Abstract: An apparatus comprises: a case enclosing a space; a power connector, extending through the case, to be connected to an external device; a power switch, retained in the space, and configured to be controlled responsive to commands in a UHF/VHF radio signal received by the power switch; a battery, retained in the space, having battery terminals connected to the power connector such that at least one of the battery terminals is connected to the power connector through the power switch; and an antenna, mounted to the case, to receive, and deliver to the power switch, the UHF/VHF radio signal, wherein the commands include a first command to close the power switch to connect the battery to the external device, and a second command to open the power switch to disconnect the battery from the external device.

Abstract: This disclosure describes a rapid, high throughput, facile testing platform. Amplified DNA and CRISPR/Cas9-bound products are analyzed via a lateral flow assay (LFA), and the assay does not require specialized infrastructure. In some embodiments, the testing platform may be used to detect SARS-CoV-2, including, for example, as a test for COVID-19.

Abstract: A method of determining a life defining quantity of a production component manufactured by an additive manufacturing process. The method includes the step of defining a plurality of components to be manufactured by an additive manufacturing technique. The plurality of components has a first test piece and a first production component. The method further includes manufacturing the components in the same manufacturing batch using an additive manufacturing process and with nominally the same material composition and build parameters. A characteristic mechanical property of the first test piece is then determined. The method further includes determining a value of a life defining quantity of the first production component as a function of the first test piece characteristic mechanical property. The first production component and first test piece are then provided with indicators which associate the first production component with the determined life defining quantity.

Abstract: The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.

Abstract: The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.

Abstract: A method of determining a life defining quantity of a production component manufactured by an additive manufacturing process. The method includes the step of defining a plurality of components to be manufactured by an additive manufacturing technique. The plurality of components has a first test piece and a first production component. The method further includes manufacturing the components in the same manufacturing batch using an additive manufacturing process and with nominally the same material composition and build parameters. A characteristic mechanical property of the first test piece is then determined. The method further includes determining a value of a life defining quantity of the first production component as a function of the first test piece characteristic mechanical property. The first production component and first test piece are then provided with indicators which associate the first production component with the determined life defining quantity.

Abstract: The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.

Abstract: The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.

Abstract: A casting core for use in investment casting having at least one gap between two separate core material parts which define separate adjacent cavities in the finished product, wherein the two core material parts are connected by at least one crossover bridge fixing the position of the two core material parts relative to each other, wherein the crossover bridge has a cross section whose wall contour has at least one convex and at least one concave section.

Abstract: A turbomachine component having an aerofoil, such as a blade or a vane for a gas turbine engine, includes a suction side wall and a pressure side wall bordering an aerofoil cavity, and meeting at a leading edge and a trailing edge. The turbomachine component also includes a circumferentially extending first platform wherefrom the aerofoil extends radially. The first platform includes a first-platform cavity corresponding to a shape of the aerofoil and continuous with the aerofoil cavity. The first-platform cavity has a leading-edge end and a trailing-edge end corresponding to the leading edge and the trailing edge, respectively, of the aerofoil. The first-platform cavity at the trailing-edge end forms a protuberance within the first platform. The turbomachine component may optionally include a second-platform cavity in a circumferentially extending second platform. The second-platform cavity at its trailing-edge end forms an additional protuberance within the second platform.

Abstract: The invention is directed to transcription activator-like effector nuclease (TALEN)-mediated DNA editing of disease-causing mutations in the context of the human genome and human cells to treat patients with compromised genetic disorders.

Abstract: A dangerous level of gas safety monitor for indicating a level of a target gas in an atmosphere comprising: a sol-gel layer comprising a first phosphorescent material, exposed to the atmosphere; a light source enabled to stimulate the phosphorescent material; a detector enabled to detect light emitted by the phosphorescent material; a pressure sensor to determine the pressure of the atmosphere; a processor enabled to determine relative phase shift or time delay between the detected light emitted by the phosphorescent material and the emitted light of the light source, wherein the monitor is configured to provide an output indicative of a dangerous level of the target gas in the atmosphere, the output based on the determined pressure and relative phase shift or time delay.

