Patents by Inventor Mark P. Chadwick

Mark P. Chadwick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying a protease inhibitor
    Patent number: 6528252
    Abstract: Methods are disclosed whereby inhibition of proteolytic activity causes an increase in delivery of a transferable label from a viral display package to a target cell. Assaying for the transferable label in the target cell in the presence of a test substance can identify the test substance as a protease inhibitor. Protease inhibitors so identified are used therapeutically, to treat conditions such as cancer, inflammation, rheumatoid arthritis and other autoimmune diseases, and infections, including AIDS, herpes, and hepatitis.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: March 4, 2003
    Assignee: BioFocus Discovery Limited
    Inventors: Mark P. Chadwick, Stephen J. Russell
  • Methods and compositions for identifying a protease
    Patent number: 6506557
    Abstract: Methods are disclosed whereby protease activity is directly linked to replication of viral display packages containing protease-encoding polynucleotides in target cells. The methods can be used, inter alia, to identify proteases, including previously undiscovered proteases or variants of known proteases which may have altered substrate specificity.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: January 14, 2003
    Assignee: BioFocus Discovery Limited
    Inventors: Mark P. Chadwick, Stephen J. Russell
  • Methods for identifying a protease inhibitor
    Publication number: 20020072075
    Abstract: Methods are disclosed whereby inhibition of proteolytic activity causes an increase in delivery of a transferable label from a viral display package to a target cell. Assaying for the transferable label in the target cell in the presence of a test substance can identify the test substance as a protease inhibitor. Protease inhibitors so identified are used therapeutically, to treat conditions such as cancer, inflammation, rheumatoid arthritis and other autoimmune diseases, and infections, including AIDS, herpes, and hepatitis.
    Type: Application
    Filed: February 23, 2001
    Publication date: June 13, 2002
    Inventors: Mark P. Chadwick, Stephen J. Russell
  • Methods and compositions for identifying a polynucleotide encoding a protease
    Patent number: 6387686
    Abstract: Methods are disclosed whereby protease activity is directly linked to delivery of a transferable label to a target cell which expresses a protease, via fusion of viral display packages comprising the transferable label with the target cell. The methods can be used, inter alia, to identify proteases, including previously undiscovered proteases or variants of known proteases which may have altered substrate specificity.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: May 14, 2002
    Assignee: BioFocus Discovery Limited
    Inventors: Mark P. Chadwick, Stephen J. Russell, Christian Buchholz
  • Methods & compositions for identifying a protease
    Publication number: 20020039729
    Abstract: Method are disclosed whereby protease activity is directly linked to replication of viral display packages containing protease-encoding polynucleotides in target cells.
    Type: Application
    Filed: February 23, 2001
    Publication date: April 4, 2002
    Inventors: Mark P. Chadwick, Stephen J. Russell
  • Methods and compositions for identifying a polynucleotide encoding a protease
    Publication number: 20020009715
    Abstract: Methods are disclosed whereby protease activity is directly linked to delivery of a transferable label to a target cell which expresses a protease, via fusion of viral display packages comprising the transferable label with the target cell. The methods can be used, inter alia, to identify proteases, including previously undiscovered proteases or variants of known proteases which may have altered substrate specificity.
    Type: Application
    Filed: February 23, 2001
    Publication date: January 24, 2002
    Inventors: Mark P. Chadwick, Stephen J. Russell, Christian Buchholz