle base and the tapered nozzle end.

Abstract: Disclosed are methods and compositions that may be used for purifying antibodies.

Abstract: A USB device for communicating data from the device to a USB host is provided. The USB device may have an interrupt or isochronous endpoint for communicating interrupts to the host and a bulk data endpoint for communicating bulk data to the host. The USB device may communicate a signal over the interrupt or isochronous endpoint to the host indicating that the device has bulk data to communicate to the host and may communicate bulk data over the bulk endpoint in response to bulk data requests from the host generated based on the signal over the interrupt or isochronous endpoint.

Abstract: An insertion container is disclosed for use with a traditional type baby bottle with detachable cap and nipple. A preferred embodiment of the container includes a longitudinal tube filled an preferably presealed with a chilled nontoxic liquid such as frozen ice water. The tube is then inserted into a baby bottle and is supported within the bottle by a base rim which is located in the area between the top of the mouth of the bottle and the bottle cap. The base rim can include through holes for allowing baby bottle formula such as milk and the like to flow to the nipple portion of the bottle. Optionally, the base rim can include a rubber type plug to seal the holes and prevent the formula in the bottle from spilling outside the bottle. The elongated insert tube can be sized longer for large bottles and alternatively curve shaped for use with bottles that have a center through hole for gripping the bottle.

Abstract: An apparatus for coating the internal surface of a tubular object having an irregular internal surface which comprises a combination of arms which enable the torch to be in the optimal coating position as it moves over and coats the internal surface.