Abstract: A method of analysing streams of metric data from a plurality of data processing sources (2) in a parallel processing system (1), using a computer (6). Each stream includes time stamped data associated with the respective data processing source in respect of a given metric which is sampled at intervals. For each stream of data, a start time and an end time are identified. A normalized start time and a normalized end time are determined across all streams. Sampling points are specified between the normalized start time and the normalized end time. For each stream of data, the data is re-sampled at the specified sampling points. For each sampling point, the re-sampled data across all the streams of data is processed to determine a statistical derivative of the data. A report is displayed which represents the values of the statistical derivative as a function of time. The process may be applied to various different metrics, and the results displayed at the same time, on a common time axis.

Abstract: A method of analysing streams of metric data from a plurality of data processing sources (2) in a parallel processing system (1), using a computer (6). Each stream includes time stamped data associated with the respective data processing source in respect of a given metric which is sampled at intervals. For each stream of data, a start time and an end time are identified. A normalized start time and a normalized end time are determined across all streams. Sampling points are specified between the normalized start time and the normalized end time. For each stream of data, the data is re-sampled at the specified sampling points. For each sampling point, the re-sampled data across all the streams of data is processed to determine a statistical derivative of the data. A report is displayed which represents the values of the statistical derivative as a function of time. The process may be applied to various different metrics, and the results displayed at the same time, on a common time axis.

Abstract: The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.

Abstract: DNA Damage Repair Inhibitors for Treatment of Cancer The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.

Abstract: A multi-channel transparent jacket for accommodating strips of microfilm to create a microfiche, the jacket having non-blocking characteristics, thereby minimizing the tendency of one jacket in a stack thereof to stick to an adjacent jacket. The jacket is constituted by front and rear panels formed of flexible polyethylene terephthalate film joined together by a parallel array of ribs to define the channels. The exposed surfaces of the panels have a friction-reducing layer thereon constituted by a multiplicity of discrete silicon dioxide nodules bonded to the film, the nodule shape approximating a surface segment of a sphere. The peaks of the segments form microscopic contact points which are bonded by molecular attraction to an abutting panel when the jacket is juxtaposed against a like jacket in frictional relationship thereto.

Abstract: A single-channel microfiche master housing a strip of microfilm containing one or more frames of reduced scale images, the master being manipulatable in one axial direction only by optical readers and other microfiche-handling machines. The master is constituted by a rectangular tab having a pair of keyhole notches at spaced positions in the lower edge thereof and a single channel transparent jacket accommodating the microfilm strip, one end of the jacket being secured to the tab at a position intermediate the notches to form a T-shaped structure. The microfiche master may be stored in a standard pull-out drawer by a raised pair of rails which is bridged by the tab, the rails passing through the notches whereby the jacket is suspended therebelow in the drawer.