Patents by Inventor Mark Pausch

Mark Pausch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080040819
    Abstract: Methods of identifying agents for treatment of schizophrenia and related disorders.
    Type: Application
    Filed: August 14, 2007
    Publication date: February 14, 2008
    Applicant: Wyeth
    Inventors: Brian BATES, Sheree Logue, Mark Pausch
  • Publication number: 20080039535
    Abstract: Methods of identifying agents for treatment of schizophrenia and related disorders.
    Type: Application
    Filed: August 14, 2007
    Publication date: February 14, 2008
    Applicant: Wyeth
    Inventors: Brian Bates, Sheree Logue, Mark Pausch
  • Publication number: 20080032317
    Abstract: This invention relates to mutant G protein-coupled receptors with improved G-protein coupling and receptor response, yeast cells expressing such receptors, vectors useful for making such cells, and methods of making and using same.
    Type: Application
    Filed: February 21, 2007
    Publication date: February 7, 2008
    Inventors: Mark Pausch, Jurgen Wess
  • Publication number: 20060294614
    Abstract: The present invention particularly relates to a newly identified murine genomic polynucleotide that encodes an ortholog of the human P2T receptor which is expressed at high levels in the central nervous system, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. The invention relates also to identifying compounds which may be agonists, antagonists and/or inhibitors of P2T, and therefore potentially useful in therapy.
    Type: Application
    Filed: August 14, 2006
    Publication date: December 28, 2006
    Applicant: Wyeth
    Inventor: Mark Pausch
  • Publication number: 20060110792
    Abstract: This invention relates generally to a new family of potassium channels. More particularly, the present invention relates to the cloning and characterization of a family of distinct trans-membrane potassium ion channels, characterization of such channels, newly identified polynucleotide sequences, polypeptides encoded by such sequences, expression vectors capable of heterologous expression of such polynucleotide sequences, transformed host cells containing the expression vectors, and assay methods and kits therefor for determining the expression of heterologous nucleotide sequences encoding all or a portion of said potassium channels in host cells, chromosome mapping, diagnostic methodologies and kits therefore. Genes encoding potassium channels representative of this family were cloned from Drosophila melanogaster, Caenorhabditis elegans, human and mouse ESTs, and human brain, heart and kidney cDNA libraries.
    Type: Application
    Filed: July 12, 2005
    Publication date: May 25, 2006
    Inventors: Mark Pausch, Laura Price
  • Publication number: 20060075510
    Abstract: The present invention particularly relates to a newly identified murine genomic polynucleotide that encodes an ortholog of the human P2T receptor which is expressed at high levels in the central nervous system, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. The invention relates also to identifying compounds which may be agonists, antagonists and/or inhibitors of P2T, and therefore potentially useful in therapy.
    Type: Application
    Filed: July 30, 2002
    Publication date: April 6, 2006
    Applicant: Wyeth
    Inventor: Mark Pausch
  • Publication number: 20060008831
    Abstract: The invention provides methods and systems for predicting or evaluating protein-ligand coupling specificities. A pattern recognition model can be trained by selected sequence segments of training proteins which have a specified ligand coupling specificity. Each selected sequence segment is believed to include amino acid residue(s) that may contribute to the ligand coupling specificity of the corresponding training protein. Sequence segments in a protein of interest can be similarly selected and used to query the trained model to determine if the protein of interest has the same ligand coupling specificity as the training proteins. In one embodiment, the pattern recognition model employed is a hidden Markov model which is trained by concatenated cytosolic domains of GPCRs which have interaction preference to a specified class of G proteins. This trained model can be used to evaluate G protein coupling specificity of orphan GPCRs.
    Type: Application
    Filed: July 8, 2005
    Publication date: January 12, 2006
    Inventors: Kodangattil Sreekumar, Youping Huang, Mark Pausch, Kamalakar Gulukota
  • Publication number: 20050032165
    Abstract: This invention relates generally to a new family of potassium channels, whose molecular architecture is characterized by four membrane spanning domains and two putative pore forming domains. More particularly, the present invention relates to the cloning and characterization of mutants of this family of distinct trans-membrane potassium ion channels which confer improved inward potassium flux under acidic conditions, characterization of such channels, newly identified polynucleotide sequences, polypeptides encoded by such sequences, expression vectors capable of heterologous expression of such polynucleotide sequences, transformed host cells containing the expression vectors, and assay methods and kits therefor for determining the expression of heterologous nucleotide sequences encoding all or a portion of said potassium channels in host cells, chromosome mapping, diagnostic methodologies and kits therefore.
    Type: Application
    Filed: June 18, 2004
    Publication date: February 10, 2005
    Inventor: Mark Pausch