Abstract: Compounds and berberine compositions containing such compounds that are useful for reducing nicotine dependency. Methods for administering the berberine compositions are also disclosed. The compounds may have a structure according to Formula (I). In Formula (I) R1, R2, R3, R4, and R5 are independently H or D; R6 and R7 are independently hydrogen, deuterium, halogen, C4 to C8 unsubstituted aryl, C4 to C8 substituted aryl, C2 to C6 unsubstituted heterocycle, C2 to C6 substituted heterocycle, C1 to C6 unsubstituted alkyl, C1 to C6 substituted alkyl, C3-C10 unsubstituted cycloalkyl, C3-C10 substituted cycloalkyl, or R6 and R7 are taken together as ?O or ?S; and R8 and R9 are independently selected from a group consisting of methyl, CHF2, and CF3.

Abstract: A method of operating an HVAC system using a controller includes predicting a first predicted temperature of an enclosed space during an unoccupied time with the HVAC system off. The controller determines if the first predicted temperature is less than a set-point temperature. Responsive to a determination that the first predicted temperature is less than the set-point temperature, the controller predicts a second predicted temperature of the enclosed space if the HVAC system is operated for a first runtime. The controller determines if the second predicted temperature is less than the set-point temperature and, responsive to a determination that the second predicted temperature is not less than the set-point temperature, the controller operates the HVAC system for the first runtime.

Abstract: There is disclosed a system for secure remote work. An associated client computer may receive a login attempt from a user, provide login credentials received from a user to a remote computing device for authentication. The client computer may then receive confirmation of authentication along with a request for security protocol testing in conformity with security requirements for access to a secure remote work environment, perform security protocol testing on the client computing device, and provide security protocol test results generated by the security protocol testing to the remote computing device. Thereafter, the remote client may access to the secure remote work environment upon confirmation that the security protocol test results pass the security protocol testing.

Abstract: A refrigerant detector testing system according to aspects of the disclosure includes a metering orifice formed in a suction line that is disposed between an evaporator coil and a compressor, a valve fluidly coupled to the metering orifice, a connecting tube fluidly coupled to the valve on a side opposite the metering orifice, a mixing device having an input orifice fluidly coupled to the connecting tube. In some embodiments, the mixing device includes an air intake disposed proximate the input orifice, a throttling portion downstream of the input orifice and the air intake, the throttling portion having a reduced cross-sectional area, and a diffuser section positioned downstream of the throttling portion, the diffuser section having an output orifice. According to aspects of the disclosure, a refrigerant detector fluidly exposed to the output orifice.

Abstract: Monoclonal antibodies (MAbs) targeting one or more specific epitopes of aspartyl (asparaginyl) hydroxylase (ASPH), including humanized, bi-specific, and other chimeric MAb variants, and fragments thereof (collectively ASPH epitope-specific MAbs, or simply ASPH MAbs), are disclosed. Methods of production, purification, and use of the ASPH epitope-specific MAbs, and compositions comprising them, as agents in therapeutic and diagnostic applications to interact with target molecules in cell-free samples, cell- and tissue-based assays, animal models, and in a subject are also disclosed. Other aspects of the invention relate to use of the molecules disclosed herein to diagnose, ameliorate, or treat cell proliferation disorders and related diseases.

Abstract: A method of operating an HVAC system using a controller includes predicting a first predicted temperature of an enclosed space during an unoccupied time with the HVAC system off. The controller determines if the first predicted temperature is less than a set-point temperature. Responsive to a determination that the first predicted temperature is less than the set-point temperature, the controller predicts a second predicted temperature of the enclosed space if the HVAC system is operated for a first runtime. The controller determines if the second predicted temperature is less than the set-point temperature and, responsive to a determination that the second predicted temperature is not less than the set-point temperature, the controller operates the HVAC system for the first runtime.

Abstract: A method of operating an HVAC system using a controller includes predicting a first predicted temperature of an enclosed space during an unoccupied time with the HVAC system off. The controller determines if the first predicted temperature is less than a set-point temperature. Responsive to a determination that the first predicted temperature is less than the set-point temperature, the controller predicts a second predicted temperature of the enclosed space if the HVAC system is operated for a first runtime. The controller determines if the second predicted temperature is less than the set-point temperature and, responsive to a determination that the second predicted temperature is not less than the set-point temperature, the controller operates the HVAC system for the first runtime.

Abstract: An easily portable and quick to assemble and disassemble windscreen for use with a vehicle such as a snowmobile or all-terrain vehicle.

Abstract: In various implementations, a heat exchanger system may include one or more flow paths. At least one of the flow paths may be associated with more than one pass and/or fluid flow through the flow path may be restricted. A setting of the heat exchanger system may include associations between flow path(s) and/or pass(es). A setting for the heat exchanger system may be determined, and the heat exchanger system may be allowed to operate in the determined setting, in some implementations.

Abstract: An easily portable and quick to assemble and disassemble windscreen for use with a vehicle such as a snowmobile or all-terrain vehicle.

