Abstract: Kits and methods of using the kits for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding are disclosed. The sample analysis kits employ nucleic acid encoding and/or nucleic acid recording of a molecular interaction and/or reaction, such as recognition events (e.g., between an antigen and an antibody, between a modified terminal amino acid residue, or between a small molecule or peptide therapeutic and a target, etc.). Additional barcoding reagents, such as those for cycle-specific barcoding (e.g., “clocking”), compartment barcoding, combinatorial barcoding, spatial barcoding, or any combination thereof, may be included in the kits. The sample may comprise macromolecules, including peptides, polypeptides, and proteins, and the recording may generate molecular interaction and/or reaction information, and/or polypeptide sequence information.

Abstract: Devices, systems, and methods are provided for registering image data with robotic data for image-guided robotic catheters and other elongate bodies. Fluid drive systems can be used to provide robotically coordinated motion. Precise control over catheter-supported tools is enhanced by alignment of fluoroscopic and ultrasound image data, particularly for structural heart and other therapies in which the catheter will interact with soft tissues. A marker plate having a planar array of machine-readable 2D barcode markers may facilitate alignment of image and robotic data. Determining an ultrasound-based pose of a component in the ultrasound image field allows that component to effectively a fiducial for alignment.

Abstract: Methods, apparatuses, and systems for diagnosing misalignment in gas detecting devices are provided. An example method may include causing at least one detector component of a receiver element of the open path gas detecting device to generate a first light intensity indication corresponding to first infrared light; causing the at least one detector component to generate a second light intensity indication corresponding to second infrared light; and generating an alignment indication based at least in part on the first light intensity indication and the second light intensity indication.

Abstract: A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.

Abstract: Kits and methods of using the kits for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding are disclosed. The sample analysis kits employ nucleic acid encoding and/or nucleic acid recording of a molecular interaction and/or reaction, such as recognition events (e.g., between an antigen and an antibody, between a modified terminal amino acid residue, or between a small molecule or peptide therapeutic and a target, etc.). Additional barcoding reagents, such as those for cycle-specific barcoding (e.g., “clocking”), compartment barcoding, combinatorial barcoding, spatial barcoding, or any combination thereof, may be included in the kits. The sample may comprise macromolecules, including peptides, polypeptides, and proteins, and the recording may generate molecular interaction and/or reaction information, and/or polypeptide sequence information.

Abstract: Methods and Kits for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding are disclosed. The sample analysis kits employ nucleic acid encoding and/or nucleic acid recording of a molecular interaction and/or reaction, such as recognition events (e.g., between an antigen and an antibody, between a modified terminal amino acid residue, or between a small molecule or peptide therapeutic and a target, etc.). Assays that do not require the cyclic transfer of information between a coding tag and a recording tag are also disclosed, including single cycle assays.

Abstract: An air sampling device and method of sampling air. The device has a housing body and a retaining assembly for a sampling device. A plenum has a top end coupled to the housing body about an opening such that the plenum is in flow communication with the opening and receives air flow generally from the top end to the bottom end generally along the longitudinal length thereof. A flow connection is coupled to the bottom end of the plenum. A mass flow meter has an input coupled to the flow connection and is in flow communication with the plenum via the flow connection. A blower is configured to draw air past the sampling device, through the opening, and through the plenum, such that a measuring portion of the air flows through the flow connection and through the mass flow meter, which measured the flow rate of the measuring portion.

Abstract: A micromobility vehicle for use in a vehicle share system includes a frame, a footboard fixed to the frame, a seat fixed to the frame, handlebars, and a computing device. The frame includes a horizontal portion and an angled portion. The seat is separated from the footboard in a vertical direction by a fixed distance. The handlebars are separated from the footboard in the vertical direction by a fixed distance. A cargo storage location is at least partially disposed between the seat and the footboard. The computing device is fixed to the frame and capable of executing a transportation matching system application.

Abstract: An apparatus for use in manufacturing a component of an implantable medical device comprises a fixture comprising a first fixture member having a plurality of semi-circular recesses in a lower surface thereof, and a second fixture member having a plurality of semi-circular recesses in an upper surface thereof, the first and second fixture members being configured to be selectively fastened together via a plurality of fasteners, wherein in an assembled state of the fixture, each of the semi-circular recesses of the first fixture member lower surface is aligned with an opposing semi-circular recess in the second fixture member upper surface to define a plurality of workpiece openings each dimensioned to receive and secure a respective work piece to be machined to the fixture.

Abstract: A stent delivery system includes an outer shaft and an inner shaft extending at least partially within a lumen of the outer shaft. The inner shaft includes a stent receiving region, and a distal tip coupled to a distal end of the inner shaft. The distal tip includes a plurality of hooks positioned adjacent a proximal edge of the distal tip. A stent is disposed along the stent receiving region, and includes a first end region, a second end region, and one or more tethers coupled to the first end region of the stent. The one or more tethers are configured to engage with the plurality of hooks, thereby coupling the stent and the distal tip. The one of the one or more tethers may be configured to be actuated by a user to move the stent between a first, pre-deployed configuration and a second, deployed configuration.

