Abstract: This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.

Abstract: Provided is a manually operated wash station that can simultaneously apply a wash process to multiple cells of a multi-well synthesis reactor plate. Further provided is a manually operated wash station that can be adapted to automatic computer control. A method for simultaneously washing a plurality of wells in a multi-well container is provided. Additionally, a method for purifying a plurality of chemical products simultaneously in a multi-well reactor plate.

Abstract: A clamping system including a cover plate with an underside having at least one step, and a bottom plate having a base connected to a first side, a second side, a third side, and a fourth side. The bottom plate also has a well for receiving a reactor plate. The clamping system further includes a compression skirt positioned between the cover plate and the bottom plate, with the compression skirt having a first side, a second side, a third side, and a fourth side corresponding to the first, second, third, and fourth sides of the bottom plate, respectively. Additionally, the clamping system includes a first and a second upper latch assembly for clamping the cover plate to the compression skirt, and a first and a second lower latch assembly for clamping the compression skirt to the bottom plate.