Patents by Inventor Mark Pimley
Mark Pimley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220133741Abstract: The present invention provides for novel combinations comprising an antihistamine with selected pharmaceutical and nutraceutical agents which alleviate some of the symptoms experienced by menopausal women, optionally combined further with a range of indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin. These mixtures may be enriched further with pharmaceutically acceptable calcium and magnesium salts as well as selected B vitamins. These combinations have utility in providing a medicament for improving health in mammals, especially for the improvement of menopausal symptoms as well as sleep in women.Type: ApplicationFiled: January 17, 2022Publication date: May 5, 2022Applicant: Requis PharmaceuticalsInventors: Lars Jacob Stray Knutsen, Judith Lois Knutsen, Mark A. Pimley
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Patent number: 11224603Abstract: The present invention provides for novel combinations comprising an antihistamine with selected pharmaceutical and nutraceutical agents which alleviate some of the symptoms experienced by menopausal women, optionally combined further with a range of indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin. These mixtures may be enriched further with pharmaceutically acceptable calcium and magnesium salts as well as selected B vitamins. These combinations have utility in providing a medicament for improving health in mammals, especially for the improvement of menopausal symptoms as welt as sleep in women.Type: GrantFiled: December 13, 2014Date of Patent: January 18, 2022Assignee: REQUIS PHARMACEUTICALS, INC.Inventors: Lars Jacob Stray Knutsen, Judith Lois Knutsen, Mark A. Pimley
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Publication number: 20160317554Abstract: The present invention provides for novel combinations comprising an antihistamine with selected pharmaceutical and nutraceutical agents which alleviate some of the symptoms experienced by menopausal women, optionally combined further with a range of indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin. These mixtures may be enriched further with pharmaceutically acceptable calcium and magnesium salts as well as selected B vitamins. These combinations have utility in providing a medicament for improving health in mammals, especially for the improvement of menopausal symptoms as welt as sleep in women.Type: ApplicationFiled: December 13, 2014Publication date: November 3, 2016Applicant: Requis Pharmaceuticals, Inc.Inventors: Lars Jacob Stray Knutsen, Judith Lois Knutsen, Mark A. Pimley
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Patent number: 9382191Abstract: A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.Type: GrantFiled: January 13, 2014Date of Patent: July 5, 2016Assignee: Actelion Pharmaceuticals, LTD.Inventors: Robert Alonso, Peter A. Crooks, Mark A. Pimley
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Publication number: 20140194526Abstract: A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.Type: ApplicationFiled: January 13, 2014Publication date: July 10, 2014Applicant: ACTELION PHARMACEUTICALS LTD.Inventors: Robert ALONSO, Peter A. CROOKS, Mark A. PIMLEY
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Publication number: 20140187810Abstract: Provided are stable compositions comprising alkylating agents, including nitrogen mustards, that are suitable for topical use, and methods for treating skin disorders comprising topically administering the compositions.Type: ApplicationFiled: June 28, 2013Publication date: July 3, 2014Applicant: Actelion Pharmaceuticals, Ltd.Inventors: Robert ALONSO, Martin STOGNIEW, Peter A. CROOKS, Mark A. PIMLEY, David R. WORTHEN
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Publication number: 20140155491Abstract: A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.Type: ApplicationFiled: June 6, 2013Publication date: June 5, 2014Inventors: Robert Alonso, Peter A. Crooks, Mark A. Pimley
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Patent number: 8664278Abstract: A composition for treating psoriasis, mycosis fungoides or alopecia comprising bis-(2-chloroethyl)methylamine or an HX salt and the pharmaceutically acceptable excipient HOCH2CH2OCH2CH2OR79, wherein R79 is a linear alkyl group having 1-6 carbon atoms.Type: GrantFiled: January 7, 2013Date of Patent: March 4, 2014Assignee: Actelion Pharmaceuticals, Ltd.Inventors: Robert Alonso, Peter A. Crooks, Mark A. Pimley
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Patent number: 8501818Abstract: Provided are stable compositions comprising alkylating agents, including nitrogen mustards, that are suitable for topical use, and methods for treating skin disorders comprising topically administering the compositions.Type: GrantFiled: January 14, 2010Date of Patent: August 6, 2013Assignee: Ceptaris Therapeutics, Inc.Inventors: Robert Alonso, Martin Stogniew, Peter A. Crooks, Mark A. Pimley, David R. Worthen
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Patent number: 8501819Abstract: A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol.Type: GrantFiled: November 17, 2010Date of Patent: August 6, 2013Assignee: Ceptaris Therapeutics, Inc.Inventors: Robert Alonso, Peter A. Crooks, Mark A. Pimley
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Patent number: 8450375Abstract: A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.Type: GrantFiled: March 14, 2006Date of Patent: May 28, 2013Assignee: Ceptaris Therapeutics, Inc.Inventors: Robert Alonso, Peter A. Crooks, Mark A. Pimley, Abeer M. Al-Ghananeem
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Publication number: 20110065803Abstract: A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.Type: ApplicationFiled: November 17, 2010Publication date: March 17, 2011Inventors: Robert Alonso, Peter A. Crooks, Mark A. Pimley
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Patent number: 7872050Abstract: A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.Type: GrantFiled: March 7, 2006Date of Patent: January 18, 2011Assignee: Yaupon Therapeutics Inc.Inventors: Robert Alonso, Peter A. Crooks, Mark A. Pimley
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Patent number: 7838564Abstract: A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.Type: GrantFiled: August 27, 2009Date of Patent: November 23, 2010Assignee: Yaupon Therapeutics Inc.Inventors: Robert Alonso, Peter A. Crooks, Mark A. Pimley, Abeer M. Al-Ghananeem
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Publication number: 20100152300Abstract: Provided are stable compositions comprising alkylating agents, including nitrogen mustards, that are suitable for topical use, and methods for treating skin disorders comprising topically administering the compositions.Type: ApplicationFiled: January 14, 2010Publication date: June 17, 2010Inventors: Robert ALONSO, Martin Stogniew, Peter A. Crooks, Mark A. Pimley, Stuart R. Lessin, David R. Worthen
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Publication number: 20100041767Abstract: A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.Type: ApplicationFiled: August 27, 2009Publication date: February 18, 2010Applicant: YAUPON THERAPEUTICS, INC.Inventors: Robert Alonso, Peter A. Crooks, Mark A. Pimley, Stuart R. Lessin, Abeer M. Al-Ghananeem
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Publication number: 20080194699Abstract: A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.Type: ApplicationFiled: March 14, 2006Publication date: August 14, 2008Inventors: Robert Alonso, Peter A. Crooks, Mark A. Pimley, Stuart R. Lessin, Abeer M. Al-Ghananeem
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Publication number: 20060205694Abstract: A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.Type: ApplicationFiled: March 7, 2006Publication date: September 14, 2006Inventors: Robert Alonso, Peter Crooks, Mark Pimley, Stuart Lessin