Patents by Inventor Mark P. Wentland

Mark P. Wentland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-HYDROXYBENZOMORPHANS
    Publication number: 20240092740
    Abstract: 4-Hydroxybenzomorphans containing carboxamide or thiocarboxamide at the 3-position are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
    Type: Application
    Filed: April 17, 2023
    Publication date: March 21, 2024
    Applicant: Rensselaer Polytechnic Institute
    Inventor: Mark P. WENTLAND
  • 8-carboxamido-2,6-methano-3-benzazocines
    Patent number: 9932349
    Abstract: 8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH2—OH, —CH2NH2, —NHSO2CH3, and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. 8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: April 3, 2018
    Assignee: Rensselaer Polytechnic Institute
    Inventor: Mark P. Wentland
  • 8-CARBOXAMIDO-2,6-METHANO-3-BENZAZOCINES
    Publication number: 20170217977
    Abstract: 8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH2—OH, —CH2NH2, —NHSO2CH3, and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. 8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.
    Type: Application
    Filed: September 9, 2016
    Publication date: August 3, 2017
    Applicant: Rensselaer Polytechnic Institute
    Inventor: Mark P. WENTLAND
  • QUATERNARY OPIOID CARBOXAMIDES
    Publication number: 20170095469
    Abstract: Compounds of formulas: are disclosed. The compounds are useful for ameliorating the side effects of therapeutic opiates.
    Type: Application
    Filed: May 9, 2016
    Publication date: April 6, 2017
    Applicant: Rensselaer Polytechnic Institute
    Inventor: Mark P. WENTLAND
  • LARGE SUBSTITUTENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF
    Publication number: 20160257677
    Abstract: 8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
    Type: Application
    Filed: October 8, 2015
    Publication date: September 8, 2016
    Applicant: Rensselaer Polytechnic Institute
    Inventor: Mark P. WENTLAND
  • Carboxamide bioisosteres of opiates
    Patent number: 9422301
    Abstract: A compound of formula I is disclosed. Compounds of formula I are useful as analgesics, anti-inflammatory agents, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: August 23, 2016
    Assignee: RENSSELAER POLYTECHNIC INSTITUTE
    Inventor: Mark P. Wentland
  • CDKI pathway inhibitors and uses thereof
    Patent number: 9409873
    Abstract: The invention relates to the compounds and methods for inhibiting the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates to compounds and methods for inhibiting the CDKI pathway for studies of and intervention in senescence-related and other CDKI-related diseases.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: August 9, 2016
    Assignee: SENEX BIOTECHNOLOGY INC.
    Inventors: Donald C Porter, Igor B Roninson, Mark P Wentland
  • CDK8-CDK19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer
    Patent number: 9321737
    Abstract: The invention relates to the compounds and methods for inhibiting the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates to compounds and methods for inhibiting the CDKI pathway for studies of and intervention in senescence-related and other CDKI-related diseases. The invention provides new compounds having improved solubility and/or potency, and methods for their use. In various aspects, the invention relates to the treatment of cancer. The invention provides methods for chemoprevention and prevention of tumor recurrence or metastasis. The invention further provides diagnostic techniques for treatment for certain cancer types. The invention utilizes specific inhibitors of CDK8/19 and/or measurement of CDK8 levels in a patient.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: April 26, 2016
    Assignee: SENEX BIOTECHNOLOGY INC
    Inventors: Igor B Roninson, Donald C Porter, Mark P Wentland
  • 4-HYDROXYBENZOMORPHANS
    Publication number: 20160075658
    Abstract: 4-Hydroxybenzomorphans containing carboxamide or thiocarboxamide at the 3-position are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
    Type: Application
    Filed: April 27, 2015
    Publication date: March 17, 2016
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventor: Mark P. WENTLAND
  • Large substituent, non-phenolic opioids and methods of use thereof
    Patent number: 9156821
    Abstract: 8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: October 13, 2015
    Assignee: RENSSELAER POLYTECHNIC INSTITUTE
    Inventor: Mark P. Wentland
  • CARBOXAMIDE BIOISOSTERES OF OPIATES
    Publication number: 20150119416
