Abstract: The present disclosure provides a compound of formula (I), or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the disclosure, and its therapeutic uses. The present disclosure further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: A method for reducing temporal noise in an image sequence by a camera of an assistance system of a motor vehicle by an electronic computing device. The method includes capturing a first image and a second image of the image sequence of an environment of the motor vehicle by the camera at a first point and a second point in time. Furthermore, determining at least one feature in the second image and determining of pixels associated with the at least one feature in the second image by the feature capturing module. Moreover, generating a weighting map comprising a weight value for each pixel of the second image by an adaptive motion estimation module. Lastly, reducing the temporal noise by blending pixels of the first image with pixels of the second image in dependence on the generated weighting map by a blending module.

Abstract: In a general aspect, a carbon dioxide removal system is presented. In some cases, a gas-liquid contactor is wetted with an alkaline capture solution. A first flow from a first gaseous feed including CO2 from a first source is directed to interact with the alkaline capture solution in the gas-liquid contactor, which forms a first CO2-rich alkaline capture solution. A second flow from a second gaseous feed including CO2 from a second, distinct source is directed to interact with the first CO2-rich alkaline capture solution, which forms a second CO2-rich alkaline capture solution. In some cases, the second flow is independent of the first gaseous feed, and a concentration of CO2 in the second CO2-rich alkaline capture solution is higher than a concentration of CO2 in the first CO2-rich alkaline capture solution. CO2 can be separated from the second CO2-rich alkaline capture solution.

Abstract: A computer device implemented method includes displaying, via the computer device, content on a display device, sensing a pupil size of a user of the computer, and adjusting a luminosity setting of the display device based on the sensed pupil size and a pupil size setpoint.

Abstract: A polyalkyleneoxy polyol (P) has an average nominal functionality in the range of 2 to 8; a hydroxy number in the range of 10 to 500 mg KOH/g measured according to ASTM method D4272; and a weight average molecular weight in the range of 500 to 25,000 measured using GPC with polystyrene standard and tetrahydrofuran as solvent. The polyol (P) contains ethyleneoxy in an amount in the range of 50 to 95 wt. %, based on the overall weight of the polyol (P).

Abstract: The present disclosure provides a method and system by which a precise amount of a viscous fluid sealing compound can be dispensed at required locations through computer vision-based observation of the fluid deposited, its rate and amount of deposition and location; and that the dispensed fluid may be accurately shaped through robotic or other special purpose mechanism motion. The invention enables instant quality inspection of the dispensing process in terms of the locations, amounts and shapes of newly created seals.

Abstract: A portion of a vertical structure is determined for inspection by an unmanned aerial vehicle. A flight plan including safe locations around the vertical structure is determined. Each of the safe locations is associated with a respective column of waypoints. The unmanned aerial vehicle navigates according to the flight plan by navigating to a first safe location of the safe locations, navigating vertically along a first column associated with the first safe location, activating sensors to obtain respective sensor information at at least some of the waypoints associated with the first safe location, navigating to a second safe location of the safe locations, navigating vertically along a second column associated with the second safe location, and activating the sensors to obtain respective sensor information at at least some of the waypoints associated with the second safe location.

Abstract: An apparatus includes a captured carbon dioxide input. The captured carbon dioxide input is coupled to receive captured carbon dioxide from a direct air capture system. The apparatus uses the captured carbon dioxide as a low global warming refrigerant to provide cooling functionality in automotive, commercial, and industrial applications, or other operations involving low global warming refrigerants. In various embodiments, the apparatus is a refrigeration apparatus or a heat pump apparatus. Low global warming carbon dioxide refrigerant is natural, non-toxic, non-flammable, and abundant when obtained from a direct air capture system. Moreover, carbon dioxide refrigerant has a high heat transfer coefficient and has a global warming potential (GWP) of one. Carbon dioxide refrigerant is a more sustainable and efficient coolant option than common refrigerants, such as R22, R152, R404a, and R1234yf refrigerants.

Abstract: One embodiment provides a method, including: receiving, at an information handling device, a command from a user to load an application; determining, using a processor, whether a forecasted loading time for the application exceeds a loading tolerance threshold associated with the user; and providing, responsive to determining that the forecasted loading time exceeds the loading tolerance threshold, a reduced view of the application during a time period that the application is loading. Other aspects are described and claimed.

Abstract: The present invention provides a method of making an enantiomerically enriched tertiary or quaternary ammonium salt, and the use of a non-racemic chiral compound in the synthesis of an enantiomerically enriched tertiary or quaternary ammonium salt. The control of nitrogen-based chirality, achieved via the method of the invention, is useful where a specific tertiary or quaternary ammonium enantiomer is preferred over the other enantiomer, for example where a specific tertiary or quaternary ammonium enantiomer is more effective than the other enantiomer in treating a specific medical condition.

