Patents by Inventor Mark Pimentel

Mark Pimentel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250235433
    Abstract: Described herein are methods of treating and detecting nonalcoholic fatty liver disease (NAFLD) including nonalcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH).
    Type: Application
    Filed: April 18, 2023
    Publication date: July 24, 2025
    Applicants: CEDARS-SINAI MEDICAL CENTER, NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS
    Inventors: Konstantinos Triantafyllou, Mark Pimentel, Ruchi Mathur, Ali Rezaie, Gabriela Guimaraes Sousa Leite
  • Publication number: 20250197916
    Abstract: The present invention provides for methods of treating biogenic amine related conditions. Further provided are methods of detecting biogenic amine related conditions, and selection of treatment for patients in need thereof.
    Type: Application
    Filed: March 20, 2023
    Publication date: June 19, 2025
    Applicant: Cedars-Sinai Medical Center
    Inventors: Ali Rezaie, Mark Pimentel, Gabriela Leite, Janice Oh, Yin Chan
  • Publication number: 20250186513
    Abstract: The invention provides for methods of detecting and improving microbial diversity in a subject's gastrointestinal system.
    Type: Application
    Filed: April 18, 2023
    Publication date: June 12, 2025
    Applicant: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Gabriela Leite, Ruchi Mathur, Ali Rezaie, Maria Villanueva
  • Patent number: 12318186
    Abstract: Systems and methods have been developed for implementation of a breath testing system for convenient sampling of intestinal gases exhaled from a patient's breath. This may include a system with a manifold that includes thermal regulation components, for instance thermistors and resistive heating elements, which maintain the temperature of the gases above the body temperature of the patient. In some examples, the system will determine an indication of whether a patient has SIBO by adjusting a change in exhaled hydrogen concentration by a methane level exhaled by a patient.
    Type: Grant
    Filed: December 16, 2020
    Date of Patent: June 3, 2025
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Kapil Gupta, Ali Rezaie, Nicholas David Allan, Kristofor Dyck Dolberg, Nigel Anthony Syrotuck, Martin Juergen Kellinghusen, Mark Sasha Drlik, Nathan John Muller, Kenneth MacCallum
  • Patent number: 12222352
    Abstract: Described herein are methods of diagnosing systemic sclerosis (SSc) involving the detection of anti-vinculin antibodies. Also described herein are methods of selecting treatment of subjects diagnosed with systemic sclerosis (SSc), and methods of treating systemic sclerosis (SSc).
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: February 11, 2025
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Daniel Furst
  • Publication number: 20240389885
    Abstract: Described herein are methods of utilizing single fasting methane breath concentrations to monitor, select treatment for, and to treat subjects having intestinal methanogen overgrowth.
    Type: Application
    Filed: October 17, 2022
    Publication date: November 28, 2024
    Applicant: Cedars-Sinai Medical Center
    Inventors: Ali Rezaie, Mark Pimentel
  • Publication number: 20240366960
    Abstract: A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separated by a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space. In some examples, the UV light source is configured to emit light with wavelengths with significant intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.
    Type: Application
    Filed: April 19, 2024
    Publication date: November 7, 2024
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Ali Rezaie, Mark Pimentel, Gil Y. Melmed, Ruchi Mathur, Gabriela Guimaraes Sousa Leite
  • Patent number: 12071673
    Abstract: The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: August 27, 2024
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Ruchi Mathur, Christopher Chang
  • Publication number: 20240198131
    Abstract: Mitochondrial antiviral signaling (MA VS) protein mediates innate antiviral responses, and is an important component of the response to severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). Herein methods are provided to increase expression of mitochondrial antiviral signaling (MAVS) protein in epithelial cells by use of a UVA therapy to expose the epithelial cells to the UVA therapy, or to contact a first set of epithelial cells with a second set of epithelial cells which have been exposed to the UVA therapy, or to contact a first set of epithelial cells with the cell lysates of the second set of epithelial cells that have been exposed to the UVA therapy.
    Type: Application
    Filed: May 5, 2022
    Publication date: June 20, 2024
    Applicant: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Ali Rezaie, Gabriela Guimaraes Sousa Leite, Ruchi Mathur, Gil Y. Melmed
  • Patent number: 11992699
    Abstract: A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separated by a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space. In some examples, the UV light source is configured to emit light with wavelengths with significant intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.
    Type: Grant
    Filed: March 14, 2022
    Date of Patent: May 28, 2024
    Assignee: Cedars-Sinai Medical Center
    Inventors: Ali Rezaie, Mark Pimentel, Gil Y. Melmed, Ruchi Mathur, Gabriela Guimaraes Sousa Leite
  • Publication number: 20240159772
    Abstract: Described herein are methods and systems for detecting and/or distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) and celiac disease. The methods and systems can utilize the detection of anti-CdtB antibodies and/or anti-vinculin antibodies to detect IBS, distinguish IBS from IBD and/or celiac disease. Further described are methods for selecting a therapy to treat IBS, IBD or celiac disease.