    Abstract: A compound of formula I is disclosed. Compounds of formula I are useful as analgesics, anti-inflammatory agents, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
    Type: Application
    Filed: January 5, 2015
    Publication date: April 30, 2015
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventor: Mark P. WENTLAND
  • LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF
    Publication number: 20150051194
    Abstract: 8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
    Type: Application
    Filed: October 31, 2014
    Publication date: February 19, 2015
    Applicant: RENSSELAER POLYTECHNIC INSTITUTE
    Inventor: Mark P. WENTLAND
  • Carboxamide bioisosteres of opiates
    Patent number: 8957085
    Abstract: A compound of formula I is disclosed. Compounds of formula I are useful as analgesics, anti-inflammatory agents, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: February 17, 2015
    Assignee: Rensselaer Polytechnic Institute
    Inventor: Mark P. Wentland
  • 4-HYDROXYBENZOMORPHANS
    Publication number: 20150011768
    Abstract: 4-Hydroxybenzomorphans containing carboxamide or thiocarboxamide at the 3-position are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
    Type: Application
    Filed: July 2, 2014
    Publication date: January 8, 2015
    Applicant: Rensselaer Polytechnic Institute
    Inventor: Mark P. WENTLAND
  • CDKI PATHWAY INHIBITORS AND USES THEREOF
    Publication number: 20140378683
    Abstract: The invention relates to the compounds and methods for inhibiting the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates to compounds and methods for inhibiting the CDKI pathway for studies of and intervention in senescence-related and other CDKI-related diseases.
    Type: Application
    Filed: June 21, 2013
    Publication date: December 25, 2014
    Inventors: DONALD C. PORTER, Igor B. Roninson, Mark P. Wentland
  • Large substituent, non-phenolic opioids and methods of use thereof
    Patent number: 8901148
    Abstract: 8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: December 2, 2014
    Assignee: Rensselaer Polytechnic Institute
    Inventor: Mark P. Wentland
  • 8-CARBOXAMIDO-2,6-METHANO-3-BENZAZOCINES
    Publication number: 20140275545
    Abstract: 8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH2—OH, —CH2NH2, —NHSO2CH3, and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. 8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.
    Type: Application
    Filed: December 19, 2013
    Publication date: September 18, 2014
    Applicant: Rensselaer Polytechnic Institute
    Inventor: Mark P. WENTLAND
  • 4-hydroxybenzomorphans
    Patent number: 8802655
    Abstract: 4-Hydroxybenzomorphans containing carboxamide or thiocarboxamide at the 3-position are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. A compound of formula is disclosed, as are pharmaceutically acceptable acid addition salts, such as acetic, benzenesulfonic (besylate), benzoic, camphorsulfonic, citric, ethenesulfonic, fumaric, gluconic, glutamic, hydrobromic, hydrochloric, isethionic, lactic, maleic, malic, mandelic, methanesulfonic, mucic, nitric, pamoic, pantothenic, phosphoric, succinic, sulfuric, tartaric acid or p-toluenesulfonic acid salts. These compounds are useful for the treatment of pain.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: August 12, 2014
    Assignee: Rensselaer Polytechnic Institute
    Inventor: Mark P. Wentland
  • CARBOXAMIDE BIOISOSTERES OF OPIATES
    Publication number: 20140194457
    Abstract: A compound of formula I is disclosed. Compounds of formula I are useful as analgesics, anti-inflammatory agents, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
    Type: Application
    Filed: March 12, 2014
    Publication date: July 10, 2014
    Applicant: Rensselaer Polytechnic Institute
    Inventor: Mark P. WENTLAND
  • 4-HYDROXYBENZOMORPHANS
    Publication number: 20140148475
    Abstract: 4-Hydroxybenzomorphans containing carboxamide or thiocarboxamide at the 3-position are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. A compound of formula is disclosed, as are pharmaceutically acceptable acid addition salts, such as acetic, benzenesulfonic (besylate), benzoic, camphorsulfonic, citric, ethenesulfonic, fumaric, gluconic, glutamic, hydrobromic, hydrochloric, isethionic, lactic, maleic, malic, mandelic, methanesulfonic, mucic, nitric, pamoic, pantothenic, phosphoric, succinic, sulfuric, tartaric acid or p-toluenesulfonic acid salts. These compounds are useful for the treatment of pain.
    Type: Application
    Filed: January 31, 2014
    Publication date: May 29, 2014
    Applicant: Rensselaer Polytechnic Institute
    Inventor: Mark P. WENTLAND