Patents by Inventor Mark Pimentel

Mark Pimentel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200390742
    Abstract: The present invention relates to, in part, methods and compositions for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS). Particularly, modified-release formulations comprising at least one antimethanogenic statin are provided which release the antimethanogenic statin in the intestines.
    Type: Application
    Filed: June 21, 2017
    Publication date: December 17, 2020
    Applicants: Cedars-Sinai Medical Center, Synthetic Biologics, Inc.
    Inventors: Vincent John Wacher, Mark Pimentel
  • Patent number: 10844417
    Abstract: Disclosed are methods of diagnosing constipation and constipation-predominant irritable bowel syndrome by screening for the presence of abnormally high levels of methane and/or methanogenic organisms in a subject.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: November 24, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Henry C. Lin
  • Publication number: 20200360468
    Abstract: The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.
    Type: Application
    Filed: May 29, 2020
    Publication date: November 19, 2020
    Applicant: Cedars-Sinai Medical Center
    Inventors: Mark PIMENTEL, Ruchi MATHUR, Christopher CHANG
  • Publication number: 20200346032
    Abstract: The disclosed technology relates to a system for delivering UV-A/B light with a catheter to treat infectious or inflammatory disorders in a patient. While UV light in the UV-C range has traditionally been used to treat skin disorders and for focused ablation of plaques in the arteries and other targeted internal uses, it has not been developed for broader infection, inflammation or neoplasia treatment inside the human body. Here, the inventor(s) developed a system for emission of therapeutic doses of UV light via a catheter, capsule, endoscope, tube or port that can be used to manage internal infections and inflammatory conditions inside a patient.
    Type: Application
    Filed: July 15, 2020
    Publication date: November 5, 2020
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Ali Rezaie, Mark Pimentel, Gil Y. Melmed
  • Publication number: 20200323781
    Abstract: The present invention relates to, in part, methods and compositions for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS). Particularly, modified-release formulations comprising at least one antimethanogenic statin are provided which release the antimethanogenic statin in the intestines.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 15, 2020
    Applicants: Cedars-Sinai Medical Center, Synthetic Biologics, Inc.
    Inventors: Mark Pimentel, Ruchi Mathur, Steve Kanzer, Vince Wacher
  • Publication number: 20200284804
    Abstract: Described herein are methods and systems for detecting and/or distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) and celiac disease. The methods and systems can utilize the detection of anti-CdtB antibodies and/or anti-vinculin antibodies to detect IBS, distinguish IBS from IBD and/or celiac disease. Further described are methods for selecting a therapy to treat IBS, IBD or celiac disease.
    Type: Application
    Filed: May 18, 2020
    Publication date: September 10, 2020
    Applicant: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Christopher Chang
  • Publication number: 20200271650
    Abstract: The present invention describes methods for preventing IBS, reducing the likelihood of developing IBS and/or treating IBS by administering CDT inhibitors and/or CDT neutralizers to a subject in need thereof. The present invention also describes methods of eliciting a specific immune response and methods of vaccinating a subject to prevent IBS or to reduce the likelihood of developing or having IBS. The present invention further describes methods of diagnosing IBS by detecting the presence or absence of CDT or a CDT marker in a subject.
    Type: Application
    Filed: January 6, 2020
    Publication date: August 27, 2020
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Mark Pimentel, Christopher Chang
  • Publication number: 20200271665
    Abstract: Described herein are methods and systems for the detection of anti-vinculin antibodies, for determining a presence or likely presence of a gastrointestinal motility disorder, bladder motility disorder, or fibromyalgia. Further provided are methods of selecting and/or administering a therapy based on the presence or absence of anti-vinculin antibodies.
    Type: Application
    Filed: October 7, 2019
    Publication date: August 27, 2020
    Applicant: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Christopher Chang
  • Patent number: 10736871
    Abstract: The present invention relates to, in part, methods for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS) using at least one anti-methanogenic lovastatin analog or derivative. In addition, modified-release formulations comprising at least one anti-methanogenic lovastatin analog or derivative are provided which release the anti-methanogenic lovastatin analog or derivative in the gastrointestinal tract.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: August 11, 2020
    Assignees: Cedars-Sinai Medical Center, Synthetic Biologics, Inc.
