Abstract: Kits and methods of using the kits for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding are disclosed. The sample analysis kits employ nucleic acid encoding and/or nucleic acid recording of a molecular interaction and/or reaction, such as recognition events (e.g., between an antigen and an antibody, between a modified terminal amino acid residue, or between a small molecule or peptide therapeutic and a target, etc.). Additional barcoding reagents, such as those for cycle-specific barcoding (e.g., “clocking”), compartment barcoding, combinatorial barcoding, spatial barcoding, or any combination thereof, may be included in the kits. The sample may comprise macromolecules, including peptides, polypeptides, and proteins, and the recording may generate molecular interaction and/or reaction information, and/or polypeptide sequence information.

Abstract: Some methods may involve receiving a first content stream that includes first audio signals, rendering the first audio signals to produce first audio playback signals, generating first calibration signals, generating first modified audio playback signals by inserting the first calibration signals into the first audio playback signals, and causing a loudspeaker system to play back the first modified audio playback signals, to generate first audio device playback sound. The method(s) may involve receiving microphone signals corresponding to at least the first audio device playback sound and to second through Nth audio device playback sound corresponding to second through Nth modified audio playback signals (including second through Nth calibration signals) played back by second through Nth audio devices, extracting second through Nth calibration signals from the microphone signals and estimating at least one acoustic scene metric based, at least partly, on the second through Nth calibration signals.

Abstract: An improved dispenser unit for dispensing bulk food items, including a cabinet having at least one hopper having a drum with product compartments, a deflector and flexible gate valve, a dispense assembly, and a control system. The dispense assembly may or may not include one or more belts and/or sensors. The product compartments include flexible and/or elastic membranes, which dynamically change the effective product storage volume within a compartment, and eliminate rigid or semi-rigid pinch points between the drum and drum compartment. A product flow divider may be positioned above the receiving container in the dispense assembly, said divider configured to cause the dispensed product to divide into two or more flow streams into the receiving container. The receiving container may be vibrated or oscillated.

Abstract: Kits and methods of using the kits for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding are disclosed. The sample analysis kits employ nucleic acid encoding and/or nucleic acid recording of a molecular interaction and/or reaction, such as recognition events (e.g., between an antigen and an antibody, between a modified terminal amino acid residue, or between a small molecule or peptide therapeutic and a target, etc.). Additional barcoding reagents, such as those for cycle-specific barcoding (e.g., “clocking”), compartment barcoding, combinatorial barcoding, spatial barcoding, or any combination thereof, may be included in the kits. The sample may comprise macromolecules, including peptides, polypeptides, and proteins, and the recording may generate molecular interaction and/or reaction information, and/or polypeptide sequence information.

Abstract: Methods and Kits for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding are disclosed. The sample analysis kits employ nucleic acid encoding and/or nucleic acid recording of a molecular interaction and/or reaction, such as recognition events (e.g., between an antigen and an antibody, between a modified terminal amino acid residue, or between a small molecule or peptide therapeutic and a target, etc.). Assays that do not require the cyclic transfer of information between a coding tag and a recording tag are also disclosed, including single cycle assays.

Abstract: A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.

Abstract: Methods, apparatuses, and systems for diagnosing misalignment in gas detecting devices are provided. An example method may include causing at least one detector component of a receiver element of the open path gas detecting device to generate a first light intensity indication corresponding to first infrared light; causing the at least one detector component to generate a second light intensity indication corresponding to second infrared light; and generating an alignment indication based at least in part on the first light intensity indication and the second light intensity indication.

Abstract: A replaceable fluid container for an engine comprising: a reservoir for holding a fluid; a fluid coupling adapted to provide fluidic communication between the reservoir and a fluid circulation system of an engine; and a data provider arranged such that positioning the container to permit fluidic communication between the reservoir and the fluid circulation system of the engine arranges the data provider for data communication with an engine control device of the engine. There is also provided a method of facilitating control of an engine and an engine control system, apparatus and a vehicle.

Abstract: An apparatus for use in manufacturing a component of an implantable medical device comprises a fixture comprising a first fixture member having a plurality of semi-circular recesses in a lower surface thereof, and a second fixture member having a plurality of semi-circular recesses in an upper surface thereof, the first and second fixture members being configured to be selectively fastened together via a plurality of fasteners, wherein in an assembled state of the fixture, each of the semi-circular recesses of the first fixture member lower surface is aligned with an opposing semi-circular recess in the second fixture member upper surface to define a plurality of workpiece openings each dimensioned to receive and secure a respective work piece to be machined to the fixture.

Abstract: A stent delivery system includes an outer shaft and an inner shaft extending at least partially within a lumen of the outer shaft. The inner shaft includes a stent receiving region, and a distal tip coupled to a distal end of the inner shaft. The distal tip includes a plurality of hooks positioned adjacent a proximal edge of the distal tip. A stent is disposed along the stent receiving region, and includes a first end region, a second end region, and one or more tethers coupled to the first end region of the stent. The one or more tethers are configured to engage with the plurality of hooks, thereby coupling the stent and the distal tip. The one of the one or more tethers may be configured to be actuated by a user to move the stent between a first, pre-deployed configuration and a second, deployed configuration.

Abstract: Methods for selectively depositing on metallic surfaces are disclosed. Some embodiments of the disclosure utilize a hydrocarbon having at least two functional groups selected from alkene, alkyne, ketone, hydroxyl, aldehyde, or combinations thereof to form a self-assembled monolayer (SAM) on metallic surfaces.

Abstract: A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.

Abstract: A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.

Abstract: Provided herein are compositions comprising ruboxistaurin free base and its salts thereof and methods of use for treating conditions of the skin.

Abstract: A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.

Abstract: An apparatus and method of rendering audio. A binaural signal is split on an amplitude weighting basis into a front binaural signal and a rear binaural signal, based on perceived position information of the audio. In this manner, the front-back differentiation of the binaural signal is improved.

Abstract: In various embodiments, provided are immune response signatures that can be used for the diagnosis, monitoring, and treatment of long-term diseases and inflammatory disorders caused by viral infections. In some embodiments, the viral infection is SARS-CoV-2 infection. In some embodiments, the long-term disease is post-acute sequelae of SARS-CoV-2 infection (PASC).

Abstract: Stents and/or endoluminal implants for extending across two non-adherent structures/tissues. An illustrative stent may comprise an elongated tubular body having a scaffolding forming a plurality of cells and a coating disposed over an outer surface of the elongated tubular body. The coating may comprise a first micro-porous layer and a macro-porous layer including a plurality of loops disposed over the micro-porous layer.

Abstract: An apposition device having a first elongate element movably coupled with a second elongate element. The second elongate element is deployable distal to the structures to be apposed, in a position transverse to the first elongate element. The first elongate element may be pulled to pull the second elongate element to move the structures into apposition. A third element may be positioned proximal to the structures to hold the structures in apposition. The third element may be a ratcheting element fixable in place with respect to the first elongate element. The apposition device may be deployed with a fine gauge needle. The second elongate element may be deployed from a side port in the needle facilitating deployment, and/or movement of the second elongate element with respect to the first elongate element and into a deployment configuration. Such arrangement may allow control of the first elongate element independent of the needle.

Abstract: The present invention provides antibodies or antigen-binding fragment thereof that bind and neutralize TREM1 for use in the treatment of a motor neuron degenerative disorders, in particular amyotrophic lateral sclerosis.