Patents by Inventor Mark P. O'Connell

Mark P. O'Connell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substitutional variants of APO-2 ligand
    Patent number: 6740739
    Abstract: A novel cytokine, designated Apo-2 ligand, which induces mammalian cancer cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: May 25, 2004
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Robert F. Kelley, Mark P. O'Connell, Robert M. Pitti, Ralph A. Schwall