    Type: Application
    Filed: May 19, 2023
    Publication date: May 16, 2024
    Applicant: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Christopher Chang
  • Publication number: 20240041306
    Abstract: An endoscopic device for use in a patient's body in disclosed. The endoscopic device may include an outer sheath having a proximal end and a distal end, a suction tube inside the outer sheath, a handle coupled to the distal end of the outer sheath, and a cap on the proximal end of the outer sheath, positioned to seal the proximal end of the outer sheath, wherein the outer sheath comprises a sterile appliance, wherein the cap is structured to open in response to a force applied through the suction tube, and wherein the suction tube comprises an internal cavity.
    Type: Application
    Filed: August 21, 2023
    Publication date: February 8, 2024
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Ali Rezaie, Mark Pimentel, Srinivas Gaddam, Simon Lo, Laith Jamil, Kapil Gupta
  • Publication number: 20240024697
    Abstract: The disclosed technology relates to a system for delivering UV-A/B light with a catheter to treat infectious or inflammatory disorders in a patient. While UV light in the UV-C range has traditionally been used to treat skin disorders and for focused ablation of plaques in the arteries and other targeted internal uses, it has not been developed for broader infection, inflammation or neoplasia treatment inside the human body. Here, the inventor(s) developed a system for emission of therapeutic doses of UV light via a catheter, capsule, endoscope, tube or port that can be used to manage internal infections and inflammatory conditions inside a patient.
    Type: Application
    Filed: August 2, 2023
    Publication date: January 25, 2024
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Ali Rezaie, Mark Pimentel, Gil Y. Melmed
  • Publication number: 20230398093
    Abstract: The present invention relates to, in part, methods for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS) using at least one anti-methanogenic lovastatin analog or derivative. In addition, modified-release formulations comprising at least one anti-methanogenic lovastatin analog or derivative are provided which release the anti-methanogenic lovastatin analog or derivative in the gastrointestinal tract.
    Type: Application
    Filed: February 6, 2023
    Publication date: December 14, 2023
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Mark Pimentel, Vince Wacher
  • Publication number: 20230302292
    Abstract: Methods and systems one or more for performing intra-luminal ultraviolet therapy for treating and/or ameliorating a gastrointestinal tract inflammation and/or infection are provided. In one example, a light delivery catheter may include a light emitting portion and non-illuminating portion, wherein the light emitting portion may include one or more UV transparent balloons. In some examples, the UV light source is configured to emit narrow-band light having wavelengths in a range between 335 nm and 349 nm.
    Type: Application
    Filed: August 13, 2021
    Publication date: September 28, 2023
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Ali Rezaie, Mark Pimentel, Gil Y. Melmed
  • Patent number: 11693009
    Abstract: Described herein are methods and systems for detecting and/or distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) and celiac disease. The methods and systems can utilize the detection of anti-CdtB antibodies and/or anti-vinculin antibodies to detect IBS, distinguish IBS from IBD and/or celiac disease. Further described are methods for selecting a therapy to treat IBS, IBD or celiac disease.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: July 4, 2023
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Christopher Chang
  • Publication number: 20230147752
    Abstract: A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separating a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space and a cooling tube. In some examples, the UV light source is configured to emit light with wavelengths with a desired intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.
    Type: Application
    Filed: March 19, 2021
    Publication date: May 11, 2023
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Ali Rezaie, Mark Pimentel, Gil Y. Melmed, Ruchi Mathur, Gabriela Guimaraes Sousa Leite, Konstantin Degtyarev, Larry Bischoff, Kuldeep Gandhi, Michael V. Quinn, Richard Cronenberg
  • Patent number: 11590102
    Abstract: The present invention relates to, in part, methods for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS) using at least one anti-methanogenic lovastatin analog or derivative. In addition, modified-release formulations comprising at least one anti-methanogenic lovastatin analog or derivative are provided which release the anti-methanogenic lovastatin analog or derivative in the gastrointestinal tract.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: February 28, 2023
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Vince Wacher
  • Publication number: 20230038019
    Abstract: Described herein are compositions and methods of treating gastrointestinal diseases and disorders such as irritable bowel syndrome and small intestinal bacterial overgrowth.
    Type: Application
    Filed: March 18, 2020
    Publication date: February 9, 2023
    Inventors: Mark PIMENTEL, Gabriela Guimaraes Sousa LEITE, Ruchi MATHUR, Ali REZAIE, Walter MORALES, Stacy WEITSMAN
  • Publication number: 20230035292
    Abstract: A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separated by a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space. In some examples, the UV light source is configured to emit light with wavelengths with significant intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.
    Type: Application
    Filed: March 14, 2022
    Publication date: February 2, 2023
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Ali Rezaie, Mark Pimentel, Gil Y. Melmed, Ruchi Mathur, Gabriela Guimaraes Sousa Leite