Abstract: A method of assembling a fan wheel includes forming a first wheel portion including a first plurality of impeller blades and a first connector, forming a second wheel portion including a second plurality of impeller blades and a second connector, affixing an end of each of the first plurality of impeller blades to a first surface of a support ring such that the first connector is affixed to the second connector, and affixing an end of each of the second plurality of impeller blades to a second surface of a support ring.

Abstract: A computer implemented method includes establishing a wireless communication order session between a communication device associated with a vehicle and an establishment communication system in response to the vehicle being within an ordering area, receiving transaction information indicative of a transaction transmitted from the communication device associated with the vehicle, and associating the transaction with the vehicle.

Abstract: Disclosed is a method for producing one or more cylinder oils of varying kinematic viscosity for a marine reciprocating internal combustion engine. The method comprises providing a first fluid having a first kinematic viscosity and a first BN, providing a second fluid having a second kinematic viscosity and a second BN, the second kinematic viscosity different from the first kinematic viscosity, and blending the first fluid and the second fluid in a first ratio to produce a first cylinder oil having a kinematic viscosity equal to or less than 14 mm2/s at 100° C.

Abstract: Provided herein are compounds and compositions that inhibit telomerase and/or the TERT gene with a mutant promoter. Further provided are small molecule compounds or compositions having beneficial effects in cancer treatment. Methods of making the compounds and compositions and methods of using the compounds and compositions, such as using the compounds and compositions to treat cancer, are also provided.

Abstract: The present disclosure relates to compounds according to Formula I (I) or a pharmaceutically acceptable salt and/or solvate thereof, as well as compositions including such compounds and uses thereof, where R1 is an unsubstituted C1-C12 alkyl; and R2, R3, and R4 are each independently H or —C(O)—(unsubstituted C1-C12 alkyl). Among other things, the present disclosure evidences that the significant upregulation of CD20 by the inhibition of a-mannosidase enzymes by compounds of the present technology potentiates the activity of anti-CD20 mAbs and importantly sensitize cell lines that are resistant to the action of these antibodies.

Abstract: Methods, systems and apparatus, for an unmanned aerial vehicle electromagnetic avoidance and utilization system. One of the methods includes obtaining a flight package indicating a flight pattern associated with inspecting a structure, the flight pattern causing the UAV to remain at a standoff distance from the structure, wherein the standoff distance is based on an electromagnetic field associated with the structure, and wherein the flight pattern is laterally constrained according to a property geofence associated with a right of way of the structure. The UAV is navigated according to the flight pattern, and the UAV captures images of the structure. For an initial portion of the flight pattern, the UAV navigates at an altitude based on the standoff distance and the property geofence towards the structure. The UAV determines a location at which to capture images of the structure, and the UAV provides the captured images to a user device.

Abstract: A method comprising providing a first fluid, second fluid, and third fluid having a first kinematic viscosity and a first BN, a second kinematic viscosity and a second BN, and a third kinematic viscosity and a third BN respectively, obtaining data identifying (i) a target kinematic viscosity of a cylinder oil to be produced, (ii) a target BN of the cylinder oil to be produced, and (iii) the kinematic viscosity and the BN of each of the first, second, and third fluids. Based on at least the identified kinematic viscosity and BN, the method comprises determining a ratio of first, second, and third fluid to produce a cylinder oil having a kinematic viscosity corresponding to the target kinematic viscosity and/or a BN corresponding to the target BN, and blending the first, second, and third fluids in the determined ratio to produce the cylinder oil.

Abstract: Hyperlinked icons, images, and emoji may be shared by users in a real-time messaging environment, such as text messaging. A user may send a message including a clickable emoji to a receiving user, where the received clickable emoji is displayed in the message. If the received clickable emoji is selected by the receiving user, web content linked to the emoji is retrieved and displayed. Messaging server(s) monitor messages, events, and social trends collecting contextual data. Content providers use collected contextual data to efficiently deliver targeted content.

Abstract: An efficient low-energy carbon dioxide removal system comprises an automated air mover equipped with sensing devices to measure flow rate, volume, level, pressure, temperature and concentration. Packing materials and air-liquid distributors are used in a multi-stage catalytic reactor. The multi-stage catalytic reactor processes ambient air and generates pure carbon dioxide gas and generates exhausted gas released to ambient air. In operation, air contacts the base solution in the presence of a catalyst via the air mover, distributor, and packing materials. The air reacts with the base solution thereby generating a base solution having carbon dioxide and generating exhaust (absorption reaction). Next, the exhaust is released from the reactor. Next, a catalyst is added, heat is applied to the base solution having carbon dioxide thereby generating carbon dioxide and generating a base solution without carbon dioxide (desorption reaction).

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for an unmanned aerial system inspection system. One of the methods is performed by a UAV and includes obtaining, from a user device, flight operation information describing an inspection of a vertical structure to be performed, the flight operation information including locations of one or more safe locations for vertical inspection. A location of the UAV is determined to correspond to a first safe location for vertical inspection. A first inspection of the structure is performed is performed at the first safe location, the first inspection including activating cameras. A second safe location is traveled to, and a second inspection of the structure is performed. Information associated with the inspection is provided to the user device.