Abstract: Devices, systems and methods for needle free injection include a multi-use needle-free injection device comprising reversibly connected proximate and distal sections, wherein the proximate section comprises a power supply, actuator, circuitry and a housing, and the distal section comprises a disposable nozzle tip prefilled with an injectate, a chemical energetic device, and a dual seal piston barrier between the energetic device and the injectate, wherein the proximate and distal sections and their components are operably linked and configured for single-hand injecting of the injectate.