Abstract: A prism for use in scanning applications such as total internal reflection microscopy in which the prism is translated relative to an incident light beam. A geometry is disclosed which cancels walk of the beam footprint at the base of the prism. Walk of the beam footprint due to irregularities in a largely planar sample surface located at the prism base are cancelled by coupling movement of the incident light beam to movement of the sample in the field of view of an objective lens, for example as part of an autofocus arrangement.

Abstract: A device for detecting lightning currents in a wind turbine comprises an inductive loop (1) for carrying a current representative of a lightning current and a sensitive element, such as a resistance or a piezoelectric element electrically connected to the inductive loop (1). The apparatus further comprises an optical fibre strain sensor mechanically connected to the sensitive element, such that, in use, a lightning current results in expansion of the sensitive element and the optical fibre strain sensor produces an optical signal indicative of the strain on the sensitive element due to the expansion. The device has the advantage that the optical signal from the optical fibre strain sensor can be processed by the same signal processing equipment that processes signals from other strain sensors provided on the wind turbine.

Abstract: There is disclosed a prism for use in scanning applications such as total internal reflection microscopy in which the prism is translated relative to an incident light beam. A geometry is disclosed which cancels walk of the beam footprint at the base of the prism. Walk of the beam footprint due to irregularities in a largely planar sample surface located at the prism base are cancelled by coupling movement of the incident light beam to movement of the sample in the field of view of an objective lens, for example as part of an autofocus arrangement.

Abstract: There is disclosed a prism for use in scanning applications such as total internal reflection microscopy in which the prism is translated relative to an incident light beam. A geometry is disclosed which cancels walk of the beam footprint at the base of the prism. Walk of the beam footprint due to irregularities in a largely planar sample surface located at the prism base are cancelled by coupling movement of the incident light beam to movement of the sample in the field of view of an objective lens, for example as part of an autofocus arrangement.

Abstract: Systems and methods for automatic client management authority assignment are described. In one aspect, it is determined that a network management point has not been configured for a client. Responsive to this, a directory service is requested to automatically assign a site code to the client. The automatically assigned site code identifies the management point through which the client can obtain management service(s).

Abstract: A tray assembly has a tray and a divider assembly removably connected to the tray. The tray has a base, a first side fixedly attached to the base, a second side fixedly attached to the base and the first side, a third side opposite the first side and fixedly attached to the base and the second side, and a fourth side opposite the second side and pivotally connected to the base.

Abstract: The present disclosure relates to mapping, tracking, and distributing policy to client devices. Policy, in particular lists of policy assignments are sent to client devices. A determination is made as to the changes or deltas between policy assignments that have been sent to client devices and policy assignments that must be sent to client devices. Identifying the delta policy assignments avoids the need be sent to client devices. Identifying the delta policy assignments avoids the need to send policy assignments that have not change and do not need to be sent to client devices. A server computer determines applicability of policy assignments to particular client devices, tracks if and when policy assignments have been deleted and allows the client to either receive a partial list of policy assignments that are required to update policy or a full list of policy assignments. Full, partial or not list policy assignment depends when a particular client device was last provided a policy assignment.

Abstract: A method for diagnosing and classifying faults in a system is provided. The method comprises acquiring operational data for at least one of a system, one or more subsystems of the system or one or more components of the one or more subsystems. Then, the method comprises analyzing the operational data using one or more diagnostic models. Each diagnostic model uses the operational data to determine a probability of fault associated with at least one of the one or more components or the one or more subsystems. Finally, the method comprises deriving an overall probability of fault for at least one of the system, the one or more subsystems, or the one or more components using the one or more probabilities of fault determined by the one or more diagnostic models and one or more hierarchical relationships between the subsystems and components of the system.