Abstract: A refrigerant detector testing system according to aspects of the disclosure includes a metering orifice formed in a suction line that is disposed between an evaporator coil and a compressor, a valve fluidly coupled to the metering orifice, a connecting tube fluidly coupled to the valve on a side opposite the metering orifice, a mixing device having an input orifice fluidly coupled to the connecting tube. In some embodiments, the mixing device includes an air intake disposed proximate the input orifice, a throttling portion downstream of the input orifice and the air intake, the throttling portion having a reduced cross-sectional area, and a diffuser section positioned downstream of the throttling portion, the diffuser section having an output orifice. According to aspects of the disclosure, a refrigerant detector fluidly exposed to the output orifice.

Abstract: A refrigerant detector testing system according to aspects of the disclosure includes a metering orifice formed in a suction line that is disposed between an evaporator coil and a compressor, a valve fluidly coupled to the metering orifice, a connecting tube fluidly coupled to the valve on a side opposite the metering orifice, a mixing device having an input orifice fluidly coupled to the connecting tube. In some embodiments, the mixing device includes an air intake disposed proximate the input orifice, a throttling portion downstream of the input orifice and the air intake, the throttling portion having a reduced cross-sectional area, and a diffuser section positioned downstream of the throttling portion, the diffuser section having an output orifice. According to aspects of the disclosure, a refrigerant detector fluidly exposed to the output orifice.

Abstract: Methods are disclosed for providing a connected context based experience to a user during a traveling event. A processing system including a processor detects a start of a traveling event for a user, establishes a context data sharing community for the traveling event, wherein the context data sharing community comprises at least one context data source device and a plurality of service agents, where each service agent is expected to provide a service to the user for a duration specified for the traveling event, determines at least one recommendation or at least one action from context data associated with the user received from the at least one context data source device, wherein the context data comprises a purpose of the user for the traveling event, and provides the at least one recommendation to at least one service agent of the plurality of service agents for presentation to the user.

Abstract: A method of operating an HVAC system using a controller includes predicting a first predicted temperature of an enclosed space during an unoccupied time with the HVAC system off. The controller determines if the first predicted temperature is less than a set-point temperature. Responsive to a determination that the first predicted temperature is less than the set-point temperature, the controller predicts a second predicted temperature of the enclosed space if the HVAC system is operated for a first runtime. The controller determines if the second predicted temperature is less than the set-point temperature and, responsive to a determination that the second predicted temperature is not less than the set-point temperature, the controller operates the HVAC system for the first runtime.

Abstract: Systems and methods are disclosed that involve detecting a flammable refrigerant associated with a heating, ventilating, and air conditioning (HVAC) system. In one instance a damper covers an access port allowing a single sensor to monitor at least two separate spaces. In another instance, a multi-probe sensor allows a single sensor to monitor at least two separate spaces.

Abstract: An air conditioner includes a heat exchanger having one or more flow paths. At least one of the flow paths is associated with more than one pass and/or fluid flow through the flow path is restricted. A setting of the beat exchanger includes associations between flow path(s) and/or pass(es). A setting for the heat exchanger is determined and the heat exchanger is allowed to operate in the determined setting.

Abstract: An apparatus for reducing discharge pressure includes a compensator reservoir and a compensator line. The compensator line connects the compensator reservoir and a liquid line. The liquid line connects an outdoor heat exchanger and an indoor heat exchanger of a reversible HVAC system. The compensator line includes a connection to the compensator reservoir and a connection to the liquid line. A first expansion device is disposed in the liquid line and configured to only act on refrigerant flowing towards the outdoor heat exchanger. A second expansion device disposed in the liquid line and configured to only act on refrigerant flowing towards the indoor heat exchanger. The compensator is operable to receive refrigerant, driven by pressure, from the HVAC system, and further operable to allow refrigerant to flow back into the HVAC system.

Abstract: A refrigerant detector testing system according to aspects of the disclosure includes a metering orifice formed in a suction line that is disposed between an evaporator coil and a compressor, a valve fluidly coupled to the metering orifice, a connecting tube fluidly coupled to the valve on a side opposite the metering orifice, a mixing device having an input orifice fluidly coupled to the connecting tube. In some embodiments, the mixing device includes an air intake disposed proximate the input orifice, a throttling portion downstream of the input orifice and the air intake, the throttling portion having a reduced cross-sectional area, and a diffuser section positioned downstream of the throttling portion, the diffuser section having an output orifice. According to aspects of the disclosure, a refrigerant detector fluidly exposed to the output orifice.

Abstract: In various implementations, a heat pump may include heating operations and defrost operations. The heat pump may monitor cycle time(s) for one or more of the operations. Defrost operation(s) in the heat pump may be automatically adjusted based at least partially on cycle times.

Abstract: In various implementations, a heat exchanger system may include one or more flow paths. At least one of the flow paths may be associated with more than one pass and/or fluid flow through the flow path may be restricted. A setting of the heat exchanger system may include associations between flow path(s) and/or pass(es). A setting for the heat exchanger system may be determined, and the heat exchanger system may be allowed to operate in the determined setting, in some implementations.