Abstract: This disclosure provides a multi-target fusion protein composed of a TNF-? antagonist domain and another binding domain antagonistic for a heterologous target, such as IL6, RANKL, IL7, IL17A/F, TWEAK, CSF2, IGF1, IGF2 or BLyS/APRIL, or agonistic for a heterologous target, such as IL10. The multi-specific fusion protein may also include an intervening domain that separates the binding domains and allows for dimerization. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.

Abstract: An apparatus and process are provided for discharging a dose of a molten metal from a pressure pour furnace. A heating chamber of the furnace is used to keep the molten metal at a selected temperature. A sealing port between the heating chamber and a pressure chamber allows selectively filling of the pressure chamber with molten metal from the heating chamber by inserting or removing a sealing means from the sealing port. The sealing means inserted in the sealing port also provides a means for preventing back flow of the molten metal to the heating chamber when the pressure chamber is pressurized. Differential pressure sensing of the pressure of the molten metal in the pressure chamber and the pressure of the pressurizing gas in the pressure chamber can optionally be used to achieve an accurate measured discharge from the pressure chamber as the level of molten metal decreases from repeated discharges of doses from the furnace.