Patents by Inventor Mark Meisenbach

Mark Meisenbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic method for the preparation of a 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol compound
    Patent number: 11649213
    Abstract: Provided is a process for preparing a compound, comprising the steps of a) Reacting a compound of Formula A (Formula A) with the compound 3 (3) to provide the compound 5 (5) or a salt or solvate thereof, wherein R is a linear or branched C1-C5 alkyl. Further provided is the compound 5 or a salt or solvate thereof. (5) The use of these compounds in the synthesis of 3-[5-Amino-4-(3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: May 16, 2023
    Assignee: MEREO BIOPHARMA 1 LIMITED
    Inventors: Mark Meisenbach, Benjamin Martin, Niek Johannes Ronde, Carmen Ruiz
  • SYNTHETIC METHOD FOR THE PREPARATION OF AN ALKOXYMETHYLENE-BENZOYLACETONITRILE
    Publication number: 20220033352
    Abstract: Provided is a process for preparing a compound of Formula A (Formula A) or a salt or solvate thereof, the process comprising the step of: a) Reacting the compound 1 (1) with a trialkyl orthoformate to provide a compound of Formula A or a salt or solvate thereof, wherein R is the alkyl moiety of the trialkyl orthoformate. Further provided is the compound 2 or a salt or solvate thereof. (2) The use of these compounds in the synthesis of 3-[5-Amino-4-(3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.
    Type: Application
    Filed: September 26, 2019
    Publication date: February 3, 2022
    Applicant: MEREO BIOPHARMA 1 LIMITED
    Inventors: Mark MEISENBACH, Benjamin MARTIN, Niek Johannes RONDE
  • SYNTHETIC METHOD FOR THE PREPARATION OF A 3-[5-AMINO-4-(3-CYANOBENZOYL)- PYRAZOL COMPOUND
    Publication number: 20210395207
    Abstract: Provided is a process for preparing a compound, comprising the steps of a) Reacting a compound of Formula A (Formula A) with the compound 3 (3) to provide the compound 5 (5) or a salt or solvate thereof, wherein R is a linear or branched C1-C5 alkyl. Further provided is the compound 5 or a salt or solvate thereof. (5) The use of these compounds in the synthesis of 3-[5-Amino-4-(3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.
    Type: Application
    Filed: September 26, 2019
    Publication date: December 23, 2021
    Applicant: MEREO BIOPHARMA 1 LIMITED
    Inventors: Mark MEISENBACH, Benjamin MARTIN, Niek Johannes RONDE, Carmen RUIZ
  • N-phenyl-2-pyrimidine-amine derivatives
    Patent number: 9573928
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: February 21, 2017
    Assignee: Novartis AG
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • Somatostatin Analogues
    Publication number: 20150218223
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Application
    Filed: April 8, 2015
    Publication date: August 6, 2015
    Applicant: Novartis AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • Somatostatin analogues
    Patent number: 9035021
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: May 19, 2015
    Assignee: Novartis AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • N-Phenyl-2-pyrimidine-amine Derivatives
    Publication number: 20150018552
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Application
    Filed: September 30, 2014
    Publication date: January 15, 2015
    Applicant: Novartis AG
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • Somatostatin analogues
    Patent number: 8822637
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O-)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: September 2, 2014
    Assignee: Novartis AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • N-Phenyl-2-pyrimidine-amine Derivatives
    Publication number: 20120226039
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Application
    Filed: May 17, 2012
    Publication date: September 6, 2012
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • Process for the synthesis of organic compounds
    Patent number: 8008504
    Abstract: The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: August 30, 2011
    Assignee: Novartis AG
    Inventors: Stephan Abel, Murat Acemoglu, Bernhard Erb, Christoph Krell, Joseph Sclafani, Mark Meisenbach, Mahavir Prashad, Wen-Chung Shieh, Song Xue
  • SOMATOSTATIN ANALOGUES
    Publication number: 20110172157
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Application
    Filed: March 16, 2011
    Publication date: July 14, 2011
    Applicant: NOVARTIS AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • SOMATOSTATIN ANALOGUES
    Publication number: 20110166320
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Application
    Filed: March 16, 2011
    Publication date: July 7, 2011
    Applicant: NOVARTIS AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • Somatostatin analogues
    Patent number: 7939625
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: May 10, 2011
    Assignee: Novartis AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld
  • PROCESS FOR THE SYNTHESIS OF ORGANIC COMPOUNDS
    Publication number: 20100280257
    Abstract: The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):
    Type: Application
    Filed: July 12, 2010
    Publication date: November 4, 2010
    Inventors: Stephan Abel, Murat Acemoglu, Bernhard Erb, Christoph Krell, Joseph Sclafani, Mark Meisenbach, Mahavir Prashad, Wen-Chung Shieh, Song Xue
  • N-phenyl-2-pyrimidine-amine derivatives
    Patent number: 7825247
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: November 2, 2010
    Assignee: Novartis AG
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • N-phenyl-2-pyrimidine-amine derivatives
    Patent number: 7816359
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: October 19, 2010
    Assignee: Novartis AG
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • Process for the synthesis of organic compounds
    Patent number: 7781597
    Abstract: The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: August 24, 2010
    Assignee: Novartis AG
    Inventors: Stephan Abel, Murat Acemoglu, Bernhard Erb, Christoph Krell, Joseph Sclafani, Mark Meisenbach, Mahavir Prashad, Wen-Chung Shieh, Song Xue
  • -phenyl-2-pyrimidine-amine derivatives
    Patent number: 7579467
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: August 25, 2009
    Assignee: Novartis AG
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • N-PHENYL-2-PYRIMIDINE-AMINE DERIVATIVES
    Publication number: 20090137805
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Application
    Filed: February 2, 2009
    Publication date: May 28, 2009
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Burger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • SOMATOSTATIN ANALOGUES
    Publication number: 20090069225
    Abstract: The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
    Type: Application
    Filed: November 5, 2008
    Publication date: March 12, 2009
    Applicant: NOVARTIS AG
    Inventors: Rainer Albert, Wilfried Bauer, David Bodmer, Christian Bruns, Ivo Felner, Heribert Hellstern, Ian Lewis, Mark Meisenbach, Gisbert Weckbecker, Bernhard Wietfeld