Patents by Inventor Mark MIDEI

Mark MIDEI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prophylactic Methods For Treating ALS
    Publication number: 20250213516
    Abstract: Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal neurodegenerative disease in humans. The underlying hallmarks of the disease involve lipid peroxidation (LPO) of polyunsaturated fatty acids (PUFAs) in the motor neurons. Central to this oxidative pathway is the presence of labile bis-allylic hydrogen atoms found in arachidonic acid, the dominant PUFA found in neurons. Disclosed are prophylactic methods for delaying the onset of the accelerated loss of functionality in patients suffering from ALS in humans. The methods comprise use of a deuterated arachidonic acid or a prodrug thereof.
    Type: Application
    Filed: March 30, 2023
    Publication date: July 3, 2025
    Inventors: Peter Milner, Nadia Litterman, Mark Midei
  • SYNERGISTIC COMBINATION THERAPY FOR TREATING ALS
    Publication number: 20240382456
    Abstract: Disclosed are methods for inhibiting the progression of amyotrophic lateral sclerosis (ALS) in humans. The methods use a synergistic combination of 2,4-dihydro-3H-pyrazol-3-one and deuterated arachidonic acid or a prodrug thereof, such as 11,11-D2-linoleic acid or an ester thereof.
    Type: Application
    Filed: December 15, 2023
    Publication date: November 21, 2024
    Inventors: Peter Milner, Nadia Litterman, Mark Midei
  • Synergistic combination therapy for treating ALS
    Patent number: 12109194
    Abstract: Disclosed are methods for inhibiting the progression of amyotrophic lateral sclerosis (ALS) in humans. The methods use a synergistic combination of 3-methyl-1-phenyl-2-pyrazoline-5-one and deuterated arachidonic acid or a prodrug thereof, such as 11,11-D2-linoleic acid or an ester thereof.
    Type: Grant
    Filed: March 1, 2022
    Date of Patent: October 8, 2024
    Assignee: BioJiva LLC
    Inventors: Peter Milner, Nadia Litterman, Mark Midei
  • SYNERGISTIC COMBINATION THERAPY FOR TREATING ALS
    Publication number: 20220249442
    Abstract: Disclosed are methods for inhibiting the progression of amyotrophic lateral sclerosis (ALS) in humans. The methods use a synergistic combination of 2,4-dihydro-3H-pyrazol-3-one and deuterated arachidonic acid or a prodrug thereof, such as 11,11-D2-linoleic acid or an ester thereof.
    Type: Application
    Filed: March 1, 2022
    Publication date: August 11, 2022
    Inventors: Peter MILNER, Nadia LITTERMAN, Mark MIDEI