Patents by Inventor Mark O. Goodarzi

Mark O. Goodarzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PROGNOSING HEART TRANSPLANT
    Publication number: 20170240965
    Abstract: Provided herein is a method, comprising: obtaining a sample from the subject; assaying the sample to detect the risk alleles at one or more SNPs; calculating a genetic risk score (GRS) of the subject based on the detected risk alleles at the one or more SNPs; determining that the subject has an increased likelihood of poor prognosis if the GRS of the subject is above the mean or median GRS of the sample population or determining that the subject has an increased likelihood of good prognosis if the GRS of the subject is the same as or above the mean or median GRS of the sample population; and selecting a therapy if poor prognosis is determined.
    Type: Application
    Filed: February 22, 2017
    Publication date: August 24, 2017
    Applicant: Cedars-Sinai Medical Center
    Inventors: Bernice Coleman, Mark O. Goodarzi, Jon Kobashigawa
  • Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
    Patent number: 8178294
    Abstract: Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically significant association with a phenotype of interest, such as insulin resistance or coronary artery disease. Thus, also disclosed are a method of detecting a genetic predisposition in a human subject for certain biological conditions, which may be related to coronary artery disease.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: May 15, 2012
    Assignee: Cedars-Sinai Medical Center
    Inventors: Kent D. Taylor, Jerome I. Rotter, Huiying Yang, Willa A. Hsueh, Xiuqing Guo, Leslie J. Raffel, Mark O. Goodarzi, Yii-Der Ida Chen
  • METHODS OF DIAGNOSING INSULIN RESISTANCE AND SENSITIVITY
    Publication number: 20120088245
    Abstract: Methods of diagnosing susceptibility to metabolic insulin resistance and other related conditions are disclosed. The method provides means of diagnosing susceptibility to insulin resistance in Hispanic Americans by determining the presence of a risk haplotype at the LPL locus, the LPIN1 locus, and/or elevated levels of gamma-glutamyl transferase.
    Type: Application
    Filed: October 30, 2009
    Publication date: April 12, 2012
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Jerome I. Rotter, Kent D. Taylor, Xiuqing Guo, Mark O. Goodarzi, Yii-Der I. Chen, Leslie Raffel, Thomas A. Buchanan, Anny Xiang
  • LIPOPROTEIN LIPASE AND ITS EFFECT ON STATIN TREATMENTS
    Publication number: 20100130600
    Abstract: The invention provides methods of treating and prognosing atherosclerosis and lipid response to statin treatment by determining the presence or absence of haplotypes at the lipoprotein lipase locus. In one embodiment, the invention is practiced by evaluating the prognosis of vascular grafts in an individual undergoing statin treatment by determining the presence or absence of haplotypes at the lipoprotein locus.
    Type: Application
    Filed: March 28, 2008
    Publication date: May 27, 2010
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Mark O. Goodarzi, Kent D. Taylor, Maren T. Scheuner, Xiuqing Guo, Prediman K. Shah, Jerome I. Rotter
  • Method of haplotype-based genetic analysis for determining risk for developing insulin resistance and coronary artery disease
    Patent number: 7141373
    Abstract: Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically significant association with a phenotype of interest, such as insulin resistance or coronary artery disease. Thus, also disclosed are a method of detecting a genetic predisposition in a Mexican-American human subject for developing insulin resistance and methods of detecting a lower than normal risk in a Mexican-American human subject for developing insulin resistance or coronary artery disease.
    Type: Grant
    Filed: June 16, 2003
    Date of Patent: November 28, 2006
    Assignees: Cedars-Sinai Medical Center, The Regents of the University of California
    Inventors: Kent D. Taylor, Jerome I. Rotter, Huiying Yang, Willa A. Hsueh, Xiuqing Guo, Leslie J. Raffel, Mark O. Goodarzi
  • Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
    Publication number: 20040076988
    Abstract: Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically significant association with a phenotype of interest, such as insulin resistance or coronary artery disease. Thus, also disclosed are a method of detecting a genetic predisposition in a Mexican-American human subject for developing insulin resistance and methods of detecting a lower than normal risk in a Mexican-American human subject for developing insulin resistance or coronary artery disease.
    Type: Application
    Filed: June 16, 2003
    Publication date: April 22, 2004
    Inventors: Kent D. Taylor, Jerome I. Rotter, Huiying Yang, Willa A. Hsueh, Xiuqing Guo, Leslie J. Raffel, Mark O. Goodarzi