    Inventors: Mark Pimentel, Vince Wacher
  • Patent number: 10688149
    Abstract: The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: June 23, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Ruchi Mathur, Christopher Chang
  • Patent number: 10690679
    Abstract: Described herein are methods and systems for distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) and celiac disease. The methods and systems can utilize the detection of anti-vinculin antibodies and anti-CdtB antibodies to distinguish IBS from IBD and celiac disease. Further described are methods for selecting a therapy to treat IBS, IBD or celiac disease.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: June 23, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Christopher Chang
  • Patent number: 10668159
    Abstract: The present invention relates to, in part, methods and compositions for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS). Particularly, modified-release formulations comprising at least one antimethanogenic statin are provided which release the antimethanogenic statin in the intestines.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: June 2, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Ruchi Mathur, Steve Kanzer, Vince Wacher
  • Publication number: 20200087711
    Abstract: The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.
    Type: Application
    Filed: November 25, 2019
    Publication date: March 19, 2020
    Applicant: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Ruchi Mathur, Christopher Chang
  • Publication number: 20200064330
    Abstract: Described herein are methods of detecting levels hydrogen sulfide (H2S) to diagnose H2S positive disease or conditions. Examples of H2S positive diseases and conditions include small intestinal bacterial overgrowth, diarrhea, fatigue, bowel urgency and abdominal pain. The H2S level can guide treatments for subjects who have high levels of H2S.
    Type: Application
    Filed: February 23, 2018
    Publication date: February 27, 2020
    Applicant: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Kapil Gupta, Ali Rezaie, Nipaporn Pichetshote
  • Publication number: 20200015792
    Abstract: An endoscopic device for use in a patient's body in disclosed. The endoscopic device may include an outer sheath having a proximal end and a distal end, a suction tube inside the outer sheath, a handle coupled to the distal end of the outer sheath, and a cap on the proximal end of the outer sheath, positioned to seal the proximal end of the outer sheath, wherein the outer sheath comprises a sterile appliance, wherein the cap is structured to open in response to a force applied through the suction tube, and wherein the suction tube comprises an internal cavity.
    Type: Application
    Filed: February 22, 2018
    Publication date: January 16, 2020
    Applicant: Cedars-Sinai Medical Center
    Inventors: Ali REZAIE, Mark PIMENTEL, Srinivas GADDAM, Simon LO, Laith JAMIL, Kapil GUPTA
  • Patent number: 10527621
    Abstract: The present invention describes methods for preventing IBS, reducing the likelihood of developing IBS and/or treating IBS by administering CDT inhibitors and/or CDT neutralizers to a subject in need thereof. The present invention also describes methods of eliciting a specific immune response and methods of vaccinating a subject to prevent IBS or to reduce the likelihood of developing or having IBS. The present invention further describes methods of diagnosing IBS by detecting the presence or absence of CDT or a CDT marker in a subject.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: January 7, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Christopher Chang
  • Patent number: 10519515
    Abstract: The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: December 31, 2019
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Ruchi Mathur, Christopher Chang
  • Patent number: 10466254
    Abstract: Described herein are methods and systems for the detection of anti-vinculin antibodies, for determining a presence or likely presence of a gastrointestinal motility disorder, bladder motility disorder, or fibromyalgia. Further provided are methods of selecting and/or administering a therapy based on the presence or absence of anti-vinculin antibodies.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: November 5, 2019
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Christopher Chang
  • Patent number: D874094
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: February 4, 2020
    Assignee: NIKE, Inc.
    Inventors: Maureen Carey, Mark Pimentel, Ryan Tharp
  • Patent number: D885014
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: May 26, 2020
    Assignee: NIKE, Inc.
    Inventors: Maureen Carey, Mark Pimentel, Ryan Tharp