Abstract: Macrolide compounds per se, as shown below and defined herein, and their use, e.g., as antibacterial and antiprotozoal agents in animals, including humans: Also disclosed are methods of preparing the compounds, intermediates, and pharmaceutical compositions thereof, and methods of treating or preventing disease by administering the compounds to subjects in need. This abstract is only an excerpt and is not limiting of the invention.

Abstract: A turbine engine shroud segment comprises a body including an outer surface away from which an integral attachment system projects. The attachment system comprises a plurality of at least two axially spaced apart circumferentially extending rows of discrete projection hook segments to interrupt a potential hoop stress path through the attachment system. Each projection hook segment includes a segment support surface aligned circumferentially and radially with other segment support surfaces in a row.

Abstract: A collar seal is configured for a turbine nozzle vane. The seal includes a retainer having a circumferential airfoil contour conforming with the airfoil contour of the vane. A flexible leaf is surrounded by the retainer and fixedly joined thereto. A woven sheath encases the leaf and is fixedly joined to the retainer. In an exemplary embodiment, the collar seal surrounds one end of a ceramic turbine vane mounted in a metal supporting band.

Abstract: This invention relates to a method of treatment for osteoarthritis involving inhibitors of aggrecanase that demonstrate IC50s of less than 20 nM and demonstrate differential potency against matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs or reprolysins).

Abstract: A compound of the formula wherein R1, R2 R3, R4, R5, R6 and Q are as defined above, useful in the treatment of arthritis, cancer, and other diseases involving the dysregulated production/release of reprolysins such as TNF and other diseases characterized by matrix metalloproteinase activity. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID's), COX-2 inhibitors and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.

Abstract: The present invention relates to 5-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said “A” is a 5-7 membered heterocyclic ring as defined in the specification and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

Abstract: The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, Y, A, B and R1 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

Abstract: An assembly for mounting an igniter in a gas turbine engine combustor between an outer casing and an outer liner, wherein a longitudinal centerline axis extends through the gas turbine engine. The igniter mounting assembly includes a first spring member encircling a portion of said igniter and being positioned between a surface adjacent the outer casing and an outer surface of the outer liner, a first ring member connected to a first end of the first spring member adjacent the outer surface of the outer liner, and a second ring member connected to a second end of the first spring member adjacent the surface adjacent the outer casing. Accordingly, the igniter is able to maintain substantial alignment with respect to an opening in the outer liner while moving radially and/or axially with respect to the outer liner as the outer casing experiences thermal growth greater than the outer liner.