Patents by Inventor Mark N. Namchuk

Mark N. Namchuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for modulating IL-10 immunostimulatory and anti-inflammatory properties
    Patent number: 11534480
    Abstract: The invention provides compositions and methods for modulating the immunostimulatory properties and/or anti-inflammatory properties of IL-10. The present invention provides scIL-10 polypeptides of Formula 1. The polypeptides of the invention are optionally linked to a fusion partner. The polypeptides of Formula 1 are referred to herein as “scIL-10” polypeptides and comprise an amino acid sequence arrangement from N-terminus to C-terminus in accordance with Formula 1: (first monomer subunit)-LINKER-(second monomer subunit)?? Formula 1 wherein the first monomer subunit, the second monomer subunit or both the first and second monomer subunits may be independently selected from: an unsubstituted IL-10 monomer subunit; or a substituted IL-10 monomer subunit comprising at least one amino acid substitution; and wherein LINKER is any amino acid linker of at least 1-100 amino acids in length.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: December 27, 2022
    Assignee: ALKERMES, INC.
    Inventors: Demetri T. Moustakas, Mark N. Namchuk, Heather C. Losey, Juan C. Alvarez
  • Compositions and Methods for Modulating IL-10 Immunostimulatory and Anti-Inflammatory Properties
    Publication number: 20190336582
    Abstract: The invention provides compositions and methods for modulating the immunostimulatory properties and/or anti-inflammatory properties of IL-10. The present invention provides scIL-10 polypeptides of Formula 1. The polypeptides of the invention are optionally linked to a fusion partner. The polypeptides of Formula 1 are referred to herein as “scIL-10” polypeptides and comprise an amino acid sequence arrangement from N-terminus to C-terminus in accordance with Formula 1: (first monomer subunit)-LINKER-(second monomer subunit)?? Formula 1 wherein the first monomer subunit, the second monomer subunit or both the first and second monomer subunits may be independently selected from: an unsubstituted IL-10 monomer subunit; or a substituted IL-10 monomer subunit comprising at least one amino acid substitution; and wherein LINKER is any amino acid linker of at least 1-100 amino acids in length.
    Type: Application
    Filed: May 16, 2019
    Publication date: November 7, 2019
    Inventors: Demetri T. Moustakas, Mark N. Namchuk, Heather C. Losey, Juan C. Alvarez
  • Compositions for modulating IL-10 immunostimulatory and anti-inflammatory properties
    Patent number: 10335459
    Abstract: The invention provides compositions and methods for modulating the immunostimulatory properties and/or anti-inflammatory properties of IL-10. The present invention provides scIL-10 polypeptides of Formula 1. The polypeptides of the invention are optionally linked to a fusion partner. The polypeptides of Formula 1 are referred to herein as “scIL-10” polypeptides and comprise an amino acid sequence arrangement from N-terminus to C-terminus in accordance with Formula 1: (first monomer subunit)-LINKER-(second monomer subunit)?? Formula 1 wherein the first monomer subunit, the second monomer subunit or both the first and second monomer subunits may be independently selected from: an unsubstituted IL-10 monomer subunit; or a substituted IL-10 monomer subunit comprising at least one amino acid substitution; and wherein LINKER is any amino acid linker of at least 1-100 amino acids in length.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: July 2, 2019
    Assignee: Alkermes, Inc.
    Inventors: Demetri T. Moustakas, Mark N. Namchuk, Heather C. Losey, Juan C. Alvarez
  • COMPOSITIONS AND METHODS FOR MODULATING IL-10 IMMUNOSTIMULATORY AND ANTI-INFLAMMATORY PROPERTIES
    Publication number: 20170368144
    Abstract: The invention provides compositions and methods for modulating the immunostimulatory properties and/or anti-inflammatory properties of IL-10. The present invention provides scIL-10 polypeptides of Formula 1. The polypeptides of the invention are optionally linked to a fusion partner. The polypeptides of Formula 1 are referred to herein as “scIL-10” polypeptides and comprise an amino acid sequence arrangement from N-terminus to C-terminus in accordance with Formula 1: (first monomer subunit)-LINKER-(second monomer subunit)?? Formula 1 wherein the first monomer subunit, the second monomer subunit or both the first and second monomer subunits may be independently selected from: an unsubstituted IL-10 monomer subunit; or a substituted IL-10 monomer subunit comprising at least one amino acid substitution; and wherein LINKER is any amino acid linker of at least 1-100 amino acids in length.
    Type: Application
    Filed: June 22, 2017
    Publication date: December 28, 2017
    Inventors: Demetri T. Moustakas, Mark N. Namchuk, Heather C. Losey, Juan C. Alvarez