Patents by Inventor Mark Paulik

Mark Paulik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250034225
    Abstract: This invention relates to isolated polypeptides that are long acting analogs of human GLP-1. The disclosed GLP-1 receptor agonist polypeptides have beneficial physicochemical properties relative to endogenous GLP-1 and known synthetic GLP-1 receptor agonist polypeptides, such as longer (i.e., “long-acting”) elimination half-lives (t1/2), and improved solubility and thermal stability. This invention also relates to methods of using presently disclosed GLP-1 receptor agonist polypeptides in a variety of therapeutic indications, as well as methods of producing the same. The disclosed GLP-1 receptor agonist polypeptides are particularly useful in methods of treating metabolic diseases or disorders, such as type 2 diabetes, treating obesity, and providing weight loss, and in methods of treating nonalcoholic fatty liver disease (NAFLD) and/or nonalcoholic steatohepatitis (NASH).
    Type: Application
    Filed: July 22, 2024
    Publication date: January 30, 2025
    Inventors: William Blackwell, Ved P. Srivastava, Mark Paulik
  • Patent number: 12084485
    Abstract: This invention relates to isolated polypeptides that are long acting analogs of human GLP-1. The disclosed GLP-1 receptor agonist polypeptides have beneficial physicochemical properties relative to endogenous GLP-1 and known synthetic GLP-1 receptor agonist polypeptides, such as longer (i.e., “long-acting”) elimination half-lives (t1/2), and improved solubility and thermal stability. This invention also relates to methods of using presently disclosed GLP-1 receptor agonist polypeptides in a variety of therapeutic indications, as well as methods of producing the same. The disclosed GLP-1 receptor agonist polypeptides are particularly useful in methods of treating metabolic diseases or disorders, such as type 2 diabetes, treating obesity, and providing weight loss, and in methods of treating nonalcoholic fatty liver disease (NAFLD) and/or nonalcoholic steatohepatitis (NASH).
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: September 10, 2024
    Assignee: I2O Therapeutics, Inc.
    Inventors: William Blackwell, Ved P. Srivastava, Mark Paulik
  • Publication number: 20230063420
    Abstract: This invention relates to isolated polypeptides that are long acting analogs of human GLP-1. The disclosed GLP-1 receptor agonist polypeptides have beneficial physicochemical properties relative to endogenous GLP-1 and known synthetic GLP-1 receptor agonist polypeptides, such as longer (i.e., “long-acting”) elimination half-lives (t1/2), and improved solubility and thermal stability. This invention also relates to methods of using presently disclosed GLP-1 receptor agonist polypeptides in a variety of therapeutic indications, as well as methods of producing the same. The disclosed GLP-1 receptor agonist polypeptides are particularly useful in methods of treating metabolic diseases or disorders, such as type 2 diabetes, treating obesity, and providing weight loss, and in methods of treating nonalcoholic fatty liver disease (NAFLD) and/or nonalcoholic steatohepatitis (NASH).
    Type: Application
    Filed: December 16, 2021
    Publication date: March 2, 2023
    Inventors: William Blackwell, Ved P. Srivastava, Mark Paulik
  • Publication number: 20050066978
    Abstract: The present invention relates, in general, to thermography and, in particular, to a method of using infrared thermography to monitor physiological and molecular events that elicit a thermogenic response in animals (including humans), plants, tissues, cells and cell-free systems. The present method can be used for screening, identifying, and ranking drug candidates for multiple diseases, disorders and conditions.
    Type: Application
    Filed: August 30, 2004
    Publication date: March 31, 2005
    Inventors: James Lenhard, Mark Paulik
  • Patent number: D773531
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: December 6, 2016
    Assignee: Gamblit Gaming, LLC
    Inventors: Edvard Toth, Timothy Isaacson, Zachary Foley, Mark Paulik, Michael Splitz
  • Patent number: D776150
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: January 10, 2017
    Assignee: Gamblit Gaming, LLC
    Inventor: Mark Paulik
  • Patent number: D779544
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: February 21, 2017
    Assignee: Gamblit Gaming, LLC
    Inventor: Mark Paulik
  • Patent number: D781340
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: March 14, 2017
    Assignee: Gamblit Gaming, LLC
    Inventors: Edvard Toth, Mark Paulik, Brian Erice, Zach Foley
  • Patent number: D801376
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: October 31, 2017
    Assignee: Gamblit Gaming, LLC
    Inventor: Mark Paulik
  • Patent number: D823888
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: July 24, 2018
    Assignee: Gamblit Gaming, LLC
    Inventors: Edvard Toth, Timothy Isaacson, Zachary Foley, Mark Paulik, Michael Splitz
  • Patent number: D849771
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: May 28, 2019
    Assignee: Gamblit Gaming, LLC
    Inventors: Zachary Foley, Mark Paulik, Edvard Toth
  • Patent number: D849772
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: May 28, 2019
    Assignee: Gamblit Gaming, LLC
    Inventors: Edvard Toth, Mark Paulik, Brian Erice
  • Patent number: D851662
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: June 18, 2019
    Assignee: Gamblit Gaming, LLC
    Inventors: Edvard Toth, Mark Paulik, Brian Erice, Zachary Foley
  • Patent number: D852810
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: July 2, 2019
    Assignee: Gamblit Gaming, LLC
    Inventors: Edvard Toth, Zachary Foley, Mark Paulik, Brian Erice
  • Patent number: D854554
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: July 23, 2019
    Assignee: Gamblit Gaming, LLC
    Inventors: Edvard Toth, Zachary Foley, Mark Paulik, Brian Erice
  • Patent number: D860240
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: September 17, 2019
    Assignee: gamblit Gaming, LLC
    Inventor: Mark Paulik
  • Patent number: D868825
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: December 3, 2019
    Assignee: Gamblit Gaming, LLC
    Inventors: Mark Paulik, Edvard Toth