Abstract: In various embodiments, provided are immune response signatures that can be used for the diagnosis, monitoring, and treatment of long-term diseases and inflammatory disorders caused by viral infections. In some embodiments, the viral infection is SARS-CoV-2 infection. In some embodiments, the long-term disease is post-acute sequelae of SARS-CoV-2 infection (PASC).

Abstract: Stents and/or endoluminal implants for extending across two non-adherent structures/tissues. An illustrative stent may comprise an elongated tubular body having a scaffolding forming a plurality of cells and a coating disposed over an outer surface of the elongated tubular body. The coating may comprise a first micro-porous layer and a macro-porous layer including a plurality of loops disposed over the micro-porous layer.

Abstract: An apposition device having a first elongate element movably coupled with a second elongate element. The second elongate element is deployable distal to the structures to be apposed, in a position transverse to the first elongate element. The first elongate element may be pulled to pull the second elongate element to move the structures into apposition. A third element may be positioned proximal to the structures to hold the structures in apposition. The third element may be a ratcheting element fixable in place with respect to the first elongate element. The apposition device may be deployed with a fine gauge needle. The second elongate element may be deployed from a side port in the needle facilitating deployment, and/or movement of the second elongate element with respect to the first elongate element and into a deployment configuration. Such arrangement may allow control of the first elongate element independent of the needle.

Abstract: The present invention provides antibodies or antigen-binding fragment thereof that bind and neutralize TREM1 for use in the treatment of a motor neuron degenerative disorders, in particular amyotrophic lateral sclerosis.

Abstract: A method and system for authoring a three-dimensional (3D) presentation can involve dividing a scene into a grid of equals-sized segments or non-equally sized segments, wherein one or more 360-degree cameras record the scene from a center of each segment, and a size of the each segment is proportional to a complexity of an environment captured in the scene. One or more objects can be created within the scene for a user interaction with a 3D presentation of the scene in the context of a video stream. A logical center of the object(s) can be used as a center point for recording a 360-degree video by the one or more 360-degree cameras for use as a low fidelity background video when the user interacts with the 3D presentation of the scene. The 3D presentation can be based on a 3D model.

Abstract: Systems and methods for treating a stricture, for example along the biliary and/or pancreatic tract, are disclosed. An example system may include a handle having a base having a distal end region and a proximal end region. A length adjustment member may be coupled to the handle. A length actuator may be coupled to the distal end region of the handle. A catheter shaft may be coupled to the handle. A steering mechanism may be coupled to the handle. The steering mechanism may include an elongate steering member having a first end region coupled to the handle, a first body region extending along the catheter shaft, a loop region extending about the catheter shaft, a second body region extending along the catheter shaft, and a second end region coupled to the handle.

Abstract: Aspects of the disclosure relate to processing systems using improved model-based techniques for performing virtual device simulation. A computing platform may receive commands directing the launch of a visual model corresponding to a device identifier. The computing platform may send commands directing a database to provide a state machine model corresponding to the visual model. The computing platform may receive the state machine model and subsequently an indication of a virtual interaction with the visual model. Based on the indication, the computing platform may cause a state change of the visual model and may send, to the client device, state change information corresponding to the visual model. The computing platform may receive information verifying simulated operation parameters, and based on the information the computing platform may cause an implementation update to a device, corresponding to the visual model, based on the simulated operation parameters.

Abstract: An elongate medical device is adapted to provide adjustable flexibility. The elongate medical device includes an inner coil having one or more inner coil filars extending in a first direction, and an outer coil having one or more outer filars extending in a second direction. A hypotube extends proximally from the inner coil and the outer coil. A cable extends through the inner coil and through the hypotube, where a distal end of the cable, a distal end of the inner coil and a distal end of the outer coil are all secured together at a distal end of the elongate medical device, such that applying a tensile force to the cable, relative to the hypotube, causes the inner coil and outer coil in combination to increase in stiffness.

Abstract: An air sampling device and method of sampling air. The device has a housing body and a retaining assembly for a sampling device. A plenum has a top end coupled to the housing body about an opening such that the plenum is in flow communication with the opening and receives air flow generally from the top end to the bottom end generally along the longitudinal length thereof. A flow connection is coupled to the bottom end of the plenum. A mass flow meter has an input coupled to the flow connection and is in flow communication with the plenum via the flow connection. A blower is configured to draw air past the sampling device, through the opening, and through the plenum, such that a measuring portion of the air flows through the flow connection and through the mass flow meter, which measured the flow rate of the measuring portion.

Abstract: The embodiments disclose a method including providing an aerial drone coupled wirelessly to a social distancing application on a user digital device, wherein the drone is coupled to solar cell panels for recharging its batteries, providing a strobe light coupled to the drone for signaling an S.O.S.