Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.

Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.

Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.

Abstract: A sanitation system comprising of a first tank for receiving waste water fluid typically comprising solids, a maceration pump for pulling waste water fluid from the first tank, a cross flow filter comprising of media for receiving the sheared fluid forming unfiltered waste water and product water, a second tank for receiving the product water from a product water manifold connected to the second segment, a vented loop in communication with the second tank for receiving raw water and displacing product water from the second tank, a macerating water jet adapted to pull product water into the vented loop and on demand further macerate the product water, then into a third tank for receiving water from the vented loop and raw water for de-chlorinating the product water, and a control panel comprising a microprocessor to optimize the operation of the sanitation system.

Abstract: This invention relates to novel intermediates and processes for preparing pharmaceutically active quinoline compounds, including (?)-(S)—N-(?-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.

Abstract: This invention relates to novel intermediates and processes for preparing phamaceutically active quinoline compounds, including (?)-(S)-N-(?-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.

Abstract: A centrifugal multistage stage pumps described herein. The centrifugal multistage pump includes a pump body having a longitudinal axis, an inlet for receiving a fluid from a first location and an outlet for discharging a pressurized fluid to a second location and a hydraulic assembly disposed within the pump body and adapted to pressurize the fluid. The pump further includes a motor, a first circuit board inverter disposed within the pump body, a microcontroller disposed on the first circuit board inverter, a pressure transducer disposed within the pump body, a heat sink adjacent the first circuit board inverter, a control panel connected to the circuit board inverter and the microcontroller. The pump has a mounting system adapted for rotation of the pump body around the longitudinal axis. In addition, the pump includes software imbedded within the memory, wherein the software includes protection, monitoring and control the features of the pump.

Abstract: This invention relates to novel intermediates and processes for preparing pharmaceutically active quinoline compounds, including (−)-(S)-N-(&agr;-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.

Abstract: This invention relates to novel intermediates and processes for preparing phamaceutically active quinoline compounds, including (−)-(S)-N-(&agr;-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.

Abstract: P50713 This invention relates to novel intermediates and processes for preparing phamaceutically active quinoline compounds, including (−)-(S)-N-(&agr;-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.

Abstract: This invention relates to novel intermediates and processes for preparing pharmaceutically active quinoline compounds, including (−)-(S)-N-(&agr;-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.

Abstract: An apparatus and method for thermally coupling a heat sink directly to a surface mount heat generating device package in a manner which provides a more efficient thermal path between the heat sink and the device package, and which allows for a simplified assembly process. The heat sink is mounted in direct thermal communication with the heat generating device package which is surface mounted to a printed circuit board or other substrate. The inventive heat sink has a reservoir of thermal preform which allows the heat sink to be secured to a device package at the same time as the device package is being secured to the surface mount substrate, as opposed to doing so in a separate step in the assembly process after the electronic device packages have already been secured to the surface mount substrate. The inventive heat sink thereby simplifies the assembly process by eliminating steps in the manufacturing process and by allowing for the further automation of the assembly process.

Abstract: A process for the preparation of water soluble camptothecin analogs, including methods for the preparation of intermediates thereof, and the compounds prepared by said process. Water soluble camptothecin analogs are prepared which may be used for inhibiting the growth of tumor cells sensitive to such analogs.

Abstract: A method for making 8-methyl-7-(1-oxopropyl)indolizino[1,2-b]quinolin-9(11H)-ones from 4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-3,14(4H,12 H)-diones, said method being graphically illustrated as follows: ##STR1##