Abstract: A disc brake guide assembly having a guide bush, a closure, and a stop. The guide bush may be mountable in a through bore of a support. The closure may be a barrier to the ingress of foreign matter into the through bore. The stop may restrict axial displacement of the guide bush.

Abstract: A machine tool head for machining internal surfaces of a cavity defined by a monobloc caliper for a disc brake assembly. The tool head is an angle head comprising a cutter for machining said internal surfaces and a drive train configured to connect the cutter to an actuator. The cutter comprises a first cutting edge configured for cutting as the tool head is moved in a first direction and a second cutting edge configured for cutting as the tool head is moved in a second direction.

Abstract: A disc brake guide assembly having a guide bush, a closure, and a stop. The guide bush may be mountable in a through bore of a support. The closure may be a barrier to the ingress of foreign matter into the through bore. The stop may restrict axial displacement of the guide bush.

Abstract: Systems and methods for data localization and anonymization are provided herein. In some embodiments, systems and methods for data localization and anonymization may include receiving a communication request to send a message or establish a call between a first service provider and an end user device associated with an end user, determining that the communication request is associated with a requirement for securing personally identifiable information (PII) of the end user, and processing the communication request based on the requirement for securing the PII of the end user, wherein the requirement includes at least one of (A) localization of the communication request processing or (B) anonymization of any data records associated with the communication request that includes the PII of end user.

Abstract: Systems and methods for data localization and anonymization are provided herein. In some embodiments, systems and methods for data localization and anonymization may include receiving a communication request to send a message or establish a call between a first service provider and an end user device associated with an end user, determining that the communication request is associated with a requirement for securing personally identifiable information (PII) of the end user, and processing the communication request based on the requirement for securing the PII of the end user, wherein the requirement includes at least one of (A) localization of the communication request processing or (B) anonymization of any data records associated with the communication request that includes the PII of end user.

Abstract: A disc brake having a caliper, a piston, an operating shaft, a wear adjustment mechanism, and a transmission path. The caliper may straddle a rotor and may retain first and second brake pads. The piston may be slidable within the caliper. The operating shaft may apply an actuating force to advance the piston when the operating shaft is actuated. The transmission path of the wear adjustment mechanism may include a one-way clutch.

Abstract: A disc brake having a caliper, a housing bore, a guide insert, and a piston. The housing bore extends inboard from an outboard face of a housing portion of the caliper. The guide insert may have an inner guide bore and may be mounted within the housing bore. The piston may be slideable within the inner guide bore relative to the guide insert so as to urge a brake pad towards a rotor.

Abstract: A brake includes a brake shoe moveable between an engaged position and a disengaged position and defining an axis of rotation of an associated brake drum. The brake includes an actuation shaft rotatable about a shaft axis and an actuation device for transferring rotational movement of the actuation shaft into movement of the brake shoe from the disengaged position to the engaged position. The axis of rotation is non-parallel to the shaft axis.

Abstract: A disc brake having a caliper, a piston, an operating shaft, a wear adjustment mechanism, and a transmission path. The caliper may straddle a rotor and may retain first and second brake pads. The piston may be slidable within the caliper. The operating shaft may apply an actuating force to advance the piston when the operating shaft is actuated. The transmission path of the wear adjustment mechanism may include a one-way clutch.

Abstract: A disc brake having a caliper, a housing bore, a guide insert, and a piston. The housing bore extends inboard from an outboard face of a housing portion of the caliper. The guide insert may have an inner guide bore and may be mounted within the housing bore. The piston may be slideable within the inner guide bore relative to the guide insert so as to urge a brake pad towards a rotor.

Abstract: A brake includes a brake shoe moveable between an engaged position and a disengaged position and defining an axis of rotation of an associated brake drum. The brake includes an actuation shaft rotatable about a shaft axis and an actuation device for transferring rotational movement of the actuation shaft into movement of the brake shoe from the disengaged position to the engaged position. The axis of rotation is non-parallel to the shaft axis.

Abstract: An injection nozzle for an internal combustion engine has a valve member (10) with a seating line (112) defining a seat diameter, the seating line (112) being engageable with a seating surface (14) to control fuel injection by the nozzle, in use. The seating line is defined by an annular ridge (40, 44, 46), integrally formed with the valve needle (10), so as to reduce variations in the seat diameter which would otherwise arise at manufacture due to contact between the valve needle (10) and the seating surface (14) in regions other than at the seating line. The invention provides an advantage in manufacture as repeatability and consistency of the geometry, and in particular the effective seat diameter, of nozzle products is improved.

Abstract: An injection nozzle for an internal combustion engine has a valve member (10) with a seating line (112) defining a seat diameter, the seating line (112) being engageable with a seating surface (14) to control fuel injection by the nozzle, in use. The seating line is defined by an annular ridge (40, 44, 46), integrally formed with the valve needle (10), so as to reduce variations in the seat diameter which would otherwise arise at manufacture due to contact between the valve needle (10) and the seating surface (14) in regions other than at the seating line. The invention provides an advantage in manufacture as repeatability and consistency of the geometry, and in particular the effective seat diameter, of nozzle products is improved.

Abstract: Selected substituted piperazine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Abstract: Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duoden

Abstract: Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Abstract: Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also realtes to processes for making such compounds as well as to intermediates useful in such processes.

Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, d

Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, d

Abstract: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, d